A5031041865- Phytochemistry and Biological Activities
- Plant biochemistry and biosynthesis
- Essential Oils and Antimicrobial Activity
- Microbial Metabolites in Food Biotechnology
- Natural product bioactivities and synthesis
- Bioactive Compounds and Antitumor Agents
- Seed and Plant Biochemistry
- Cancer Treatment and Pharmacology
- Natural Antidiabetic Agents Studies
- Photoreceptor and optogenetics research
- Medicinal Plant Research
- Pharmacological Effects of Natural Compounds
- GABA and Rice Research
- Microbial Natural Products and Biosynthesis
- Andrographolide Research and Applications
- Molecular spectroscopy and chirality
- Alkaloids: synthesis and pharmacology
- Trace Elements in Health
- Sesquiterpenes and Asteraceae Studies
- Advanced NMR Techniques and Applications
- Heavy Metal Exposure and Toxicity
- Electrochemical Analysis and Applications
- Glycosylation and Glycoproteins Research
- Bioactive natural compounds
- Bee Products Chemical Analysis
Universidad de Alcalá
2021-2025
Universidade Lusófona
2020-2025
Rede de Química e Tecnologia
2023
Universidade do Porto
2023
University of Tartu
2023
Nonalcoholic fatty liver disease (NAFLD) is a major hepatic disorder occurring in non-alcohol-drinking individuals. Salvianic acid A or
Since cancer treatment by radio- and chemotherapy has been linked to safety concerns, there is a need for new alternative anticancer drugs; as such, compounds isolated from plants represent promising candidates. The current study investigates the features of halimane (11R*,13E)-11-acetoxyhalima-5,13-dien-15-oic acid (HAL) labdane diterpenes 1α,6β-diacetoxy-8α,13R*-epoxy-14-labden-11-one (PLEC) forskolin-like 1:1 mixture 1,6-di-O-acetylforskolin 1,6-di-O-acetyl-9-deoxyforskolin (MRC)...
Vitamin C was examined to ameliorate the neurotoxicity of thimerosal (THIM) in an animal model (Wistar albino rats). In our work, oxidative and antioxidative biomarkers such as SOD, LPO, GSH were investigated at various doses THIM with or without concurrent vitamin administration. Furthermore, adverse effects on hepatic tissue cerebral cortex morphology absence presence associated Also, we studied effect metallothionein isoforms (MT-1, MT-2, MT-3) silico vivo using RT-PCR assay. The results...
The Plectranthus genus is often cited for its medicinal properties. ornatus Codd. traditionally used in Africa the treatment of gastric and liver diseases their leaves are antibiotic action. main constituent P. halimane compound, 11 R
Abstract Protein kinase C is a family of kinases that play important roles in carcinogenesis. Medicinal plants from Plectranthus spp. (Lamiaceae) are well-known source interesting abietanes, such as 7α-acetoxy-6β-hydroxyroyleanone ( Roy ). This study aimed to extract and isolate P. grandidentatus Gürke, comparing two extraction methods (CO 2 supercritical ultrasound-assisted acetonic extraction), design new royleanone derivatives for PKC modulation focusing on breast cancer therapy. The...
Honey, a natural production of honeybees, underscores Turkey's prominence as one the world's largest honey producers. The country's diverse flora fosters optimal conditions for beekeeping, resulting in exceptional-quality honey. Centauri® Honey is uniquely sourced from remote alpine regions Turkey, characterized by bees that inhabit isolated caves with access to medicinal endemic flowers year-round, promoting unique and pristine environment. This study evaluates quality, physicochemical...
Plectranthus ornatus Codd, the genus of Lamiaceae family, has been used as traditional medicine in Africa, India and Australia. Pharmacological studies show use this plant to treat digestive problems. In turn, leaves were for their antibiotic properties some regions Brazil skin infections. The present study examines anti-inflammatory, antioxidant cytotoxic effects halimane labdane diterpenes (11R*,13E)-11-acetoxyhalima-5,13-dien-15-oic acid (HAL)...
Different approaches have been reported to enhance penetration of small drugs through physiological barriers; among them is the self-assembly drug conjugates preparation that shows be a promising approach improve activity and penetration, as well reduce side effects. In recent years, use drug-conjugates, usually obtained by covalent coupling with biocompatible lipid moieties form nanoparticles, has gained considerable attention. Natural products isolated from plants successful source...
The Neocarya macrophylla plant is used traditionally for food, medicinal, spiritual and industrial purposes. It also as a soap, dye, glue, fodder, termite repellent, firewood structural materials. Few studies on the physicochemical, nutritional content, phytochemical pharmacological activities have validated benefits of N. to humanity in cosmetics or pharmaceutical products. major bioactive constituents identified so far are steroids flavonoids, such as, stigmasterol, quercetin, catechin its...
Multidrug resistance (MDR) presents a significant challenge in modern pharmacotherapy, greatly diminishing the effectiveness of chemotherapeutic agents. A primary mechanism contributing to MDR is overexpression P-glycoprotein (P-gp), also known as MDR1, encoded by ABCB1 gene, which hampers success cancer treatments. Plants from Plectranthus genus (Lamiaceae) have been traditionally acknowledged for their diverse therapeutic applications. The principal diterpene grandidentatus Gürke,...
<title>Abstract</title> Protein kinase C is a family of kinases that play important roles in carcinogenesis . Medicinal plants from <italic>Plectranthus spp.</italic> (Lamiaceae) are well-known source interesting abietanes, such as the 7α-acetoxy-6β-hydroxyroyleanone (<bold>Roy</bold>). The aim this study was to extract and isolate <bold>Roy</bold> <italic>P. grandidentatus</italic> Gürke compare two extraction methods (the CO<sub>2</sub> supercritical ultrasound-assisted acetonic...
The Plectranthus genus belongs to the Lamiaceae family and consists of around 300 species distributed from Africa Asia Australia. spp. has been reported be rich in diterpenoids, such as different types royleanones. One medicinal plant is P. hadiensis (Forssk.) Schweinf. ex Sprenger, which contains diverse metabolites phenolic diterpenoid compounds. Furthermore, this widely used an array traditional Ayurveda recipes for treatment range ailments like cancer. Therefore, aim work was isolate...
With an estimated 28,137 recorded medicinal plants species, it is not surprising that over 80% of the world's population rely on traditional herbal medicines as their primary source healthcare. In recent years, use in West has seen a resurgence, alternative and complementary approach to treating preventing disease. Plectranthus species (Lamiaceae family) have widespread ethnobotanical uses, including southern Africa treat listeriosis, tuberculosis-related problems skin diseases. The...
The number of multidrug resistant (MDR) cancer cases across the globe is continuing to rise, such that search for novel anti-cancer therapeutics paramount. For instance, overexpression membrane transport proteins, as P-glycoprotein (P-gp), or selective modulation protein kinases C (PKC) isoforms continues be a major impediment effective therapy. Known their medicinal properties, species from Plectranthus have been reported cytotoxicity against various cell lines due diterpenes,...
Natural products are an important source of lead compounds for drug discovery. Plectranthus (Lamiaceae family) is Old-World genus widely used in traditional medicine, whose species rich pharmacologically active compounds, specifically diterpenes. Two molecules reported spp. the diterpenoids 7α-acetoxy-6β-hydroxyroyleanone (Roy, [Fig. 1]) and 6,7-dehydroroyleanone (DeRoy, [1]. Previous studies vitro activity Roy DeRoy against several breast cancer cell lines [1], [2]. Furthermore, silico...
Multidrug resistance (MDR) is one of the major obstacles in cancer chemotherapy. MDR often associated with overexpression efflux pump, P-glycoprotein (P-gp). The growing incidence and development drive search for novel more effective anticancer drugs. In this context, we have recognized Plectranthus plants as potential sources lead compounds. Accordingly, two natural diterpenoids, 6,7-dehydroroyleanone (1) 7α-acetoxy-6β-hydroxyroyleanone (2) obtained from spp., exhibited promising cytotoxic...