A5013322398- Heat shock proteins research
- Advanced Malware Detection Techniques
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Alzheimer's disease research and treatments
- Circular RNAs in diseases
- Network Security and Intrusion Detection
- Genomics, phytochemicals, and oxidative stress
- Muscle Physiology and Disorders
- Genetic Neurodegenerative Diseases
- Internet Traffic Analysis and Secure E-voting
Netaji Subhas University of Technology
2023
Bose Institute
2016-2018
Alzheimer's disease (AD) is a severe neurodegenerative disorder of the brain that manifests as dementia, disorientation, difficulty in speech, and progressive cognitive behavioral impairment. The emerging therapeutic approach to AD management inhibition β-site APP cleaving enzyme-1 (BACE1), known be one two aspartyl proteases cleave β-amyloid precursor protein (APP). Studies confirmed association high BACE1 activity with proficiency formation β-amyloid-containing neurotic plaques,...
Aggregation of proteins with the expansion polyglutamine tracts in brain underlies progressive genetic neurodegenerative diseases (NDs) like Huntington's disease and spinocerebellar ataxias (SCA). An insensitive cellular proteotoxic stress response to non-native protein oligomers is common such conditions. Indeed, upregulation heat shock factor 1 (HSF1) function its target chaperone expression has shown promising results animal models NDs. Using an HSF1 sensitive cell based reporter...