A5009332619- Computational Drug Discovery Methods
- Synthesis and biological activity
- Cancer-related molecular mechanisms research
- vaccines and immunoinformatics approaches
- RNA Research and Splicing
- Transgenic Plants and Applications
- Circular RNAs in diseases
- Bioactive Compounds and Antitumor Agents
- MicroRNA in disease regulation
- Biochemical and Molecular Research
- Pharmacological Effects of Natural Compounds
- Hemoglobinopathies and Related Disorders
- PI3K/AKT/mTOR signaling in cancer
- Poxvirus research and outbreaks
- Bioinformatics and Genomic Networks
- Antibiotics Pharmacokinetics and Efficacy
- Viral-associated cancers and disorders
- Metabolism, Diabetes, and Cancer
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Phytochemicals and Antioxidant Activities
- Essential Oils and Antimicrobial Activity
- Antibiotic Resistance in Bacteria
- Machine Learning in Bioinformatics
- Cancer therapeutics and mechanisms
Shaqra University
2022-2024
Jazan University
2017
Introduction Monkeypox is a zoonotic disease caused by brick-shaped enveloped monkeypox (Mpox) virus that belongs to the family of ancient viruses known as Poxviridae. Subsequently, have been reported in various countries. The transmitted respiratory droplets, skin lesions, and infected body fluids. patients experience fluid-filled blisters, maculopapular rash, myalgia, fever. Due lack effective drugs or vaccines, there need identify most potent reduce spread monkeypox. current study aimed...
Malaria is a mosquito-borne infectious disease that caused by the
Vibrio vulnificus is a rod shape, Gram-negative bacterium that causes sepsis (with greater than 50% mortality rate), necrotizing fasciitis, gastroenteritis, skin, and soft tissue infection, wound peritonitis, meningitis, pneumonia, keratitis, arthritis. Based on pathogenicity V. categorized into three biotypes. Type 1 type 3 cause diseases in humans while biotype 2 eel fish. Due to indiscriminate use of antibiotics has developed resistance many so curing dramatically challenge. resistant...
The signal transducer and activator of transcription 3 (STAT3) plays a fundamental role in the growth regulation cellular life. Activation over-expression STAT3 have been implicated many cancers including solid blood tumors other diseases such as liver fibrosis rheumatoid arthritis. Therefore, inhibitors are be coming growing interesting area pharmacological research. Consequently, aim this study is to design novel STAT3-SH3 computationally for reduction fibrosis. Herein, we performed...
Abstract Zika virus is an infectious virus, that belongs to Flaviviridae family, which transferred humans through mosquito vectors and severely threatens human health; but, apart from available resources, no effective secure vaccine present against prevent such infections. In current study, we employed structural vaccinology approach design epitope-based biocompatible, might trigger adaptive innate immune response by using computational approaches. We first retrieved the protein sequence...
The NOD-Like Receptor Protein-3 (NLRP3) inflammasome is a key therapeutic target for the treatment of epilepsy and has been reported to regulate inflammation in several neurological diseases. In this study, machine learning-based virtual screening strategy investigated candidate active compounds that inhibit NLRP3 inflammasome. As potential accurately predict protein-ligand binding reduce false positives outcomes compared traditional screening. Briefly, classification models were created...
Lung cancer is the leading cause of mortality from worldwide. adenocarcinoma (LUAD) a type non-small cell lung (NSCLC) with highest prevalence. Kinesins class motor proteins are shown to be involved in carcinogenesis. We conducted expression, stage plot and survival analyses on kinesin superfamily (KIF) scrutinized key prognostic kinesins. Genomic alterations these kinesins were studied thereafter via cBioPortal. A protein-protein interaction network (PPIN) selected 50 closest altering genes...
Lung cancer is a pervasive and challenging disease with limited treatment options, global health challenges often present complex molecular profiles necessitating the exploration of innovative therapeutic strategies. Single-target drugs have shown success due to heterogeneity this disease. Multitargeted drug designing imperative combat complexity by simultaneously targeting multiple target proteins pathways, which can enhance efficacy overcome resistance addressing dynamic nature stopping...
Diabetes affects people of all ages, regardless gender and background. To date, there is no evidence for the effect sakuranetin against streptozotocin (STZ)-induced diabetes paradigm. The research was directed to evaluate antidiabetic activity in STZ model invoking diabetes-induced disease (I.P. 60 mg/kg) induce type 2 experimental rats. Recent pursued regulate anti-diabetic ability at both 10 20 mg/kg STZ-induced Furthermore, molecular docking implemented requisite attraction inflammatory...
The epigenetic regulation of lncRNA TUG1 has garnered significant attention in the context diabetes and its associated disorders. TUG1′s multifaceted roles gene expression modulation, cellular differentiation, it plays a major role growth issues that are related to due pathological processes. In diabetes, aberrant modifications can lead dysregulation expression, contributing disrupted insulin signaling, impaired glucose metabolism, beta-cell dysfunction. Moreover, been reported contributes...
Introduction. The risk of developing transfusion-related complications, especially alloimmunization, is an ongoing concern for transfusion-dependent patients. It important to determine the rate alloimmunization and autoimmunization in Al-Ahsa Region, Saudi Arabia, where sickle cell disease (SCD) thalassemia incidence rates are highest Arabia. Methods. A cross-sectional study was conducted review transfusion history patients with SCD at King Fahad Hospital (KFH) Al-Ahsa, 364 were included...
The treatment and outcome of respiratory virus infections differ. SARS-CoV-2, as well other viruses such influenza (A B) syncytial (RSV), require simultaneous, cost-effective, rapid differential detection. We used a gold standard five-target single-step RT-PCR to detect viruses, RSV, this method can be extended subtypes. As result, is ideal for differentiating viruses. 5' nuclease activity Taq DNA polymerase in the real-time reverse transcription PCR assay. man fast viral 1-step enzyme 4×...