A5056555353- Biofuel production and bioconversion
- Microbial Metabolic Engineering and Bioproduction
- Enzyme Catalysis and Immobilization
- Enzyme Production and Characterization
- Ion Channels and Receptors
- Neonatal Health and Biochemistry
- Postharvest Quality and Shelf Life Management
- Food composition and properties
- Microbial Fuel Cells and Bioremediation
- Photosynthetic Processes and Mechanisms
- Microbial Metabolites in Food Biotechnology
- biodegradable polymer synthesis and properties
- Calcium signaling and nucleotide metabolism
Dartmouth College
2016-2021
Dartmouth Hospital
2020
St. Jude Children's Research Hospital
2020
Bioenergy Life Science (United States)
2016
Oak Ridge National Laboratory
2016
Indian Institute of Technology Delhi
2013
Princeton University
2012
Leeds General Infirmary
2010
University of Leeds
2010
AstraZeneca (United Kingdom)
2010
Transient receptor potential melastatin (TRPM)3 is a calcium-permeable ion channel activated by the neurosteroid pregnenolone sulfate and positively coupled to insulin secretion in beta cells. Although vascular TRPM3 mRNA has been reported, there no knowledge of protein or its regulation function cardiovascular system.To determine relevance biology.TRPM3 expression was detected at levels contractile proliferating smooth muscle Calcium entry evoked sphingosine suppressed blocking antibody...
The fiber in corn kernels, currently unutilized the to ethanol process, represents an opportunity for introduction of cellulose conversion technology. We report here that Clostridium thermocellum can solubilize over 90% carbohydrate autoclaved fiber, including its hemicellulose component glucuronoarabinoxylan (GAX). However, Thermoanaerobacterium thermosaccharolyticum or several other described hemicellulose-fermenting thermophilic bacteria only partially utilize this GAX. describe isolation...
Abstract Background The cellulolytic thermophile Clostridium thermocellum is an important biocatalyst due to its ability solubilize lignocellulosic feedstocks without the need for pretreatment or exogenous enzyme addition. At low concentrations of substrate, C. can corn fiber > 95% in 5 days, but solubilization declines markedly at substrate higher than 20 g/L. This differs model cellulose like Avicel, on which maximum rate increases proportion concentration. goal this study was examine...
The E. coli protein WrbA is an FMN-dependent NAD(P)H:quinone oxidoreductase that has been implicated in oxidative defense. Three subunits of the tetrameric enzyme contribute to each four identical, cavernous active sites appear accommodate NAD(P)H or various quinones, but not simultaneously, suggesting obligate tetramer with a ping-pong mechanism which NAD departs before oxidized quinone binds. present work was undertaken evaluate these suggestions and characterize kinetic behavior WrbA....
Clostridium thermocellum and Thermoanaerobacterium saccharolyticum are bacteria under investigation for production of biofuels from plant biomass. has been engineered to produce ethanol at high yield (>90% theoretical) titer (>70 g/l). Efforts engineer C. have not, date, as successful, efforts underway transfer the pathway T. thermocellum. One potential challenge in transferring metabolic pathways is possibility incompatible levels nicotinamide cofactors. These cofactors (NAD+, NADH, NADP+...
Abstract Background The cellulolytic thermophile Clostridium thermocellum is an important biocatalyst due to its ability solubilize lignocellulosic feedstocks without the need for pretreatment or exogenous enzyme addition. At low concentrations of substrate, C. can corn fiber >95% in 5 days, but solubilization declines markedly at substrate higher than 20 g/L. This differs model cellulose like Avicel, on which maximum rate increases proportion concentration. goal this study was examine...
Abstract BackgroundThe cellulolytic thermophile Clostridium thermocellum is an important biocatalyst due to its ability solubilize lignocellulosic feedstocks without the need for pretreatment or exogenous enzyme addition. At low concentrations of substrate, C. can corn fiber >95% in 5 days, but solubilization declines markedly at substrate higher than 20 g/L. This differs model cellulose like Avicel, on which maximum rate increases proportion concentration. The goal this study was examine...