The main purpose of this study was to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS) Olmesartan (OLM) for enhancement its solubility and dissolution rate. In study, liquid SNEDDS containing formulated further developed into form by the spray drying technique using Aerosil 200 as carrier. Based on preliminary screening different unloaded formulae, eight formulae OLM loaded SNEEDS were prepared Capryol 90, Cremophor RH40 Transcutol HP oil, surfactant cosurfactant,...

Miconazole nitrate (MIC) is an antifungal drug used for treatment of superficial fungal infections. However, it has low skin permeability. Hence, the objective this study was to prepare miconazole using Transfersomes overcome barrier function skin. MIC were prepared a thin lipid film hydration technique. The evaluated with respect entrapment efficiency (EE%), particle size, and quantity in vitro released obtain optimized formulation. formulation incorporated into Carbapol 934 gel base which...

Diabetes mellitus is a chronic metabolic disorder that exhibited great expansion all over the world. It becoming an epidemic disease adding major burden to health care system, particularly in developing countries.The plant under investigation current study Phragmanthera austroarabica A. G. Mill and J. Nyberg traditionally used Saudi Arabia for treatment of diabetes mellitus. The methanolic extract (200 mg/kg) pure gallic acid (40 mg/kg), metabolite plant, as well their silver nanoparticle...

(1) Background: Thymus vulgaris L. (thyme) essential oil (TEO) has gained much attention because of its long history medicinal usage. However, the lack precise chemical profiling TEO and methods to optimize bioactivity delivery constituents hampered research on quality control biological function; (2) Methods: The current study aimed analyze TEO's composition using GC-MS method identify key components. Another objective this work is impact protective layer amphiphilic oligochitosan (AOC)...

The objective of this study was to formulate and evaluate valsartan (VLT) ethosomes prepare an optimized formula VLT-entrapped that could be incorporated into a sustained release transdermal gel dosage form. formulation the prepared ethosomal investigated subjected in vitro drug studies, ex vivo test, studies assess effectiveness enhancing bioavailability VLT as poorly soluble controlling its from acquired results are follows: Dependent responses were particle size, polydispersity index,...

Objectives: The study aimed to prepare carbamazepine in solid lipid nanoparticle form (CBZ-SLN) order enhance its anticonvulsant effect. Method: Eight formulations of CBZ-SLNs were prepared by homogenization and ultra-sonication techniques. Results: CBZ-SLN showed a high entrapment efficiency% (39.66 ± 2.42%-71.91 1.21%), small particle size (45.11 6.72-760.7 5.25 nm), negative zeta potential (from -21.5 1.02 -38.4 1.32 mv). vitro release the slow CBZ from SLNs compared aqueous dispersion (p...

Treatment of dermatophytosis is quite challenging. This work aims to investigate the antidermatophyte action Azelaic acid (AzA) and evaluate its efficacy upon entrapment into transethosomes (TEs) incorporation a gel enhance application. Optimization formulation variables TEs was carried out after preparation using thin film hydration technique. The activity AzA-TEs first evaluated in vitro. In addition, two guinea pig infection models with Trichophyton (T.) mentagrophytes Microsporum (M.)...

Over the last few years, there has been a significant consideration of solid lipid nanoparticles (SLNs) as an alternative method to other colloidal dispersion methods for drug delivery. Special given use SLNs carrier in recent years. are aqueous dispersions which particles consist lipids that biodegradable. As result their physical stability, protection entrapped from decomposition, provision controlled release, and exceptional acceptability, have several advantages over carriers. This...

Cancer is a multifactorial disease necessitating identification of novel targets for its treatment. Inhibition Bcl-2 triggered pro-apoptotic signaling considered promising strategy cancer Within the current work, we aimed to design and synthesize new series benzimidazole- indole-based derivatives as inhibitors protein. The market pan-Bcl-2 inhibitor, obatoclax, was lead framework compound adopted structural modifications. obatoclax’s pyrrolylmethine linker replaced with straight alkylamine...

The aim of the current study is to establish a comprehensive experimental design for screening and optimization Atorvastatin-loaded nanostructured lipid carriers (AT-NLCs). Initially, combined D-optimal was applied find most significant factors affecting AT-NLCs properties. studied variables included mixtures solid liquid lipids, solid/liquid ratio, surfactant type concentration, homogenization speed as well sonication time. Then, (A), ratio lipid/liquid (B), concentration (C) were optimized...

(1) Background: Virgin olive oil (VOO) has attracted the attention of many researchers due to its nutritional and medicinal values. However, VOO's biological applications have been limited a lack precise chemical profiling approach increase physicochemical characteristics, bioactivity, delivery bioactive components; (2) Methods: The current study intended evaluate composition VOO using GC-MS technique determine major components. Furthermore, effect incorporating into Tween 80-lecithin...

Glimepiride is an antidiabetic drug which one of the third generation sulfonylureas. It belongs to class II, according BCS (Biopharmaceutical Classification System), characterized by low solubility and high permeability. The aim this work was formulate glimepiride as solid dispersion using water-soluble carriers enhance its aqueous thus bioavailability. Nine formulations were prepared a solvent evaporation technique three different (mannitol, polyethylene glycol 6000, β-cyclodextrin) with...

Drug absorption from the gastrointestinal tract (GIT) is one of major problems affecting bioavailability orally absorbed drugs. This work aims to enhance Fexofenadine HCl oral in vivo, drug used for allergic rhinitis. In this study, novel spray-dried lactose-based enhanced situ forming vesicles were prepared using different enhancer by slurry method. Full factorial design was obtain an optimized formulation, while central composite develop economic, environment-friendly analysis method...

Cynara scolymus L. (Family: Compositae) or artichoke is a nutritious edible plant widely used for its hepatoprotective effect. Crude extracts of flower, bract, and stem were prepared evaluated their in vitro antioxidant activity phenolic content. The flower crude extract exhibited the highest content (74.29 mg GAE/gm) as well best using total capacity (TAC), ferric reducing power (FEAP), 1,1-diphenyl-2-picrylhyazyl (DPPH) scavenging assays compared with ascorbic acid. Phenolic fractions...

Different parts of Cynara scolymus L. and their green synthesized eco-friendly silver nanoparticles (AgNPs) were screened for cytotoxicity apoptotic activity. Results showed that flower extract AgNPs exhibited more potent compared to the normal form against PC-3 A549 cell lines with IC50 values 2.47 μg/mL 1.35 μg/mL, respectively. The results doxorubicin (IC50 = 5.13 6.19 respectively). For apoptosis-induction, prepared from induced death by apoptosis 41.34-fold change necrotic 10.2-fold....

Background: Acute kidney injury (AKI) is a medical concern that accompanied by the rapid deterioration of function. It can be triggered lipopolysaccharide (LPS) gram-negative bacteria as it activates complicated immune response, resulting in widespread inflammation and potential organ dysfunction. Black seed oil (BSO) rich beneficial constituents has been widely used owing to its nutritional advantages. Purpose: This research aimed investigate protective effects BSO nano-formulation on AKI...

The current work demonstrates a comparative study between aerial and root parts of Zygophyllum album L. total phenolic (TPC) flavonoid content (TFC), in addition to the antioxidant activity, crude extracts were investigated, where revealed higher value overall. By means UV-VIS HPLC, rutin caffeic acid detected then quantified as 5.91 0.97 mg/g plant extract, respectively. Moreover, biosynthesis AgNPs utilizing extract arial Z. was achieved an attempt enhance cytotoxicity different extracts....

Objective: In the present investigation efforts were considered to optimize different conditions for preparation of spray dried lactose based proniosomes. The aim this research was investigate feasibility proniosomes as stable precursors development niosomes oral drug delivery system poorly water-soluble drugs.Methods: A total twenty-eight plain proniosomal formulae prepared with various surfactant-cholesterol loading ratios in each formula using a carrier. Span 20, 40, 60 and 80 used molar...

Introduction: Several recent studies have shown that the role of cyclooxygenase 2 (COX-2) in carcinogenesis has become more evident. It affects angiogenesis, apoptosis, and invasion, plays a key production carcinogens. also been reported COX-2 inhibitors such as celecoxib (CLX) might play an effective preventing cancer formation progression. Formulation CLX into nanovesicles is promising technique to improve its bioavailability anticancer efficacy. Aim: The aim this study optimize evaluate...

A serial method is described for estimating the particle effective density and dynamic shape factor of particles, i.e., diesel exhaust particles (DEPs). For this purpose, we designed a single stage low-pressure impactor with cutoff diameter 130 nm. The collection efficiency curve was obtained using mobility-classified sodium chloride (NaCl) as function mobility diameter. Then by converting NaCl into aerodynamic equivalent diameter, can be expressed We also numerically commercial...

Lipid oxidation and microorganism growth cause a reduction in cupcake qualities. Because of the harmful effects synthetic preservatives, there is growing demand for preservatives natural antioxidants. In this study, phytochemical properties antimicrobial activity Emblica oficinalis (amla) were investigated. Then effect adding amla extract at levels 1, 2, 3% on qualitative attributes cupcakes was examined. produced samples, antioxidant compared by assessing DPPH%, peroxide values, free fatty...