A5048838605- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Nanoparticles: synthesis and applications
- Genetics, Aging, and Longevity in Model Organisms
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Advanced Nanomaterials in Catalysis
- Selenium in Biological Systems
- Phagocytosis and Immune Regulation
- Gold and Silver Nanoparticles Synthesis and Applications
- Liver physiology and pathology
- Air Quality and Health Impacts
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Immune cells in cancer
Mario Negri Institute for Pharmacological Research
2021-2025
Institut Químic de Sarrià
2025
Universitat Ramon Llull
2025
Istituti di Ricovero e Cura a Carattere Scientifico
2022
Preventing relapse after resection of a primary tumor continues to be an unmet clinical need. Development adjuvant biomaterials with the capacity kill residual cancer cells is importance. Here we developed library metallo-alginate hydrogels containing high concentrations metallic ions such as Ca2+ in combination Zn2+, Li+, or Mg2+ disrupt homeostasis mitochondria by local hyperthermia. To synergistically and suppress growth rechallenged tumors, embedded oncogene-silencing nucleic acids (mTOR...
Abstract Macrophages are crucial drivers of innate immunity. Reprogramming macrophages to a restorative phenotype in cancer or autoimmune diseases can stop their cancer‐promoting activity trigger anti‐inflammatory Glycans have emerged as key components for immunity they involved many pathophysiological disorders. Previous studies demonstrated that supraphysiological amounts mannose (Man) sialic acid (Sia) inhibit tumor growth and stimulate differentiation regulatory T cells. Man is known...
Over the last years, advancements in use of nanoparticles for biomedical applications have clearly showcased their potential preparation improved imaging and drug-delivery systems. However, compared to vast number currently studied such applications, only a few successfully translate into clinical practice. A common "barrier" that prevents from efficiently delivering payload target site after administration is related liver filtering, mainly due nanoparticle uptake by macrophages. This work...
Food-grade titanium dioxide (E171) contains variable percentages of (TiO
Gold nanoparticles’ tropism towards the liver is affected by their size and aspect ratio, being co-localised inside lysosomes of hepatic cells, without changes in morphology or arising toxicity after 47 days administration.
Abstract Ultrasmall nanoparticles of 10 nm or less in size have been shown to great potential the biomedical field due their high surface area and strong tissue penetration. Their easy functionalization unique behavior at nanoscale, such as reduced corona formation lower liver retention allow them be a tool for precision targeting. In this study, PEGylated ultrasmall gold (GNPs) with 4 core are developed. They functionalized cyclic RGD (cRGD) targeting peptide, which provides binding...