A5067390361- Bioactive Compounds and Antitumor Agents
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Medicinal Plants and Neuroprotection
- Drug Transport and Resistance Mechanisms
- Nephrotoxicity and Medicinal Plants
- Antibiotics Pharmacokinetics and Efficacy
- Drug-Induced Hepatotoxicity and Protection
- RNA modifications and cancer
- Bioactive natural compounds
- Plant tissue culture and regeneration
- Cancer Treatment and Pharmacology
- Photodynamic Therapy Research Studies
- Phytochemistry and Biological Activities
- Genomics, phytochemicals, and oxidative stress
- Transgenic Plants and Applications
- Allelopathy and phytotoxic interactions
- Essential Oils and Antimicrobial Activity
- Nigella sativa pharmacological applications
- Aluminum toxicity and tolerance in plants and animals
- Synthesis of Organic Compounds
- Chemotherapy-induced organ toxicity mitigation
- Ginger and Zingiberaceae research
- Chemotherapy-induced cardiotoxicity and mitigation
- Moringa oleifera research and applications
Al Baha University
2022-2024
Bangor University
2022
Gastric ulcer (GU) is a lesion in the gastric mucosa associated with excessive oxidative damage, inflammatory response, apoptotic events, and irritation which may develop into cancer. However, medications commonly used GU treatment cannot normalize mucosa, while causing several adverse effects. Proanthocyanidins (PAs) are dietary flavonoids numerous biological pharmacological activities. In current investigation, we studied potential anti-ulcerative activity of PAs against acidified ethanol...
The combretastatins (cis-stilbenoid molecules) have received significant interest because of their simple chemical structures, excellent antiproliferative activity, and novel anti-tubulin molecular mechanism action. Significant efforts been carried out aiming at stabilizing the active cis-isomers. A new series cis-vinylamide derivatives containing trimethoxyphenyl moiety were synthesized characterized. Their anticancer activities evaluated in vitro against MCF-7 breast cancer cell line....
Prodigiosin (PDG) is a bacterial metabolite with numerous biological and pharmaceutical properties. Exposure to aluminium considered root etiological factor in the pathological progress of Alzheimer's disease (AD). Here, this investigation, we explored neuroprotective potential PDG against chloride (AlCl3 )-mediated AD-like neurological alterations rats. For purpose, rats were gavaged either AlCl3 (100 mg/kg), (300 or both for 42 days. As result analyzes performed on hippocampal tissue, it...
Few researches have explored the production of pharmaceuticals from aquatic plants. Therefore, this study explored, for first time, phytochemical composition and bioactivities ten Aquatic plant shoots various Nile River canals were collected, dried, ground aqueous extract preparation. Phytochemical antioxidant capacity assessed using DPPH assays. Extracts tested antiparasitic, antibacterial, anti-biofilm, anticancer activities through standard in vitro assays, measuring IC50 values,...
Abstract Asiatic acid (AA) is a polyphenolic compound with potent antioxidative and anti-inflammatory activities that make it potential choice to attenuate inflammation oxidative insults associated ulcerative colitis (UC). Hence, the present study aimed evaluate if AA can molecular, biochemical, histological alterations in acetic acid-induced UC model rats. To perform study, five groups were applied, including control, UC, UC-treated 40 mg/kg aminosalicylate (5-ASA), 20 AA, AA. Levels of...
Globally, colorectal cancer (CRC) is categorized as the third type of associated with mortalities. Chemotherapeutic drugs such cisplatin can be used to treat cancer-affected patients. However, several adverse effects are its application. This motivated researchers search for alternatives that more efficient and have fewer undesirable effects. Kolaviron a bioflavonoid has been reported antioxidant anti-inflammatory properties.
The conserved nucleic acid binding protein Translin contributes to numerous facets of mammalian biology and genetic diseases. It was first identified as a binder cancer-associated chromosomal translocation breakpoint junctions leading the suggestion that it involved in recombination. With paralogous partner protein, Trax, has subsequently been found form hetero-octomeric RNase complex drives some its functions, including passenger strand removal RNA interference (RNAi). Translin-Trax also...
Abstract Gentamicin (GM) is an aminoglycoside antibiotic used to treat bacterial infections. However, its application accompanied by renal impairments. Apigenin a flavonoid found in many edible plants with potent therapeutic values. This study was designed elucidate the effects of apigenin on GM-induced nephrotoxicity. Animals were injected orally three different doses (5, 10 and 20 mg kg -1 day ). administration abolished alterations kidney index serum levels kidney-specific functions...