A5067430359- Nonlinear Dynamics and Pattern Formation
- Protein Structure and Dynamics
- Electrochemical Analysis and Applications
- Spectroscopy and Quantum Chemical Studies
- Electron Spin Resonance Studies
- Inorganic and Organometallic Chemistry
- Chemical Reactions and Mechanisms
- Enzyme Structure and Function
- Ionic liquids properties and applications
- DNA and Nucleic Acid Chemistry
- Catalysis and Oxidation Reactions
- Chemical and Physical Studies
- Molecular Junctions and Nanostructures
- Bacterial Genetics and Biotechnology
- Cyclopropane Reaction Mechanisms
- Lipid Membrane Structure and Behavior
- Oxidative Organic Chemistry Reactions
- Fluorine in Organic Chemistry
- Chemical Reaction Mechanisms
- Photochemistry and Electron Transfer Studies
- Advanced biosensing and bioanalysis techniques
- Analytical Chemistry and Chromatography
- RNA and protein synthesis mechanisms
- Supramolecular Self-Assembly in Materials
- Reproductive Biology and Fertility
Comenius University Bratislava
1997-2020
Czech Academy of Sciences
2011-2020
Czech Academy of Sciences, Institute of Microbiology
2020
Czech Academy of Sciences, Global Change Research Institute
2014
Matej Bel University
2008-2013
Cryopreservation is a critical procedure in autologous hematopoietic stem cell transplantation. Dimethyl sulfoxide (DMSO) the cryoprotectant of choice. Optimization cryopreservation protocol past revealed dramatic loss viability associated with reduction DMSO concentration below 2 vol % freezing medium. The cryoprotective mechanism usually ascribed to ability suppress ice formation and reduce adverse effects freeze-concentrated solution. This work proposes an alternative hypothesis...
The kinetics of iodide ions oxidation with hydrogen peroxide in solutions perchloric acid at temperature 60 °C has been studied detail. We have found conditions under which this reaction proceeds oscillatory. Bray−Liebhafsky (BL) oscillatory started by the is described for first time. results support our assumption (Olexová, A.; Mrákavová, M.; Melicherčík, Treindl, L. Collect. Czech. Chem. Commun. 2006, 71, 91−106) that singlet oxygen (1O2) an important intermediate BL sense Noyes−Treindl...
An elegantly simple and probably ancient molecular mechanism of allostery is described for the Escherichia coli arginine repressor ArgR, master feedback regulator transcription in L-arginine metabolism. Molecular dynamics simulations with ArgRC, hexameric domain that binds negative cooperativity, reveal conserved aspartate residues each ligand-binding pocket promote rotational oscillation apoArgRC trimers by engagement release hydrogen-bonded salt bridges. Binding exogenous displaces...
The oxidation of iodine with hydrogen peroxide was studied spectrophotometrically and potentiometrically. At low concentrations HClO 4 , after induction period (IP), the concentration decreases sigmoidally IP decreasing surface area solution interphase. We assume that • OH radicals are produced via iodide H 2 O and, by their subsequent reaction HO formed. By disproportionation, ↔ + 1 very reactive singlet oxygen is can start. described experimental results consistent Noyes-Treindl mechanism.
ADVERTISEMENT RETURN TO ISSUEArticleNEXTA transition-metal oscillator based on the oxidation of manganese(2+) ions by periodatesMilan Melichercik, Gongoryn Sodnomdorz, and Ludovit TreindlCite this: J. Phys. Chem. 1991, 95, 13, 4923–4924Publication Date (Print):June 1, 1991Publication History Published online1 May 2002Published inissue 1 June 1991https://pubs.acs.org/doi/10.1021/j100166a001https://doi.org/10.1021/j100166a001research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNonmonotonous temporal dependence of the concentration ferroin as a reactantMilan Melichercik and Ludovit TreindlCite this: J. Phys. Chem. 1989, 93, 22, 7652–7654Publication Date (Print):November 1, 1989Publication History Published online1 May 2002Published inissue 1 November 1989https://pubs.acs.org/doi/10.1021/j100359a024https://doi.org/10.1021/j100359a024research-articleACS PublicationsRequest reuse permissionsArticle...
The reduction of ferriin ([Fe(phen) 3 ] 3+ , phen = 1,10-phenanthroline) by malonic acid (MA) differs from the Ce(IV) or Mn(III) ions MA in its autocatalytic character and a pregnant influence oxygen, which behaves obviously as catalyst. time dependence ferroin-ferriin redox potential at last stage this reaction has sigmoidal shape, indicates autocatalysis. Under anaerobic conditions, inflection is order several tens minutes, since autocatalysis cannot proceed unless sufficient amount oxygen...
Hexameric arginine repressor, ArgR, is the feedback regulator of bacterial L-arginine regulons, and sensor L-arg that controls transcription genes for its synthesis catabolism. Although ArgR function, as well secondary, tertiary, quaternary structures, essentially same in E. coli B. subtilis, two proteins differ significantly sequence, including residues implicated response to L-arg. Molecular dynamics simulations are used here evaluate behavior intact subtilis with without L-arg, compared...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPermanganate oscillators with keto dicarboxylic acidsMilan Melichercik, Marta Mrakavova, Arpad Nagy, Anna Olexova, and Ludovit TreindlCite this: J. Phys. Chem. 1992, 96, 21, 8367–8368Publication Date (Print):October 1, 1992Publication History Published online1 May 2002Published inissue 1 October 1992https://doi.org/10.1021/j100200a029Request reuse permissionsArticle Views37Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the...
Permanganate chemical oscillators with 1,3-cyclopentanedione, 1,3-cyclohexanedione and dimedone (5,5-dimethyl-1,3-cyclohexanedione) in a CSTR (continuous-flow, stirred tank reactor) are described. The oscillatory systems under study remarkable that the oscillations well developed, but no kinetic bistability has been found. Presumably, may not be pre-requisite for to occur.
The influence of the MoO42- ions on Bray−Liebhafsky (BL) oscillatory reaction is described. affect values parameters BL reaction; first all, they decrease induction period and duration oscillations, but increase average frequency oscillations. A qualitative explanation this based Treindl−Noyes skeleton mechanism reaction. production singlet oxygen (1O2) by disproportionation hydrogen peroxide catalyzed molybdate ions, which obviously quenched physically and/or chemically, may play a role too.
Permanganate chemical oscillators with some keto dicarboxylic acids in the presence of phosphoric acid a continuously stirred tank reactor (CSTR) are described terms phase diagrams [ketomalonic acid] o - k , [oxalacetic and [α-ketoglutaric planes, [H 3 PO 4 ] [MnO temperature- planes. The results show that an optimum degree stabilization Mn(IV) colloid, which may serve as reservoir solvated ions participating elementary reaction steps, is prerequisite for oscillations MnO -keto system. A...