A5076487195- Extracellular vesicles in disease
- Computational Drug Discovery Methods
- RNA Interference and Gene Delivery
- Protein Degradation and Inhibitors
- MicroRNA in disease regulation
- SARS-CoV-2 and COVID-19 Research
- Peptidase Inhibition and Analysis
- CAR-T cell therapy research
- Virus-based gene therapy research
- Pharmacological Effects of Natural Compounds
- Drug Solubulity and Delivery Systems
- Medicinal Plants and Neuroprotection
- Reproductive System and Pregnancy
- Cholinesterase and Neurodegenerative Diseases
- Immunotherapy and Immune Responses
- Phytochemistry and Bioactive Compounds
- Multiple Myeloma Research and Treatments
- Bacillus and Francisella bacterial research
- Alzheimer's disease research and treatments
- COVID-19 Clinical Research Studies
- vaccines and immunoinformatics approaches
- Adipose Tissue and Metabolism
- Analytical Chemistry and Chromatography
- Traditional and Medicinal Uses of Annonaceae
- Phytochemistry and Bioactivity Studies
Saveetha University
2023-2025
Adamas University
2022-2024
Tripura University
2024
In the realm of cancer immunotherapy, a profound evolution has ushered in sophisticated strategies that encompass both traditional vaccines and emerging viral vaccines. This comprehensive Review offers an in-depth exploration methodologies, clinical applications, success stories, future prospects these approaches. Traditional have undergone significant advancements utilizing diverse modalities such as proteins, peptides, dendritic cells. More recent innovations focused on physiological...
As we navigate the modern era, intersection of time-honoured natural remedies and contemporary scientific approaches forms a burgeoning frontier in global healthcare. For generations, products have been foundational to health solutions, serving as primary healthcare choice for 80% 85% world's population. These herbal-based, nature-derived substances, significant across diverse geographies, necessitate renewed emphasis on enhancing their quality, efficacy, safety. In current century, advent...
The Semliki Forest Virus (SFV) is an RNA virus with a positive-strand that belongs to the Togaviridae family's Alphavirus genus. An epidemic was observed among French troops stationed in Central African Republic, most likely caused by SFV virus. two transmembrane proteins El and E2 peripheral protein E3 make up viral spike protein. binds host cell internalized via endocytosis; endosome acidification causes E1/E2 heterodimer dissociate E1 subunits trimerize. Lupenone evaluated against of this...
Helicobacter pylori (H. pylori) is a persistent bacterial inhabitant in the stomachs of approximately half global populace. This bacterium directly linked to chronic gastritis, leading heightened risk duodenal and gastric ulcer diseases, predominant factor for cancer - second most common cause cancer-related deaths globally. The increasing prevalence antibiotic resistance necessitates exploration innovative treatment alternatives mitigate H. menace.Initiating our study, we curated list...
Exosome-based targeted delivery of Proteolysis-Targeting Chimeras (PROTACs) is an innovative approach that provides a promising solution for addressing the complex issues viral diseases. This strategy significantly mitigates off-target effects associated with traditional therapeutics by facilitating PROTACs, which in turn enhances overall therapeutic outcomes. Challenges like poor pharmacokinetics and unintended side effects, commonly observed conventional PROTACs usage, are effectively...
Mosquitoes are the primary vector for West Nile virus, a flavivirus. The virus’s ability to infiltrate and establish itself in increasing numbers of nations has made it persistent threat public health worldwide. Despite widespread occurrence this potentially fatal disease, no effective treatment options currently on market. As result, there is an immediate need research development novel pharmaceuticals. To begin, molecular docking was performed two possible virus target proteins using panel...
The increase in diseases caused by RNA viruses, such as influenza, severe acute respiratory syndrome-coronavirus (SARS-CoV), Middle East syndrome (MERS), and Ebola, presents a growing global health challenge well the threat of zoonosis. Traditional antiviral treatments are often undermined fast-mutating drug resistance, newly emerging pathogens. Here, we explore proteolysis-targeting chimeras (PROTACs), novel protein degradation machinery that has potential to reshape way which viral...
Abstract Exosomes play a crucial role in intercellular communication and have emerged as significant vehicles for transporting disease‐specific biomarkers. This feature provides profound insights into the progression of diseases responses patients to treatments. For example, leukemia, exosomes convey critical information through carriage specific proteins nucleic acids. In case human papillomavirus (HPV)‐mediated cervical cancer, are particularly useful noninvasive detection they transport...
Alzheimer's disease (AD) is a severe neurodegenerative disorder of the brain that manifests as dementia, disorientation, difficulty in speech, and progressive cognitive behavioral impairment. The emerging therapeutic approach to AD management inhibition β-site APP cleaving enzyme-1 (BACE1), known be one two aspartyl proteases cleave β-amyloid precursor protein (APP). Studies confirmed association high BACE1 activity with proficiency formation β-amyloid-containing neurotic plaques,...
Heat shock protein 27 (HSP27) is a that works as chaperone and an antioxidant activated by heat shock, environmental stress, pathophysiological stress. However, HSP27 dysregulation characteristic of many human cancers. suppresses apoptosis cytoskeletal reorganization. As result, it recognized critical therapeutic target for effective cancer therapy. Despite the effectiveness multiple inhibitors in pre-clinical investigations clinical trials, no inhibitor has progressed to anticancer phase...
Alzheimer's disease (AD) is the most common neurodegenerative disorder in world, affecting an estimated 50 million individuals. The nerve cells become impaired and die due to formation of amyloid-beta (Aβ) plaques neurofibrillary tangles (NFTs). Dementia one symptoms seen people with AD. Genes, lifestyle, mitochondrial dysfunction, oxidative stress, obesity, infections, head injuries are some factors that can contribute development progression There just a few FDA-approved treatments without...
The increasing incidence of Monkeypox virus (Mpox) and Marburg (MARV) infections worldwide presents a significant challenge to global health, as limited treatment options are currently available. This study investigates the potential several O-rhamnosides Kaempferol-O-rhamnosides Mpox MARV inhibitors using molecular modeling methods, including ADMET, docking, dynamics/MD simulation. effectiveness these compounds against viruses was assessed Prediction Activity Spectra for Substances (PASS)...
The main objective of the present study was to improve solubility and dissolution rate felodipine (FLD), a drug that does not dissolve well in water, using self-nanoemulsifying delivery system (SNEDDS). Many analyses have been performed laboratory different oils, non-ionic surfactants, water-soluble co-solvents prepare FLD-loaded SNEDDS. It involves measurements viscosity, refractive index, droplet size. Solubility studies revealed best way load drugs, pseudo-ternary phase diagrams showed...
Personalized cancer immunotherapies, combined with nanotechnology (nano-vaccines), are revolutionizing treatment strategies, explicitly targeting Human papilloma virus (HPV)-related cancers. Despite the availability of preventive vaccines, HPV-related cancers remain a global concern. nano-vaccines, tailored to an individual's tumor genetic mutations, offer unique and promising solution. Nanotechnology plays critical role in these vaccines by efficiently delivering tumor-specific antigens,...
The global fight against Human Immunodeficiency Virus (HIV) and related viral infections stands at a pivotal juncture, demanding groundbreaking therapeutic strategies. Facing the challenges of existing antiviral treatments, such as resistance nonspecific actions, this paper unveils transformative approach. We introduce an innovative synergy between proteolysis-targeting chimeras (PROTACs) exosome-based delivery mechanisms, heralding era in combating HIV similar diseases. PROTACs emerge...
This study aimed to investigate the in vitro performance of self-nanoemulsifying drug delivery systems (SNEDDSs) Ornidazole (ORD), a poorly water-soluble drug. Self-nanoemulsifying ORD were prepared using various oils, non-ionic surfactants, and/or co-solvents and assessed visually/by droplet size measurement. Equilibrium solubility anhydrous diluted SNEDDS was conducted achieve maximum loading. The dissolution studied compare representative formulations with API. results from...
The authors declare no conflict of interest. Data sharing is not applicable to this article as new data were created or analyzed in study.
The evolving landscape of personalized medicine necessitates a shift from traditional therapeutic interventions towards precision-driven approaches. Embracing this paradigm, our research probes the efficacy aqueous crude extract (ACE) Calocybe indica in cervical cancer treatment, merging botanical insights with advanced molecular research. We observed that ACE exerts significant influences on nuclear morphology and cell cycle modulation, further inducing early apoptosis showcasing prebiotic...