A5030185245- Circadian rhythm and melatonin
- Spaceflight effects on biology
- Photoreceptor and optogenetics research
- Medicinal Plants and Neuroprotection
- Parasites and Host Interactions
- Cystic Fibrosis Research Advances
- Birth, Development, and Health
- Psoriasis: Treatment and Pathogenesis
- Vibrio bacteria research studies
- Light effects on plants
- Sleep and Wakefulness Research
- Coenzyme Q10 studies and effects
- Advanced battery technologies research
- Ginger and Zingiberaceae research
- Aluminum toxicity and tolerance in plants and animals
- Autoimmune and Inflammatory Disorders Research
- Nigella sativa pharmacological applications
- Cytokine Signaling Pathways and Interactions
- Anesthesia and Neurotoxicity Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Dermatology and Skin Diseases
- Tryptophan and brain disorders
- Heavy Metal Exposure and Toxicity
- Whipple's Disease and Interleukins
- Dietary Effects on Health
Helwan University
2016-2024
Czech Academy of Sciences
2006-2009
Czech Academy of Sciences, Institute of Physiology
2008-2009
Arsenic is a neurotoxic substance that makes the brain susceptible to free radicals. Thymoquinone (TQ) potent antioxidant extracted from Nigella sativa seeds. It scavenges radicals and prevents cell damage resulted oxidative substances. In this study, ameliorative effect of TQ in arsenic-induced neurotoxicity was investigated. Rats were treated for 21 days with: distilled water, 20 mg/kg sodium arsenate, 10 TQ, arsenate followed by TQ. Cerebral cortex, cerebellum stem removed measurements...
Exposure to lead (Pb) causes multiorgan dysfunction including reproductive impairments. Here, we examined the protective effects of coenzyme Q10 (CoQ10) administration on testicular injury induced by acetate (PbAc) exposure in rats. This study employed four experimental groups (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>7</mml:mn></mml:math>) that underwent seven days treatment as follows: control group intraperitoneally...
Abstract The molecular mechanism underlying circadian rhythmicity within the suprachiasmatic nuclei (SCN) of hypothalamus has two light‐sensitive components, namely clock genes Per1 and Per2 . Besides, light induces immediate‐early gene c‐fos In adult rats, expression all three is induced by administered during subjective night but not day. aim present study was to ascertain when where SCN photic sensitivity , develops early postnatal ontogenesis. specific find out starts gate sensitivity....
The molecular clockwork underlying the generation of circadian rhythmicity within suprachiasmatic nucleus (SCN) develops gradually during ontogenesis. authors' previous work has shown that rhythms in clock gene expression rat SCN are not detectable at embryonic day (E) 19, start to form E20 and develop further via increasing amplitude until postnatal (P) 10. aim present was elucidate whether how swiftly immature fetal neonatal clocks can be reset by maternal cues. Pregnant rats maintained...
Prodigiosin (PDG) is a bacterial metabolite with numerous biological and pharmaceutical properties. Exposure to aluminium considered root etiological factor in the pathological progress of Alzheimer's disease (AD). Here, this investigation, we explored neuroprotective potential PDG against chloride (AlCl3 )-mediated AD-like neurological alterations rats. For purpose, rats were gavaged either AlCl3 (100 mg/kg), (300 or both for 42 days. As result analyzes performed on hippocampal tissue, it...
Respiratory infections by bacteria of the Burkholderia cepacia complex (Bcc) remain an important cause morbidity and mortality among cystic fibrosis patients, highlighting need for novel therapeutic strategies. In present work we have studied B. cenocepacia protein BCAL2958, a member OmpA-like family proteins, demonstrated as highly immunogenic in other pathogens capable eliciting strong host immune responses. The encoding gene was cloned protein, produced 6× His-tagged derivative, used to...
The aging process is characterized by circadian rhythm disruption, in physiology and behavior, which could result from weak entrainment. Light the most potent cue that entrains central clock, turn synchronizes peripheral clocks animal tissues. Period 2
The mammalian circadian pacemaker is located in the suprachiasmatic nucleus (SCN), which composed of dorsomedial (dm) and ventrolateral (vl) regions. molecular clockwork responsible for SCN rhythmicity consists clock genes their transcriptional‐translational feedback loops. rat are affected by photoperiod. aim this study was to elucidate development rhythmicity, namely dm‐ vl‐SCN expression ascertain when photoperiod starts affect rhythmicity. Rhythmicity dm‐SCN, measured as rhythm...
Response to treatment usually depends on the time of drug administration. Interleukin-22 (IL-22) is known for its protective effect against liver injury. Therefore, aim was study effectiveness IL-22 at different circadian timing S. mansoni-infected mice. Mice grouping included; control group, mice infected with cercariae, and IL-22-treated groups. Treatment (0.36 µg/kg) performed either 7 am, or pm. Hepatic granuloma index (GI), levels tumor necrosis factor-α (TNF-α), interleukin-17 (IL-17),...
Background/Aim: Praziquantel (PZQ), the primary medication for schistosomiasis treatment, exhibits a potential resistance by parasite. Therefore, development of new effective treatment is obligated. Interleukin-22 (IL-22) has been reported to have hepatoprotective effect. The current study aimed compare effectiveness IL-22 versus PZQ against S. mansoni - induced liver fibrosis in mice. Materials and Methods: Forty male albino mice were divided into control, infected, (0.36 µg/kg), (a single...
Abstract Asiatic acid (AA) is a polyphenolic compound with potent antioxidative and anti-inflammatory activities that make it potential choice to attenuate inflammation oxidative insults associated ulcerative colitis (UC). Hence, the present study aimed evaluate if AA can molecular, biochemical, histological alterations in acetic acid-induced UC model rats. To perform study, five groups were applied, including control, UC, UC-treated 40 mg/kg aminosalicylate (5-ASA), 20 AA, AA. Levels of...
Back ground: Many animals use the length of day (photoperiod) to predict and adjust seasonal changes in environment through predictive physiology behaviour. The present work is designed study effect different photoperiod regimes, i.e., short 10L:14D, long 14L:10D 12L:12D light-dark cycle (LD) on structure hormonal secretion thyroid gland ovaries adult aged female rats. Material methods: rats were divided into 6 groups, each group contained adults (6 months old) or (18 maintained for one...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Nady S, Abdel-Rahman M, Sousa SA, Leitão JH, Morad El-Hennamy RE. Differential effects of Th17 cytokines during the response neutrophils to Burkholderia cenocepacia outer membrane protein A. Central European Journal Immunology. 2019;44(4):403-413. doi:10.5114/ceji.2019.92800. APA Nady, S., Abdel-Rahman, M., Sousa, Leitão, J., Morad, & El-Hennamy, R. (2019). Immunology, 44(4), 403-413....
Decreased light input to the suprachiasmatic nuclei (SCN) is believed cause alterations of circadian rhythm. Alzheimer disease (AD) commonly associated with disturbances in behavior and sleep patterns which caused by rhythm abnormalities. The present study aimed investigate role exposure during night re-entrainment aged rats. Besides, examining possibility using pulse late decrease risk disease. Levels melatonin, acetylcholine (ACh), serotonin (5-HT), norepinephrine (NE) were measured four...
The present study aimed to compare the immune-enhancing potential of gold nanoparticles (AuNPs) Alum against rabies vaccine and related immunological, physiological, histopathological effects.Alum AuNPs sole in combination with were used at 0.35 mg/mL 40 nM/mL, respectively. Rats categorized into six groups (20/each): control rats, vaccine, aluminum phosphate gel, adsorbed Alum, AuNPs, adjuvant AuNPs.Liver kidney functions normal range after adjuvanted compared control. Interleukin-6...