A5079371665- Ion Channels and Receptors
- Neurobiology and Insect Physiology Research
- Phytochemicals and Antioxidant Activities
- Fungal and yeast genetics research
- RNA and protein synthesis mechanisms
- Ion channel regulation and function
- Protein Structure and Dynamics
- Plant Stress Responses and Tolerance
- RNA Research and Splicing
- Enzyme Structure and Function
- Cellular transport and secretion
- Insect Pest Control Strategies
- Photosynthetic Processes and Mechanisms
- Cancer-related gene regulation
- Postharvest Quality and Shelf Life Management
- Biochemical Analysis and Sensing Techniques
- Machine Learning in Bioinformatics
- Neonatal Health and Biochemistry
- Calcium signaling and nucleotide metabolism
- Biochemical and Molecular Research
- Cancer Research and Treatments
- Signaling Pathways in Disease
University of Warsaw
2017-2023
Czech Academy of Sciences
2012-2022
Czech Academy of Sciences, Institute of Microbiology
2015-2022
University of South Bohemia in České Budějovice
2012-2015
Czech Academy of Sciences, Global Change Research Institute
2012-2015
Cholesterol suppresses the activity of a channel needed to refill intracellular calcium stores.
Characterization of disease-associated Orai1 mutants reveals the multistep gating mechanism for CRAC channel.
The Ca(2+) release-activated channel mediates influx in a plethora of cell types, thereby controlling diverse cellular functions. complex is composed stromal interaction molecule 1 (STIM1), an endoplasmic reticulum Ca(2+)-sensing protein, and Orai1, plasma membrane channel. Channels STIM1 Orai1 mediate even at low extracellular concentrations. We investigated whether the activity adapted to different environmental used homology modeling molecular dynamics simulations predict presence...
The E. coli protein WrbA is an FMN-dependent NAD(P)H:quinone oxidoreductase that has been implicated in oxidative defense. Three subunits of the tetrameric enzyme contribute to each four identical, cavernous active sites appear accommodate NAD(P)H or various quinones, but not simultaneously, suggesting obligate tetramer with a ping-pong mechanism which NAD departs before oxidized quinone binds. present work was undertaken evaluate these suggestions and characterize kinetic behavior WrbA....
While the slipknot topology in proteins has been known for over a decade, its evolutionary origin is still mystery. We have identified previously overlooked motif family of two-domain membrane transporters. Moreover, we found that these are homologous to several families unknotted proteins. This allows us directly investigate evolution motif. Based on our comprehensive analysis 17 distantly related protein families, slipknotted and share common structural Furthermore, this conserved...
In baker's yeast (Saccharomyces cerevisiae), Trk1, a member of the superfamily K-transporters (SKT), is main K+ uptake system under conditions when its concentration in environment low. Structurally, Trk1 made up four domains, each similar and homologous to K-channel α subunit. Because most K-channels are proteins containing channel-building subunits, could be functional as monomer. However, related SKT TrkH KtrB were crystallised dimers, for tetrameric arrangement has been proposed based on...