A5092799709- Photoacoustic and Ultrasonic Imaging
- Nanoplatforms for cancer theranostics
- Gold and Silver Nanoparticles Synthesis and Applications
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- Infrared Thermography in Medicine
- Advanced biosensing and bioanalysis techniques
Mario Negri Institute for Pharmacological Research
2023-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Abstract Macrophages are crucial drivers of innate immunity. Reprogramming macrophages to a restorative phenotype in cancer or autoimmune diseases can stop their cancer‐promoting activity trigger anti‐inflammatory Glycans have emerged as key components for immunity they involved many pathophysiological disorders. Previous studies demonstrated that supraphysiological amounts mannose (Man) sialic acid (Sia) inhibit tumor growth and stimulate differentiation regulatory T cells. Man is known...
The emergence of SARS-CoV-2 in Wuhan, China 2019 has had a profound impact on humanity every facet. While vaccines against this viral pathogen have been approved year later, limitations to therapeutic intervention persist, such as drug sensitivity transportation and storage conditions, well significant financial losses from non-injected resuspended vials. Our research delves into the effects thermal denaturation (4 – 40°C) light irradiation (720 10460 kJ/m2) mRNA-based BNT162b2...
Nanodecoy systems based on analogues of viral cellular receptors assembled onto fluid lipid-based membranes nano/extravescicles are potential new tools to complement classic therapeutic or preventive antiviral approaches. The need for transmembrane receptor anchorage may pose technical challenges along industrial translation, calling alternative geometries multimerization. Here we developed a semisynthetic self-assembling SARS-CoV-2 nanodecoy by multimerizing the biotin labelled virus cell...
In this study, we devised the characterization of thermal outcome gold nanorods (AuNRs)-mediated photothermal therapy (PTT) in triple-negative murine 4T1 cell line, employed as a model breast cancer. After examining characteristics AuNRs and their internalization into cells, monitored real-time effects on cells upon vitro AuNRs-mediated PTT exploiting high-performant thermographic imaging. Multiple parameters, such temperature evolution, maximum attained during laser exposures, normalized...