A5089464658- Heat shock proteins research
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Chromosomal and Genetic Variations
- Physiological and biochemical adaptations
- Neurobiology and Insect Physiology Research
- Insect Resistance and Genetics
- RNA and protein synthesis mechanisms
- Insect and Pesticide Research
- Cancer-related molecular mechanisms research
- Insect and Arachnid Ecology and Behavior
- Viral Infectious Diseases and Gene Expression in Insects
- Phytochemicals and Medicinal Plants
- Genetic Neurodegenerative Diseases
- Invertebrate Immune Response Mechanisms
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Mitochondrial Function and Pathology
- DNA and Nucleic Acid Chemistry
- Genetics, Aging, and Longevity in Model Organisms
- thermodynamics and calorimetric analyses
- Plant Genetic and Mutation Studies
- Genetics, Bioinformatics, and Biomedical Research
- scientometrics and bibliometrics research
- Genetic diversity and population structure
- Plant Reproductive Biology
Banaras Hindu University
2015-2024
Institute of Medical Sciences
2022
Indian Institute of Technology Kanpur
2022
Science and Technology Policy Institute
2016
Massachusetts Institute of Technology
1989
Gujarat University
1974-1977
University of Delhi
1972-1973
University of Calcutta
1969-1970
ABSTRACT Fluorescence RNA:RNA in situ hybridization studies various larval and adult cell types of Drosophila melanogaster showed that the noncoding hsr-omega nuclear (hsrω-n) transcripts were present form many small speckles. These speckles, which we name ‘omega speckles’, distributed interchromatin space close proximity to chromatin. The only chromosomal site where hsrω-n localized was 93D locus or hsrω gene itself. number nucleoplasmic speckles varied different types. Heat shock, inhibits...
Background Ayurveda represents the traditional medicine system of India. Since mechanistic details therapy in terms current biology are not available Ayurvedic literature, modern scientific studies necessary to understand its major concepts and procedures. It is examine effects whole formulations rather than their "active" components as done most studies. Methods We tested two different categories formulations, a Rasayana (Amalaki or AR, an herbal derivative) Bhasma (Rasa-Sindoor RS,...
Thymidine-(3)H labeling patterns on the X (section 1 A to 12 E of Bridges' map) and 2 R 56 F 60 segments in salivary gland chromosomes Drosophila melanogaster have been analyzed male female separately. The observed fit, with a few exceptions, continuous discontinuous sequence. In nuclei similar 2R segment both sexes, number labeled sites is always less than X's. frequency different considerably lower those X's, while very two sexes. rate thymidine-(3)H incorporation (as judged by visual...
Morphology and the rate of RNA synthesis X -chromosome in XX/XO mosaic larval salivary glands Drosophila melanogaster have been examined. For this purpose unstable ring- was utilized to produce XX XO nuclei same pair glands. The width left arm 3rd chromosome (3 L ) measured by them studied upon use [ 3 H]uridine autoradiography such (female) (male) developing a female background (i.e. otherwise genotypically ). In single male is nearly as great that paired two 's nuclei, also case normal ( Y...
Scholarly journals play an important role in maintaining the quality and integrity of research by what they publish.Unethical practices publishing are leading to increased number predatory, dubious low-quality worldwide.It has been reported that percentage articles published predatory is high India.The University Grants Commission (UGC), New Delhi 'approved list journals', which criticized due inclusion many substandard journals.We have developed a protocol with objective criteria for...
Alzheimer's disease (AD) is an age-related neurodegenerative disorder, characterized by progressive loss of cognitive functions and memory. Excessive intake aluminium chloride in drinking water associated with amyloid plaques neurofibrillary tangles the brain, which are hallmark AD. We have evaluated brain energy metabolism (AlCl3) mouse model In addition, effectiveness Rasa Sindoor, a formulation used Indian Ayurvedic medicine, for alleviation symptoms AD was evaluated. Mice were...
The Drosophila hsr omega locus produces one of the largest and most active heat shock puffs, yet it does not encode a protein. Instead, this distinctive set three transcripts, all from same start site. transcript, 1, is limited to nucleus appears have role there. A second nuclear 2, produced by alternative termination contains sequence found in 5' 20-25% 1 (depending on species). cytoplasmic 3, removal 700-bp intron 2. All RNAs are constitutively production enhanced shock. In addition being...
Polyglutamine diseases are a class of inherited neurodegenerative disorders, characterized by expansion CAG trinucleotide repeats translated into elongated glutamine tracts within the mutant proteins. Over-expression non-coding hsrω transcripts has been shown to dominantly enhance polyQ induced cytotoxicity in Drosophila. In present study we demonstrate that RNA interference mediated down regulation hsrω-n is sufficient suppress pathogenesis several Drosophila models human diseases. Loss not...
The complexity in composition and function of the eukaryotic nucleus is achieved through its organization specialized nuclear compartments. Drosophila chromatin remodeling ATPase ISWI plays evolutionarily conserved roles organization. Interestingly, genetically interacts with hsrω gene, encoding multiple non-coding RNAs (ncRNA) essential, among other functions, for assembly omega speckles. nucleoplasmic speckles play important functions RNA metabolism, normal stressed cells, by regulating...
Aggregation of proteins with the expansion polyglutamine tracts in brain underlies progressive genetic neurodegenerative diseases (NDs) like Huntington's disease and spinocerebellar ataxias (SCA). An insensitive cellular proteotoxic stress response to non-native protein oligomers is common such conditions. Indeed, upregulation heat shock factor 1 (HSF1) function its target chaperone expression has shown promising results animal models NDs. Using an HSF1 sensitive cell based reporter...