A5005245556- Nanoparticle-Based Drug Delivery
- Dendrimers and Hyperbranched Polymers
- Phagocytosis and Immune Regulation
- Neuroscience and Neural Engineering
- Adenosine and Purinergic Signaling
- Immune Cell Function and Interaction
- Immune cells in cancer
- SARS-CoV-2 detection and testing
- Conducting polymers and applications
- Amyotrophic Lateral Sclerosis Research
- Advanced biosensing and bioanalysis techniques
- Immunotherapy and Immune Responses
- Alzheimer's disease research and treatments
- Biotin and Related Studies
- Parkinson's Disease Mechanisms and Treatments
- SARS-CoV-2 and COVID-19 Research
- Synthesis and Biological Evaluation
- Advanced Nanomaterials in Catalysis
- Nanoparticles: synthesis and applications
- Advanced Cellulose Research Studies
- Bone Tissue Engineering Materials
- Cell Adhesion Molecules Research
Mario Negri Institute for Pharmacological Research
2020-2025
University of Milano-Bicocca
2023
Istituti di Ricovero e Cura a Carattere Scientifico
2023
Abstract Macrophages are crucial drivers of innate immunity. Reprogramming macrophages to a restorative phenotype in cancer or autoimmune diseases can stop their cancer‐promoting activity trigger anti‐inflammatory Glycans have emerged as key components for immunity they involved many pathophysiological disorders. Previous studies demonstrated that supraphysiological amounts mannose (Man) sialic acid (Sia) inhibit tumor growth and stimulate differentiation regulatory T cells. Man is known...
Aim: We investigated the use of cellulose nanocrystals (CNCs) as drug nanocarriers combining an anti-osteoporotic agent, alendronate (ALN), and anti-cancer drug, doxorubicin (DOX). Materials & methods: CNC physicochemical characterization, in vivo imaging coupled with histology vitro uptake toxicity assays were carried out. Results: In CNC-ALN did not modify bone tropism lung penetration, whereas its liver kidney accumulation was slightly higher compared CNCs alone. studies showed that...
The development of nanoparticles (NPs) to enable the passage drugs across blood–brain barrier (BBB) represents one main challenges in neuropharmacology. In recent years, NPs that are able transport and interact with brain endothelial cells have been tested. Here, we investigated whether functionalization avidin-nucleic-acid-nanoassembly (ANANAS) apolipoprotein E (ApoE) would allow BBB SOD1G93A mouse model amyotrophic lateral sclerosis. Our results demonstrated ANANAS was transiently cross...
Titanium dioxide nanoparticles (TiO2 NPs) are one of the main sources nanoparticulate matter exposure to humans. Although several studies have demonstrated their potential toxic effects, real nature correlation between NP properties and interaction with biological targets is still far from being fully elucidated. Here, engineered TiO2 NPs various geometries (bipyramids, plates, rods) been prepared, characterized intravenously administered in healthy mice. Parameters such as biodistribution,...
Nanodecoy systems based on analogues of viral cellular receptors assembled onto fluid lipid-based membranes nano/extravescicles are potential new tools to complement classic therapeutic or preventive antiviral approaches. The need for transmembrane receptor anchorage may pose technical challenges along industrial translation, calling alternative geometries multimerization. Here we developed a semisynthetic self-assembling SARS-CoV-2 nanodecoy by multimerizing the biotin labelled virus cell...
Abstract Ultrasmall nanoparticles of 10 nm or less in size have been shown to great potential the biomedical field due their high surface area and strong tissue penetration. Their easy functionalization unique behavior at nanoscale, such as reduced corona formation lower liver retention allow them be a tool for precision targeting. In this study, PEGylated ultrasmall gold (GNPs) with 4 core are developed. They functionalized cyclic RGD (cRGD) targeting peptide, which provides binding...