A5078711098- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Phytochemical compounds biological activities
- Catalytic Cross-Coupling Reactions
- Bioactive Compounds in Plants
- Natural product bioactivities and synthesis
- Phytochemicals and Antioxidant Activities
- Synthetic Organic Chemistry Methods
- Metal complexes synthesis and properties
- Phytochemistry and Biological Activities
- Natural Antidiabetic Agents Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Crystallography and molecular interactions
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Bioactive Compounds
- Synthesis and biological activity
- Natural Compound Pharmacology Studies
- Crystal structures of chemical compounds
- Bioactive Compounds and Antitumor Agents
- Angiogenesis and VEGF in Cancer
- Bioactive natural compounds
- Medicinal Plants and Neuroprotection
- Ginger and Zingiberaceae research
- Pomegranate: compositions and health benefits
Australian National University
2017-2024
Hasanuddin University
2024
Australian Cancer Research Foundation
2017-2024
Hazara University
2024
Sultan Abdul Halim Hospital
2021-2024
Quest International University Perak
2016-2022
The University of Queensland
2011-2022
Universiti Sains Malaysia
2012-2021
Sriwijaya University
2021
University of Dhaka
2019
The present study reports a bioassay-guided isolation of β-caryophyllene from the essential oil Aquilaria crassna. structure was confirmed using FT-IR, NMR and MS. antimicrobial effect examined human pathogenic bacterial fungal strains. Its anti-oxidant properties were evaluated by DPPH FRAP scavenging assays. cytotoxicity tested against seven cancer cell lines. corresponding selectivity index determined testing its on normal cells. effects studied series in vitro antitumor-promoting assays...
O. stamineus is a medicinal herb with remarkable pharmacological properties. However, poor solubility of the active principles limits its value. This study sought to prepare nano liposomes OS ethanolic extract in unpurified soybean phospholipids order improve and permeability. were prepared by conventional film method, characterized for solubility, entrapment efficiency, Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), particle size zeta potential,...
Abstract Background Xanthones are a group of oxygen-containing heterocyclic compounds with remarkable pharmacological effects such as anti-cancer, antioxidant, anti-inflammatory, and antimicrobial activities. Methods A xanthones extract (81% α-mangostin 16% γ-mangostin), was prepared by crystallization toluene G. mangostana fruit rinds analyzed LC-MS. Anti-colon cancer effect investigated on HCT 116 human colorectal carcinoma cells including cytotoxicity, apoptosis, anti-tumorigenicity, cell...
Toinvestigate the anti-angiogenic activity and antioxidant properties of Myristica fragrans (M. fragrans) (nutmeg) Morinda citrifolia citrifolia)(mengkudu) oils. The nutmeg megkudu essential oils were obtained by steam distillation. activities both determined beta-carotene/linoleic acid bleaching assay reducing power while was investigated using rat aortic ring various concentrations. results showed that oil has higher than mengkudu oil. effectively inhibited oxidation linoleic with...
This study investigated the antioxidant and in vitro cytotoxic effects of essential oils (EOs) obtained from fruits Illicium verum. The solvent extraction method was used to extract fruits. Antioxidant properties were assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) ferric reducing power (FRAP) assays followed by estimation total phenolic flavonoid contents gas chromatography–mass spectrometry (GC-MS) analysis....
Consumption of medicinal plants to overcome diseases is traditionally belongs the characteristics most cultures on this earth. Sudan has been a host and cradle various ancient civilizations developed vast knowledge traditional plants. The present study was undertaken evaluate antioxidant, antiangiogenic cytotoxic activities six Sudanese which have used treat neoplasia. Further biological were correlated with phytochemical contents plant extracts. Different parts subjected sequential...
OBJECTIVE:The present study aimed to investigate the mechanisms underlying anti-inflammatory and antiangiogenic effects of ethyl-p-methoxycinnamate isolated from Kaempferia galanga.METHODS: The were assessed using cotton pellet granuloma assay in rats, whereby levels interleukin-1 tumor necrosis factor-a measured animals' blood.In addition, interleukin, factor, nitric oxide vitro human macrophage cell line (U937).The analgesic by tail flick rats.The anti-angiogenic evaluated first rat aortic...
Desert truffles are seasonal and important edible fungi that grow wild in many countries around the world. Truffles natural food sources have significant compositions. In this work, antioxidant, chemical composition, anticancer, antiangiogenesis properties of Terfezia claveryi truffle were investigated. Solvent extractions T. evaluated for antioxidant activities using (DPPH, FRAP ABTS methods). The extracts cytotoxicity on cancer cell lines (HT29, MCF-7, PC3 U-87 MG) was determined by MTT...
Polyethylene glycol (PEG) coated Poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) for cancer treatment are biocompatible, nonimmunogenic and accumulate in tumour sites due to the enhanced permeability retention (EPR). Doxorubicin (DOX) is a potent but cardiotoxic anticancer agent. Hyaluronic (HA) occurs naturally extra-cellar matrix binds CD44 receptors which overexpressed metastasis, proven be characteristic of stem cells responsible multidrug resistance. In this study, an athymic...
In this study the chemical composition, antioxidant activities and cytotoxic effect of essential oils Myristica fragrans (nutmeg) Morinda citrifolia (mengkudu) were determined.Thirty-eight compounds in nutmeg oil six mengkudu identified by gas chromatography–mass spectrometry. The free radical scavenging activity was superior that oil. MTT assay on human colorectal carcinoma (HCT-116) breast (MCF-7) cell lines showed IC₅₀ values 78.61 66.45 µg mL⁻¹, respectively. exhibited 91.46 78.15 mL⁻¹...
Since the first successful synthesis of Ag(I)-N-heterocyclic carbene complex in 1993, this class compounds has been extensively used for transmetallation reactions where direct using other metal ions was either difficult or impossible. Initially, silver(I)-NHC complexes were tested their catalytic potential but could not get fame because lower compare to competent field; however, these proved have vital antimicrobial activities. These encouraging biomedical applications further convinced...
Unsymmetrically substituted sterically tuned Pd(ii)–NHC complexes of the general formula [PdCl2(NHC)2] (NHC = 1-allyl-3-methylimidazolin-2-ylidene, 7; 1-allyl-3-butylimidazol-2-ylidene, 8; 1-benzyl-3-butyl imidazolin-2-ylidene, 9) were prepared through transmetallation from their corresponding Ag(i)–NHC complexes. The Pd structurally characterized by different spectroscopic and X-ray diffraction methods. Complexes 7 9 adopted a trans–anti arrangement NHC ligands, whereas complex 8 cis–syn...
Purpose. To determine the neuroprotective properties of a latanoprost acid derivative (ACS67) that donates gas hydrogen sulfide (H(2)S). Methods. Ischemia to rat retina was induced by elevation intraocular pressure. Electroretinograms (ERGs) were recorded and retinas analyzed 2 days later immunohistochemistry, Western blot analysis, RT-PCR. Hydrogen peroxide (H(2)O(2)) used impose an insult on RGC-5 cells in culture. The nature cultures quantified resazurin-reduction assay procedure,...