A5075114265- Natural Antidiabetic Agents Studies
- Liver Disease Diagnosis and Treatment
- Bee Products Chemical Analysis
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Ginger and Zingiberaceae research
- Apelin-related biomedical research
- Stress Responses and Cortisol
- Microbial Natural Products and Biosynthesis
- Nanoparticles: synthesis and applications
- Drug-Induced Hepatotoxicity and Protection
- Computational Drug Discovery Methods
- Adipose Tissue and Metabolism
- Traditional Chinese Medicine Analysis
- Viral Infections and Outbreaks Research
- Rabies epidemiology and control
- Biological Activity of Diterpenoids and Biflavonoids
- Pomegranate: compositions and health benefits
- Signaling Pathways in Disease
- Advancements in Transdermal Drug Delivery
- Pancreatic function and diabetes
- Medicinal Plants and Bioactive Compounds
- Curcumin's Biomedical Applications
- Advances in Cucurbitaceae Research
- Sperm and Testicular Function
Al-Ahliyya Amman University
2024
Al-Azhar University
2013-2024
Al-Azhar University
2015-2021
Newcastle University
2012
Al Azhar University
2012
Owing to their great quantity of hydrolyzable anthocyanins and tannins, the peel seeds pomegranate are edible possess potent anti-oxidant anti-inflammatory characteristics. This work aims trace seed ethanolic extracts' anticancer activity against liver cancer cell line, namely HepG2 related histopathological, immunohistochemical, genetic oxidative stress profile.In vitro study for both extract showed prevalence phenols, polyphenols acids, those have anti-proliferative potential line (HepG2)...
Nonalcoholic fatty liver disease (NAFLD) is a major hepatic disorder occurring in non-alcohol-drinking individuals. Salvianic acid A or
Diabetes mellitus (DM) induces the production of reactive oxygen species, which may lead to cell injury and death. This study aimed assess effects rosmarinic acid (RA) on testicular damage, oxidative stress, apoptosis in streptozotocin (STZ)-induced diabetic albino mice. DM four- six-week-old BALB/c male mice was induced via 50 mg/kg STZ, IP for 5 days. Twelve were randomly assigned into each following groups: a control group, RA5 RA15 groups, + groups. RA doses intraperitoneally injected...
Zinc oxide nanomaterial is a potential material in the field of cancer therapy. In this study, zinc nanospheres (ZnO-NS) were synthesized by Sol-gel method using yeast extract as non-toxic bio-template and investigated their physicochemical properties through various techniques such FTIR, XR, DLS, TEM. Furthermore, free ions released from nanosphere suspended medium evaluated ICP-AS technique. Therefore, cytotoxicity ZnO Zn on both HuH7 Vero cells was studied MTT assay. The data demonstrated...
Resistance to antibiotics and anticancer therapy is a serious global health threat particularly in immunosuppressed cancer patients. Current study aimed estimate the antibacterial potentials of short-term exposure extremely low frequency electromagnetic field (ELF-EMF) silver nanoparticles (AgNPs) either sole or combined form.Antibacterial activity was evaluated via determination bacterial viable count reduction percentage following exposure, whereas their ability induce apoptosis breast...
Abstract Cancer is known to be a fierce disease that causes large percentage of the deaths worldwide. The common cancer treatments; chemotherapy, radiotherapy and surgery are for their severe side effects; therefore scientists working on finding solutions reduce these drawbacks. One treatment systems sustained released drugs formulations, depend encapsulation chemotherapy within an emulsifying agent, in order obtain slow drug release low doses over long time intervals. In this study,...
Staphylococcus aureus and methicillin-resistant (MRSA) are classified as high-risk infections that can lead to death, particularly among older individuals. Nowadays, plant nanoparticles such glycyrrhizic acid recognized efficient bactericides against a wide range of bacterial strains. Recently, scientists have shown interest in extract nanoparticles, derived from natural sources, which be synthesized into nanomaterials. Interestingly, is rich antioxidants well antibacterial agents, it...
Diabetes mellitus is one of the common and widely distributed metabolic diseases all over world. This disease characterized by hyperglycemia that results from defects in insulin secretion, action or both. Different medicinal plant species are used as a traditional treatment for diabetes e.g. Ambrosia maritima, L. (Damsissa) which these plants its extract was to treat diabetic patients long times ago. Aim work: work aimed investigate antidiabetic, hypolipidemic antioxidant effects aqueous...
One of the essential goals regarding successful control rabies infection is development a safe, effective, and inexpensive vaccine. current study aimed to evaluate inactivation potential β-propiolactone (βPL), binary ethyleneimine (BEI), hydrogen peroxide (H2O2).Estimating kinetics βPL, BEI, H2O2 revealed that tested inactivants could completely irreversibly inactivate virus within 2, 12, 4 hours, respectively while maintaining its viral immunogenicity. The potency inactivated vaccines was...
The present work aimed to evaluate the reactivity of natural bioflavonoid hesperidin (HSP) and synthetically derived XAV939 (XAV) against human hepatocellular carcinoma (HepG2), breast cancer (MDA-MB231) cell lines, related molecular pathological profiles. Data recorded revealed that cytotoxic potential tested products was found be type- concentration-dependent. half-maximal inhibitory concentration (IC50) value HSP-XAV mixture MDA-MB231 significantly decreased in case using HepG2 line....
The extremely-low frequency electromagnetic field (ELFEMF) has been proposed for use in cancer therapy since it was found that magnetic waves interfere with many biological processes. Gold nanoparticles (Au-NPs) have widely used drug delivery during vitro studies due to their low cytotoxity and high biocompatibility. electroporation of cells a presence Au-NPs (EP Au-NPs) can induce cell apoptosis, alterations cycle profile morphological changes. impact ELFEMF EP on morphology, activation...
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a common affecting nearly 25% of adults worldwide with related risk factors including obesity, metabolic, and inflammatory diseases. Many therapeutic remedies natural or synthetic properties were used. AIM: This study aimed to investigate compare the effects ginger/rosuvastatin (ROSU) on rats induced NAFLD. MATERIALS AND METHODS: Forty adult male albino used in this divided into four equal subgroups, Group I, control received standard...
Background:diabetes mellitus is a metabolic disorder in the endocrine system with common biochemical manifestation, thus hyper-glycemia disturbed carbohydrate metabolism. This work aimed to evaluate role of antidiabetic and hypoglycemic drug glibenclamide as chemical agent and Aphanizomenon flos- aquae extract natural on lymphoid organs such lymph nodes spleen diabetic (type-2) white male albino rats. Material methods –Fifty rats were used categorized into five groups; group 1: control...
Diabetes mellitus is one of the common and widely distributed metabolic diseases all over world. This disease characterized by hyperglycemia that results from defects in insulin secretion, action or both. In Asia, different medicinal plant species are used as a traditional treatment for diabetes e.g. Jasonia montana (Neheda) was these plants mixture to treat diabetic patients long times ago. Aim work: work aimed investigate antidiabetic, hypolipidemic antioxidant effects aqueous extract on...
Abstract: Exposure to crowding stress is associated with increased respiratory system morbidity, However, the underlying mechanisms are unclear. Thus, there a need for more study of this harmful effect. Sulpiride had been shown have protective role against on other systems but was not studied well and cardiovascular systems. Objectives: Investigating possible effects adult albino rats' lung heart combined sulpiride treatment. Materials Methods: The present carried out 24 rats local strain...
Background: Millions of individuals worldwide are unintentionally exposed to arsenic through food and water. Arsenic bioaccumulates in the human body causes organ toxicity, especially hepatotoxicity, apoptosis, inflammation, production oxidative stress markers. Aim study: We aimed determine whether Ginger (Zingiber officinale) or omega-3 could mitigate hepatotoxicity that rats experienced from long-term exposure drinking Methods: Rats were randomly assigned into four groups (10/group): a...
Abstract Background and purpose Collagen cross-linking (CXL) has evolved as an essential therapeutic approach for corneal infections, allowing rapidly eliminating the infecting microorganism while reducing inflammation. This study aims to evaluate efficacy of CXL a monotherapy managing infectious keratitis caused by Fusarium solani Pseudomonas aeruginosa. Materials methods Forty-eight white New Zealand rabbits weighing approximately 1.5–2 KG were included. The cornea one eye each rabbit was...
Sitagliptin is highly selective dipeptidyl peptidase-4 (DPP-4) inhibitor that considered as one of the new oral therapies for management type II diabetes.Because sitagliptin unknown effects on endocrine part pancreas, especially cellular levels, this study was done to evaluate its effect pancreas in experimentally-induced diabetic adult albino rats. Material and Methods:The present carried out 30 male rats which were divided into; Group I (untreated control group), (diabetic where diabetes...
The present work aimed to use natural derived fungal secondary metabolites as anticancer agents concerning cytotoxicity, apoptotic, genetic and histopathological profile. It was noticed that Asp. Terrius (Asp. T), Flavous Fl) Fumegatgus Fu) induced variable toxic potential cell type, metabolite type concentration dependent. CaCo-2 cells showed less sensitivity than HuH-7 in turn the IC50 variable. Also, apoptotic of species proven via detection up regulated pro genes down regulation...