A5015081947- Cancer-related molecular mechanisms research
- Advancements in Transdermal Drug Delivery
- Computational Drug Discovery Methods
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA Research and Splicing
- RNA modifications and cancer
- Advanced Drug Delivery Systems
- Dermatology and Skin Diseases
- Peripheral Neuropathies and Disorders
- Antibiotics Pharmacokinetics and Efficacy
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Herpesvirus Infections and Treatments
- Cutaneous lymphoproliferative disorders research
- Antioxidant Activity and Oxidative Stress
- Viral-associated cancers and disorders
- Graphene and Nanomaterials Applications
- Nerve injury and regeneration
- Pesticide Residue Analysis and Safety
- Diabetic Foot Ulcer Assessment and Management
- vaccines and immunoinformatics approaches
- Wound Healing and Treatments
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
Shaqra University
2022-2024
Ferghana Polytechnical Institute
2024
Diabetes affects people of all ages, regardless gender and background. To date, there is no evidence for the effect sakuranetin against streptozotocin (STZ)-induced diabetes paradigm. The research was directed to evaluate antidiabetic activity in STZ model invoking diabetes-induced disease (I.P. 60 mg/kg) induce type 2 experimental rats. Recent pursued regulate anti-diabetic ability at both 10 20 mg/kg STZ-induced Furthermore, molecular docking implemented requisite attraction inflammatory...
Treating neurological illnesses is challenging because the blood-brain barrier hinders therapeutic medications from reaching brain. Recent advances in polymeric nanocarriers (PNCs), which improve medication permeability across barrier, may influence therapy strategies for diseases. PNCs have several ways to deliver nervous system. This review article provides a summary of parts and manufacturing methods involved making PNCs. Additionally, it highlights elements that result having enhanced...
Abstract Background Atopic dermatitis is an abnormal skin condition that impacts a significant number of people in the US, with estimated 9.6 million children and 16.5 adults being affected by it. The study aimed to characterize optimize clove oil-based nanomicelles for possible topical use bacterial infection-led atopic dermatitis. Clove oil-loaded were produced carefully analyzed vesicle diameter, polydispersity index (PDI), zeta potential, morphological attributes, entrapment efficiency,...
Programmed cell death ligand 1 (PD-L1) is a crucial target for cancer therapy. Here, an in silico study investigates PD-L1 to inhibit its interaction with PD1, thereby promoting immune response eliminate cells. The employed machine learning (ML) -based QSAR detect PDL1 inhibitors. Morgan's fingerprint docking score showed 0.83 correlation the experimental IC50, enabling screening of 3200 natural compounds. top three compounds, considered 2819, 2821 and 3188, were selected from ML-based...
One of the viral diseases that affect millions people around world, particularly in developing countries, is Japanese encephalitis (JE). In this study, conserved protein virus, is, non-structural 5 (NS5), was used as a target for and compound library 749 antiviral molecules screened against NS5. The current study employed machine learning-based virtual screening combined with molecular docking. Here, three hits (24360, 123519051 213039) had lower binding energies (< −8 kcal/mol) than...
In the present study, a gradient reversed-phase high-performance liquid chromatography (RP-HPLC) method has been designed and validated to quantify Ornidazole (OZ) in marketed formulation (oral gel) with application of QbD. The proposed HPLC utilizes an RP C18 column (4.6 x 250 mm, 5 μm). mobile phase contained grade Solvent A (water) B (acetonitrile) ran at flow rate 1 mL/min mode. linearity was plotted OZ range 1–12 μg/mL correlation coefficient found be 0.9998. limit quantification, as...
Tuberculosis (TB) is a global health challenge; therefore, there an urgent requirement to develop novel and more effective anti-TB therapeutic. This study targeted the isocitrate lyase (ICL) protein due its pivotal role in pathogenicity of
In the present study, formation of a heterodimer involving both epidermal growth factor receptor (EGFR) and human 2 (HER2) has been explored as potential therapeutic mechanism to inhibit progression breast cancer. Virtual screening using molecular docking resulted in three hit compounds (ZINC08382411, ZINC08382438, ZINC08382292) with minimum binding scores commonly receptors. Further, MD simulation analysis these complexes illustrated high stability EGFR HER2. RMSD showed that ZINC08382411...
The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), has claimed a global health crisis of unpredictable amount. Due to its high mortality, many COVID-19 vaccines are being developed, approved, and manufactured rapidly. However, some serious neurological adverse events (AEs) were reported after the application them. This review was conducted collect discuss published data about side effects SARS-CoV-2 in order discover type, frequency,...
Background: SARS-CoV-2 emerged in late 2019 and caused COVID-19. Patients treated with Zyesami were found to have a 3-fold decrease respiratory failure improved clinical outcomes. It was reported that inhibits RNA replication of SARS-CoV-2, including several non-structural proteins essential viral replication. is distinctive virus requires nsp10 nsp16 for its methyltransferases activity which crucial stability protein synthesis. Objective: We aimed the silico determination inhibitory...