A5066651403- DNA Repair Mechanisms
- Tryptophan and brain disorders
- PARP inhibition in cancer therapy
- Stress Responses and Cortisol
- Plant tissue culture and regeneration
- Essential Oils and Antimicrobial Activity
- DNA and Nucleic Acid Chemistry
- Toxin Mechanisms and Immunotoxins
- Carcinogens and Genotoxicity Assessment
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Transgenic Plants and Applications
- Genomics, phytochemicals, and oxidative stress
- Cancer therapeutics and mechanisms
- Plant biochemistry and biosynthesis
- CRISPR and Genetic Engineering
- Genetics and Neurodevelopmental Disorders
- Acute Lymphoblastic Leukemia research
- Genetic factors in colorectal cancer
- Bioactive Compounds and Antitumor Agents
- Bee Products Chemical Analysis
- Chronic Myeloid Leukemia Treatments
- Cancer-related Molecular Pathways
University of Łódź
2015-2024
Medical University of Lodz
2017-2024
Laboratory of Molecular Genetics
2018-2020
Temple University
2013
Lodz University of Technology
2005
Essential oils obtained from the NR (normal roots) and HR (hairy of medicinal plant Leonurus sibiricus root were used in this study. The essential oil compositions detected by GC‐MS. Eighty‐five components identified total. Seventy for oil. major constituents β ‐selinene (9.9%), selina‐4,7‐diene (9.7%), (E) ‐ ‐caryophyllene (7.3%),myli‐4(15)‐ene (6.4%), guaia‐1(10),11‐diene (5.9%). Sixty‐seven oil, main being (22.6%), germacrene D (19.8%). tested cytotoxic effect, antimicrobial,...
Bee venom is a very complex mixture produced and secreted by the honeybee (Apis mellifera). Melittin major component of bee that accounts for about 52% its dry mass. A vast number studies have been dedicated to effects melittin's regulation apoptosis factors induce in various types cancer such as breast, ovarian, prostate, lung. The latest evidence indicates potential therapeutic agent treatment leukaemia. aim our present study evaluate ability leukaemia cell lines different origin acute...
Background:Depressive disorder (DD), including recurrent DD (rDD), is a severe psychological disease, which affects large percentage of the world population.Although pathogenesis disease not known, growing body evidence shows that inflammation together with oxidative stress may contribute to development DD.Since reactive oxygen species produced during damage DNA, we wanted evaluate extent DNA and efficiency repair in patients depression. Material/Methods:We measured compared endogenous...
Menyanthes trifoliata L. has been used in traditional medicine for centuries. It exists Asia, Europe, North America and Morocco is exploited as a remedy anemia lack of appetite. This plant shows many pharmacological properties, but its most interesting one anti-cancer potential. The present study examines the induction apoptosis grade IV glioma cells after treatment with extracts from aerial part root M. plants derived vitro (MtAPV MtRV, respectively) soil (MtAPS MtRS, presents first...
XRCC2 and XRCC3 proteins are structurally functionally related to RAD51 which play an important role in the homologous recombination, process frequently involved cancer transformation. In our previous work we show that 135G>C polymorphism (rs1801320) of gene can modify effect Thr241Met (rs861539) gene. We tested association between gene, Arg188His (rs3218536) colorectal risk clinicopathological parameters. Polymorphisms were evaluated by restriction fragment length polymerase chain reaction...
Abstract Tryptophan catabolites pathway disorders are observed in patients with depression. Moreover, single nucleotide polymorphisms of tryptophan hydroxylase genes may modulate the risk depression occurrence. The objective our study was to confirm association between presence polymorphic variants TPH 1 and 2 genes, development depressive disorders. Six were selected: c.804‐7C>A (rs10488682), c.‐1668T>A (rs623580), c.803+221C>A (rs1800532), c.‐173A>T (rs1799913)— , c.‐1449C>A...
Leonurus sibiricus L. is a traditional medicinal plant which occurs in southern Siberia, China, Korea, Japan, and Vietnam. The shows several pharmacological effects, but the most interesting its anti-cancer activity. aim of our study was to examine induction apoptosis malignant glioma cells, aggressive primary brain tumors central nervous system, following treatment with transformed root (TR) or non-transformed (NR) extracts. Both NR TR extracts were found have cytotoxic activity cells....
Zinc plays an essential role in a wide range of cellular processes, including defense against free radicals and maintaining genomic stability. The presence zinc some proteins is fundamental for their functioning as transcription factors. Little known about interaction between DNA, which can be important light reports on the cancer transformation sometimes contradictory character these reports. In present study we studied cyto- genotoxicity sulfate (ZnSO(4)) normal human lymphocytes...
Leonurus sibiricus L. has been used as a traditional and medicinal herb for many years in Asia Europe. This species is known to have antibacterial, anti‐inflammatory, antioxidant activity demonstrated reduction of intracellular reactive oxygen species. All tested extracts showed protective DNA repair stimulating effects Chinese hamster ovary (CHO) cells exposed H 2 O . Preincubation the CHO with 0.5 mg/mL plant increased expression level genes ( SOD2, CAT, GPx ). LC‐MS/MS HPLC analyses...
Nitric oxide (NO) is one of the most important signal molecules, involved in both physiological and pathological processes. As a neurotransmitter central nervous system, NO regulates cerebral blood flow, neurogenesis, synaptic plasticity. The aim our study was to investigate effect extremely low‐frequency electromagnetic field (ELF‐EMF) on generation metabolism NO, as neurotransmitter, rehabilitation poststroke patients. Forty‐eight patients were divided into two groups: ELF‐EMF non‐ELF‐EMF....