The aim of the current study is to establish a comprehensive experimental design for screening and optimization Atorvastatin-loaded nanostructured lipid carriers (AT-NLCs). Initially, combined D-optimal was applied find most significant factors affecting AT-NLCs properties. studied variables included mixtures solid liquid lipids, solid/liquid ratio, surfactant type concentration, homogenization speed as well sonication time. Then, (A), ratio lipid/liquid (B), concentration (C) were optimized...

A field experiment was conducted at the Farm of Kafr-El-Hamam Research Station, Zagazig, Sharkia Governorate, Agricultural Center, Egypt during two successive summer seasons 2015 and 2016 to achieve highest yield good oil quality three tested sunflower genotypes. In both seasons, using split plot design in randomized complete block with replicates arrangement keeping plant spaces (15, 20 25 cm apart between hills) main plots, nitrogen fertilization levels 30 45 N fad.−1) sub plots genotypes...

Twenty-one hybrids of sunflower were produced by crossing 7 introduced cytoplasmic male sterile lines (CMS-lines) with 3 restorer (RF-lines) using line × tester mating design. The twenty-one hybrids, three restorers, seven maintainer (B-lines) evaluated. experiment was conducted in a randomized complete block design replications. Mean squares due to genotypes, parents (P), crosses (C), (L), testers (T), P vs. C, for stearic acid and palmitic acid. inbred their F 1 differed significantly mean...

To determine the genetic control of seed yield and yield-related traits by using Hayman’s approach, to estimate proportion dominant recessive genes controlling in each parent, five genetically divergent genotypes sunflower (Helianthus annuus L.) were crossed a half-diallel mating design (excluding reciprocal crosses). The parents along with their crosses evaluated randomized complete block three replicates at Kafr El-Hamam/Sharkia Al-Arish/North Sinai Agricultural Research Stations, Center,...

Abstract Simultaneously identify superior performing in terms of seed yield and oil content broad adaptation across a wide range different environments is an important target for sunflower breeder. So, 10 genotypes were evaluated the eight various created by sowing at four locations i. e. Kafr El Hamam/ Sharkia, Shandaweel /Sohag, Tag Ezz/ Dakahlia Al Arish/ North Sinai Agricultural Research Stations, Center (ARC), Egypt during two successive summer seasons 2018 2019 using randomized...

Oral administration is widely accepted drug delivery system however, its use limited due to physico-chemical properties of the such as poor solubility, low permeability, instability, and rapid metabolism all which decrease oral bioavailability.The bioavailability most drugs still a major obstacle creates challenges for pharmaceutical manufacturers design with improved pharmacokinetics profile therapeutic responses.The fundamental problem over years has been develop techniques that will allow...

The majority of the pharmaceutically active chemical moieties represent a challenge in their formulation. Most these drugs have intricate bioavailability issues either related to low solubility or permeability. Many problems may arise during formulations such as pH dependent ionization, poor drug solubility, limited absorption, unpredicted bioavailability, degradation, metabolism, and cellular efflux. Poor aqueous is determinate criterion, formulation Biopharmaceutical Classification System...

To detect types of gene action especially epistasis for studied traits, six populations; P1, P2, F1, F2, BC1 and BC2 in two intraspecific crosses canola (N.A.37 × Serw 4 N.A.14 6) were evaluated a field trial during 2019/2020 season at Kafr-El-Hamam/Sharkia Al-Arish/North Sinai Agricultural Research Stations, Center, Egypt.Scaling joint scaling tests revealed inadequacy simple additive-dominance model the inheritance all traits corresponding both locations.Significant negative heterosis...

A field experiment was conducted in the contrasting locations of Kafr-El-Hamam/Sharkia and Al-Arish/North Sinai agricultural research stations Agricultural Research Center Egypt. We estimated additive dominance genetic variances, as well heritability broad narrow senses for sunflower yield its attributes cross L350 x L355 using North Carolina Design-III. The magnitude variances all studied traits at both proportion to phenotypic larger than variances. average degree greater unit, also...

The lung is an attractive target for drug delivery due to noninvasive administration via inhalation aerosols, avoidance of first-pass metabolism, direct the site action treatment respiratory diseases, and availability a huge surface area local systemic absorption drug.Nanocarrier systems in pulmonary offer many advantages such as potential achieve relatively uniform distribution dose among alveoli, achievement improved solubility from its own aqueous solubility, sustained release which...

Seven sunflower cytoplasmic male sterile (CMS lines) and three Rf-restorer (tester were used to obtain 21 F1 hybrids according line x tester mating design.All the hybrids, 7 lines, testers evaluated at Sakha Agricultural Research Station, Kafer El-Sheikh Governorate during 2017 season.The results showed highly significant differences among genotypes for all studied traits.The major role of dominant genes was found because degree dominance greater than unity.These indicated preponderance gene...

The present investigation was conducted to determine the genetic behavior of 14 genetically diverse genotypes sesame in Shandaweel Research Station (ARC), during two summer seasons 2017 and 2018, for seed yield their components using a randomized complete block design with 3 replications. Significant differences among evaluated all studied traits were observed. highest mean values 1000-seed weight yield/plant obtained from genotype M2A23, while lowest value B-42. Number branches per plant,...

The present study was conducted out to investigate the effect of foliar application five pea cultivars (Entesar 1, Goara, Line 11 and 14) with salicylic acid (SA) on infestation by Aphis craccivora (Koch.),Thrips tabaci Lindeman Liriomyza trifolii Burg.during 2018/2019 2019/2020 winter seasons at Sohag Governorate.Also, SA growth, yield, some yield components included.Data revealed that 200ppm 100ppm reduced A. craccivora, T. tabaci, L. (mines) infestations about 50% 30%, respectively,...