A5076614469- Nigella sativa pharmacological applications
- Heavy Metal Exposure and Toxicity
- Natural Antidiabetic Agents Studies
- Arsenic contamination and mitigation
- Bioactive Compounds and Antitumor Agents
- Diet, Metabolism, and Disease
- Natural Compounds in Disease Treatment
- Coffee research and impacts
- Selenium in Biological Systems
- Synthesis and biological activity
- Chemotherapy-induced organ toxicity mitigation
- Folate and B Vitamins Research
- Medicinal Plants and Neuroprotection
- Inflammatory mediators and NSAID effects
- Sperm and Testicular Function
- Ziziphus Jujuba Studies and Applications
- Sexual function and dysfunction studies
- Nanoparticles: synthesis and applications
- Advances in Oncology and Radiotherapy
- Saffron Plant Research Studies
- Schizophrenia research and treatment
- Phytochemistry and biological activity of medicinal plants
- Genomics, phytochemicals, and oxidative stress
- Cardiomyopathy and Myosin Studies
- Inflammasome and immune disorders
Helwan University
2013-2024
Suez University
2024
Galala University
2022-2024
Ollscoil na Gaillimhe – University of Galway
2016
Sana'a University
2012
Green coffee consumption has been stated to have a converse association with type 2 diabetes and metabolic syndrome. Hence, we assessed changes produced by the administration of different doses green on biomarkers related renal antioxidant systems. The study was carried out 42 diabetic male albino rats; high-fat diet (HFD) single dose streptozotocin (STZ; 35 mg kg−1) were utilized for model induction. Diabetic rats received water extract (GCWE; 50 100 daily 28 days. GCWE caused remarkable...
Arsenic is a potent neurotoxic xenobiotic found in drinking water, and food. Chlorogenic acid (CGA), an abundant polyphenol coffee, potentially has wide range of therapeutic benefits. This study aimed to explore the mechanism detail neuroprotection provided by CGA against arsenite-induced toxicity mice underlying mechanisms involved. The were randomly divided into five groups; control, (200 mg/kg), arsenite (5 (100 mg/kg) + arsenite, arsenite. All animals treated daily for four weeks....
Inflammation is an essential defense mechanism against harmful stimuli. However, uncontrolled inflammatory mechanisms culminate in disturbed responses that contribute to multiple serious diseases. Besides common synthetic drugs, there a growing interest optimizing the use of natural products as therapeutic or protective supplements disorders. Black cumin seed (BCS), Nigella sativa (Family Ranunculaceae), widely used health-supportive herb Middle East, Far East and West Asia. BCS rich source...
Diallyl disulfide (DADS) is the major organosulfur constituent in garlic, with a variety of pharmacological activities including antioxidant and anti-inflammatory. Here, we examined potential antiedematous impact DADS- versus carrageenan-mediated paw edema mice. Carrageenan injection potentiated an inflammatory reaction as presented by elevated serological C-reactive protein (CRP) levels transcription tumor necrosis factor-alpha (TNF- α , Tnf ), interleukin-1 beta (IL-1 β Il1b),...
Abstract BACKGROUND Chronic exposure to arsenic (As) leads serious renal disorders. Chlorogenic acid (CGA), a phenolic compound, has several well known physiological benefits, including antioxidant and anti‐inflammatory activities. The present study investigated the potential renoprotective effects of CGA on sodium arsenite (NaAsO 2 )‐induced kidney damage in mice. mice were randomly allocated into five groups receive daily treatment with (200 mg kg −1 ), NaAsO (5 + (100 or control for 28...
The aim of this study is to investigate the protective effects thymoquinone (TQ) and ebselen (Eb) on arsenic (As)-induced renal toxicity in female rats. Sodium arsenite was orally administrated at a dose 20 mg/kg body weight daily for 28 days, either alone or 1 h before TQ (10 mg/kg) Eb (5 administration. Renal tissue As concentration oxidative stress markers, including lipid peroxidation (LPO), nitrite/nitrate, glutathione (GSH) levels, were determined. In addition response, antioxidant...
Cadmium (Cd) is a common environmental toxicant that has harmful effects on plants, animals, and humans. The present study evaluated the protective of Fragaria ananassa methanolic extract (SME) cadmium chloride (CdCl2)-induced neuronal toxicity in rats. Male albino rats were intraperitoneally (i.p) injected with CdCl2 (6.5 mg/kg) for 5 days or without SME (250 mg/kg). We measured levels Cd, lipid peroxidation (LPO), nitric oxide, glutathione (GSH), oxidative enzymes such as superoxide...
Diabetes mellitus (DM) is a chronic endocrine disease characterized by persistent hyperglycemia. Oxidative damage, inflammatory cytokines, and apoptotic cell death play major role in the induction progression of male testicular damage. Plant-derived phytochemicals such as green coffee (Coffea arabica) can possess antidiabetic effects with little toxicity. The current study aimed at investigating therapeutic roles diabetic injury stimulated high-fat diet/streptozotocin administration. was...
The present study aimed to test the anti-inflammatory and xanthine oxidase inhibitory activities of two synthesized molecules compare them routinely prescribed nonsteroidal drugs (NSAIDs), such as diclofenac serum urate-lowering drug, allopurinol. effects designed compounds (A B) were evaluated in carrageenan (CAR)-induced paw edema mice. levels nitric oxide myeloperoxidase activity measured skin using biochemical methods. Additionally, prostaglandin E2 (PGE2), C-reactive protein (CRP),...
The goal of the current study was to examine therapeutic potential green coffee bean extract (GCBE) in treatment diabetic hepatic damage induced by high-fat diet (HFD) and streptozotocin (STZ) administration. novelty this lies constructing a newly stabilized vivo obese animal model rats using HFD/STZ for investigating dose-dependent effect two commonly used doses GCBE hepatoprotection against oxidative stress-induced measuring many parameters that have not been carried out previously other...
In this research, we exploited derivatives of thieno[2,3-b]pyridine as dual inhibitors the key enzymes in eicosanoid biosynthesis, cyclooxygenase (COX, subtypes 1 and 2) 5-lipoxygensase (5-LOX). Testing these compounds a rat paw oedema model revealed potency higher than ibuprofen. The most active 7a, 7b, 8b, 8c were screened against COX-1/2 5-LOX enzymes. Compound 7a was powerful inhibitor with IC50 = 0.15 µM, while its p-chloro analogue 7b more COX-2 (IC50 7.5 µM). less desirable target...
Glomerular filtration rate and/or creatinine are not accurate methods for renal failure prediction. This study tested homocysteine (Hcy) as a predictive and prognostic marker end stage disease (ESRD). In total, 176 subjects were recruited divided into: healthy normal group (108 subjects); mild-to-moderate impaired function (21 patients); severe (7 chronic (40 patients) who on regular hemodialysis. Blood samples collected, serum was separated analysis of total Hcy, creatinine, high sensitive...
PDE5 inhibitors (PDE5inhs) have proven to be of great impact in the treatment numerous human extra-sexual diseases and their chronic use may induce endothelial rehabilitation. This study aimed assess effects PDE5inhs at administration explore possible cyto-protective thrombo-resistance effects.One hundred New Zealand white male rabbits were divided into four groups. The first group (control, C) received 1 ml saline/kg, second (S) 10 mg/kg sildenafil, third (V) 2 vardenafil, fourth (T)...
Acute hepatitis is characterized by acute hepatic parenchymal inflammation, raising liver function indices, and offering little chance of successful treatment. Consequently, there a lot curiosity in the discovery natural products as valuable alternatives to traditional anti-inflammatory agents with inhibitory effect, especially on cyclooxygenase-2 (COX-2) 5-lipoxygenase (5-LO). Black cumin seed oil (BCSO) possesses antioxidant properties due constituent thymoquinone (TQ). The protective BCSO...
Background: Acute kidney injury (AKI) is a medical concern that accompanied by the rapid deterioration of function. It can be triggered lipopolysaccharide (LPS) gram-negative bacteria as it activates complicated immune response, resulting in widespread inflammation and potential organ dysfunction. Black seed oil (BSO) rich beneficial constituents has been widely used owing to its nutritional advantages. Purpose: This research aimed investigate protective effects BSO nano-formulation on AKI...
In this study, the biochemical effects of Catha edulis leaves chewing (as psycho stimulant and aphrodisiac) on serum concentration resistin, insulin, cortisol, zinc, calcium, copper blood glucose in both healthy individuals type 2 diabetic patients were examined. 80 male subjects aged 35-55 years recruited 40 them previously diagnosed as diabetics other non-diabetics. The above two groups subdivided into subgroups (n = 20) accordance whether they regular chronic khat chewers or none NNK;...