A5088890037- Rabies epidemiology and control
- Immune Response and Inflammation
- Nanoparticles: synthesis and applications
- Microbial Natural Products and Biosynthesis
- Immune responses and vaccinations
- Dietary Effects on Health
- Viral Infections and Outbreaks Research
- Neurological Disorders and Treatments
- Computational Drug Discovery Methods
- Curcumin's Biomedical Applications
- Bee Products Chemical Analysis
- Viral Infectious Diseases and Gene Expression in Insects
- Mosquito-borne diseases and control
- Cancer Research and Treatments
- Microbial Metabolism and Applications
- Natural product bioactivities and synthesis
- Nanoparticle-Based Drug Delivery
- Natural Compound Pharmacology Studies
- Seaweed-derived Bioactive Compounds
- Neurogenesis and neuroplasticity mechanisms
- SARS-CoV-2 and COVID-19 Research
- Cancer Research and Treatment
- Cell death mechanisms and regulation
- Circular RNAs in diseases
- Nanoplatforms for cancer theranostics
Al-Azhar University
2019-2023
Damietta University
2020-2023
Zinc oxide nanomaterial is a potential material in the field of cancer therapy. In this study, zinc nanospheres (ZnO-NS) were synthesized by Sol-gel method using yeast extract as non-toxic bio-template and investigated their physicochemical properties through various techniques such FTIR, XR, DLS, TEM. Furthermore, free ions released from nanosphere suspended medium evaluated ICP-AS technique. Therefore, cytotoxicity ZnO Zn on both HuH7 Vero cells was studied MTT assay. The data demonstrated...
Resistance to antibiotics and anticancer therapy is a serious global health threat particularly in immunosuppressed cancer patients. Current study aimed estimate the antibacterial potentials of short-term exposure extremely low frequency electromagnetic field (ELF-EMF) silver nanoparticles (AgNPs) either sole or combined form.Antibacterial activity was evaluated via determination bacterial viable count reduction percentage following exposure, whereas their ability induce apoptosis breast...
Burn injuries are underappreciated that cause significant morbidity and mortality. injuries, especially severe burns, trigger immunological inflammatory responses, metabolic abnormalities, distributive shock, all of which can be extended to multiple organ failures. Aloe vera (A. vera) has been exploited for its medicinal properties centuries. The goal the present study is examine therapeutic effect topical oral administration A. against deep second-degree burn in rats.skin was created on...
Abstract Cancer is known to be a fierce disease that causes large percentage of the deaths worldwide. The common cancer treatments; chemotherapy, radiotherapy and surgery are for their severe side effects; therefore scientists working on finding solutions reduce these drawbacks. One treatment systems sustained released drugs formulations, depend encapsulation chemotherapy within an emulsifying agent, in order obtain slow drug release low doses over long time intervals. In this study,...
One of the essential goals regarding successful control rabies infection is development a safe, effective, and inexpensive vaccine. current study aimed to evaluate inactivation potential β-propiolactone (βPL), binary ethyleneimine (BEI), hydrogen peroxide (H2O2).Estimating kinetics βPL, BEI, H2O2 revealed that tested inactivants could completely irreversibly inactivate virus within 2, 12, 4 hours, respectively while maintaining its viral immunogenicity. The potency inactivated vaccines was...
The present work aimed to evaluate the reactivity of natural bioflavonoid hesperidin (HSP) and synthetically derived XAV939 (XAV) against human hepatocellular carcinoma (HepG2), breast cancer (MDA-MB231) cell lines, related molecular pathological profiles. Data recorded revealed that cytotoxic potential tested products was found be type- concentration-dependent. half-maximal inhibitory concentration (IC50) value HSP-XAV mixture MDA-MB231 significantly decreased in case using HepG2 line....
The extremely-low frequency electromagnetic field (ELFEMF) has been proposed for use in cancer therapy since it was found that magnetic waves interfere with many biological processes. Gold nanoparticles (Au-NPs) have widely used drug delivery during vitro studies due to their low cytotoxity and high biocompatibility. electroporation of cells a presence Au-NPs (EP Au-NPs) can induce cell apoptosis, alterations cycle profile morphological changes. impact ELFEMF EP on morphology, activation...
The present work aimed to use natural derived fungal secondary metabolites as anticancer agents concerning cytotoxicity, apoptotic, genetic and histopathological profile. It was noticed that Asp. Terrius (Asp. T), Flavous Fl) Fumegatgus Fu) induced variable toxic potential cell type, metabolite type concentration dependent. CaCo-2 cells showed less sensitivity than HuH-7 in turn the IC50 variable. Also, apoptotic of species proven via detection up regulated pro genes down regulation...
The present study aimed to compare the immune-enhancing potential of gold nanoparticles (AuNPs) Alum against rabies vaccine and related immunological, physiological, histopathological effects.Alum AuNPs sole in combination with were used at 0.35 mg/mL 40 nM/mL, respectively. Rats categorized into six groups (20/each): control rats, vaccine, aluminum phosphate gel, adsorbed Alum, AuNPs, adjuvant AuNPs.Liver kidney functions normal range after adjuvanted compared control. Interleukin-6...
Background:The therapeutic efficacy of stem cell therapy in many diseased organs based greatly on their paracrine effect.The neural cells are thought to have a role improving the neurological functional, recovery, and reduction cerebral infarction caused by ischemia/ reperfusion [I/R] injury rats.Objective: This study was conducted look at histological alterations rat cortex after ischemia-reperfusion assess any potential neuroprotective effects conditioned media [NSC-CM] those...
Introduction and aim: Obesity is a worldwide epidemic nearly affects every organ. However, the renal changes in obesity are not sufficiently addressed. Thus we aimed to investigate effects of high-fat diet induced on kidney explore effect caloric restriction associated with obesity. Methodology: Thirty male albino rats, 160-180 g included divided into three equal groups. The first control group (received nothing except normal diet). second high fat diet-fed group, where rats fed for 12...
Current studyaimed to evaluate the antiviral activities of free silver nanoparticles (AgNPs) and hydrogen peroxide combined nanoparticles(AgNP-H2O2) compared standard IFN-α2a against Herpes simplex virus type-1 (HSV-1), Vesicular stomatitis (VSV) Middle East respiratory syndrome-coronavirus (MERS-CoV). The related biochemical pathological changes as well asthe expression levels biomarkers, namely Mx-A 2'-5'-oligoadenylate synthetase (2'-5'-OAS)were investigated. Cytotoxicity AgNPs AgNP-H2O2...