A5010940724- Computational Drug Discovery Methods
- Synthesis and biological activity
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Inhalation and Respiratory Drug Delivery
- Complex Network Analysis Techniques
- Nanoparticle-Based Drug Delivery
- RNA and protein synthesis mechanisms
- Chemical Synthesis and Analysis
- Advanced Graph Neural Networks
- Protein Structure and Dynamics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Neurobiology and Insect Physiology Research
- Synthesis and Characterization of Heterocyclic Compounds
- Ion Channels and Receptors
- Click Chemistry and Applications
- Cholinesterase and Neurodegenerative Diseases
- RNA modifications and cancer
- Advancements in Transdermal Drug Delivery
- Liver Disease Diagnosis and Treatment
- Artificial Intelligence in Healthcare and Education
- Advanced Graph Theory Research
- MRI in cancer diagnosis
- Veterinary Medicine and Surgery
- Antibiotic Use and Resistance
Tishk International University
2020-2025
Rush University Medical Center
2024
Des Moines University Osteopathic Medical Center
2024
Tawam Hospital
2023
Government College University, Faisalabad
2023
Magyar Agrár- és Élettudományi Egyetem
2022
Capital University of Science and Technology
2017-2021
Bombay Veterinary College
2007-2021
John Wiley & Sons (United States)
2020
Balochistan University of Information Technology, Engineering and Management Sciences
2015-2019
Abstract Background Anxiety disorders comprise some of the most common mental health conditions. This study examined global and regional burden anxiety over last three decades. The was designed to help accurately target preventative management efforts by highlighting trends high-risk groups. Epidemiological data relating from latest Global Burden Disease dataset were analyzed determine prevalence, incidence, disability adjusted life years (DALYs) rates 1990 2019 for 204 countries regions....
Cancer, a life-disturbing and lethal disease with high global impact, causes significant economic, social, health challenges. Breast cancer refers to the abnormal growth of cells originating from breast tissues. Hormone-dependent forms cancer, such as those influenced by estrogen, prompt exploration estrogen receptors targets for potential therapeutic interventions. In this study, we conducted e-QSAR molecular docking dynamics analyses on diverse set inhibitors targeting receptor alpha...
Congruous coronavirus drug targets and analogous lead molecules must be identified as quickly possible to produce antiviral therapeutics against human (HCoV SARS 3CLpro) infections. In the present communication, we bear recognized a HIT candidate for HCoV 3CLpro inhibition. Four Parametric GA-MLR primarily based QSAR model (R2:0.84, R2adj:0.82, Q2loo: 0.78) was once promoted using dataset over 37 structurally diverse along virtual screening (QSAR-VS), molecular docking (MD) then dynamic...
ALK tyrosine kinase TK is an important target in the development of anticancer drugs. In present work, we have performed a QSAR analysis on dataset 224 molecules order to quickly predict activity query compounds. Double cross validation assigns upward plunge genetic algorithm−multi linear regression (GA-MLR) based robust univariate and multivariate models with high statistical performance reflected various parameters like, fitting parameters; R2 = 0.69−0.87, F 403.46−292.11, etc., internal...
Alzheimer's disease (AD) is a severe neurodegenerative disorder of the brain that manifests as dementia, disorientation, difficulty in speech, and progressive cognitive behavioral impairment. The emerging therapeutic approach to AD management inhibition β-site APP cleaving enzyme-1 (BACE1), known be one two aspartyl proteases cleave β-amyloid precursor protein (APP). Studies confirmed association high BACE1 activity with proficiency formation β-amyloid-containing neurotic plaques,...
ABSTRACT Despite advancements in molecular design rules and understanding biochemical processes, the field of drug discovery seeks to minimize number duration synthesis‐testing cycles convert lead compounds into candidates. A promising strategy involves gaining insightful key heteroatoms such as oxygen nitrogen. This work presents a comprehensive analysis atoms approved drugs, aiming streamline efforts. The study examines frequency, distribution, prevalence, diversity dataset 2049 small...
Background: Coronary angiography via the transradial approach is widely preferred due to its lower risk of bleeding and improved patient comfort. However, vascular complications such as radial artery occlusion transient or permanent loss pulse remain concerns. These can compromise future access impact procedural success. Understanding frequency, factors, recovery patterns post-procedure essential for optimizing management refining protocols enhance safety long-term arterial patency....
Background: An essential component of cell development, proliferation, and survival is the transmembrane receptor known as epidermal growth factor (EGFR). Dysregulated EGFR signalling an appealing pathway that has been linked to genesis progression several cancer types. tyrosine kinase inhibitors (TKIs) are targeted drugs show promise in fight against cancer. obstruct pathways by blocking receptor's domain. Patients with non-small lung (NSCLC) have mutations shown increased progression-free...
Obstructive jaundice is a significant clinical condition that requires timely and accurate diagnosis to guide appropriate management. Endoscopic Retrograde Cholangiopancreatography (ERCP) considered the gold standard but invasive associated with potential complications. Magnetic Resonance (MRCP) offers non-invasive alternative, its diagnostic accuracy warrants evaluation. Objective: To determine of MRCP in diagnosing obstructive using ERCP as reference standard. Methods: This prospective...
This study aims to determine the prevalence and susceptibility pattern of Pseudomonas aeruginosa multidrug-resistant (MDR) isolates in patients suffering from respiratory tract infection.A cross sectional was conducted January December 2014 Northwest General Hospital Research Centre, Peshawar. A total 615 sputum samples were collected both out-patients. Sputum as per standard procedure inoculated on Blood, MacConkey Chocolate agar. The identified by protocols using biochemical tests....
The aldose reductase (AR) enzyme is an important target in the development of therapeutics against hyperglycaemia induced health complications such as retinopathy, etc. In present study, a quantitative structure activity relationship (QSAR) evaluation dataset 226 reported AR inhibitor (ARi) molecules performed using genetic algorithm - multi linear regression (GA-MLR) technique. Multi-criteria decision making (MCDM) analysis furnished two five variables based QSAR models with acceptably high...
A lysine-specific demethylase is an enzyme that selectively eliminates methyl groups from lysine residues. KDM5A, also known as JARID1A or RBP2, belongs to the KDM5 Jumonji histone subfamily. To identify novel molecules interact with LSD5A receptor, we created a quantitative structure-activity relationship (QSAR) model. group of 435 compounds was used in study between structure and activity guess IC50 values for blocking LASD5A. We genetic algorithm-multilinear regression-based connection...
The ankyrin transient receptor potential channel TRPA1 is a non-selective cationic that expressed by sensory neurons, where it can be activated pungent chemicals, such as AITC (allyl isothiocyanate), cinnamon or allicin, deep cooling (<18 °C) highly depolarizing voltages (>+100 mV). From the cytoplasmic side, this regulated negatively charged ligands phosphoinositides inorganic polyphosphates, most likely through an interaction with yet unidentified positively domain(s). In present study, we...
Buparvaquone (BPQ), a hydroxynaphthoquinone derivative, has been investigated for the treatment of many infections and is recommended as gold standard theileriosis. Theileriosis, an intramacrophage infection localized mainly in reticuloendotheileial system (RES) organs. The present study investigates development solid lipid nanoparticles (SLN) BPQ targeted delivery to RES.BPQ SLN was prepared using melt method by adding molten mixture into aqueous Lutrol F68 solution (80°C). Larger batches...
Cisplatin, a platinum compound, exerts its cytotoxic effects by coordinating to DNA where it inhibits both replication and transcription, induces programmed cell death. It is used in the treatment of non-small lung cancer. In present study, an attempt was made achieve better cancer direct delivery cisplatin microparticulate systems, which helps localize drug lungs, also provide sustained action. Cisplatin-loaded chitosan microspheres were prepared emulsification ionotropic gelation method,...
The naturally occurring xanthone glycoside mangiferin has been isolated by column chromatography from the ethanol extract of stem bark Mangifera indica. Mangiferin was further converted to 5-(N-phenylaminomethyleno)mangiferin, 5-(N-p-chlorophenylaminomethyleno) mangiferin, 5-(N-2-methylphenylaminomethyleno) 5-(N-p-methoxyphenylaminomethyleno) 5-(N, N-diphenylaminomethyleno) 5-(N--napthylaminomethyleno) and 5-(N-4-methylphenylaminomethyleno) mangiferin. its analogues were characterized...
The aim of the present study was to evaluate possible gut inhibitory role phosphodiesterase (PDE) inhibitor roflumilast. Increasing doses roflumilast were tested against castor oil-induced diarrhea in mice, whereas pharmacodynamics same effect determined isolated rabbit jejunum tissues. For silico analysis, identified PDE protein docked with and papaverine using Autodock vina program from PyRx virtual screening tool. Roflumilast protected significantly at 0.5 1.5 mg/kg doses, 40% 80%...