A5018064188- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Chromatography
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacological Effects and Assays
- Synthesis and biological activity
- Computational Drug Discovery Methods
- Pesticide Residue Analysis and Safety
- Advanced Photocatalysis Techniques
- Analytical Chemistry and Sensors
- Antiplatelet Therapy and Cardiovascular Diseases
- Click Chemistry and Applications
- Systemic Lupus Erythematosus Research
- Herpesvirus Infections and Treatments
- Synthesis and Characterization of Heterocyclic Compounds
- Carcinogens and Genotoxicity Assessment
- Advanced Chemical Sensor Technologies
- Gas Sensing Nanomaterials and Sensors
- Drug Solubulity and Delivery Systems
- RNA Interference and Gene Delivery
- Pharmacological Effects of Natural Compounds
- Phytochemistry and biological activity of medicinal plants
- Nanoparticle-Based Drug Delivery
- Phenothiazines and Benzothiazines Synthesis and Activities
- Anesthesia and Sedative Agents
- TiO2 Photocatalysis and Solar Cells
JSS Academy of Higher Education and Research
2016-2025
First Affiliated Hospital of Zhengzhou University
2022
Abstract: Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by social communication deficits and repetitive behaviors. Emerging evidence highlights the significant role of glial cells, particularly astrocytes microglia, in pathophysiology ASD. Glial cells are crucial for maintaining homeostasis, modulating synaptic function, responding to neural injury. Dysregulation cell functions, including altered cytokine production, impaired pruning, disrupted...
Several chemical studies described the physiological efficacy of 1,4- dihydropyridines (DHPs). DHPs bind to specific sites on α1 subunit L-type calcium channels, where they demonstrate a more pronounced inhibition Ca2+ influx in vascular smooth muscle compared myocardial tissue. This selective is basis for their preferential vasodilatory action peripheral and coronary arteries, characteristic that underlies therapeutic utility managing hypertension angina. Among vascular-selective DHPs,...
Background: Rh4 (a compound derived from ginsenoside) has excellent anti-tumor property. It been documented that an abnormally elevated level of Notch3 expression is linked to poor prognosis gastric cancer (GC). Currently, the function in GC malignant progression still unclear, and manner which regulates remains undefined. Methods: The cells was determined utilizing qRT-PCR western blot. relationship between patient overall survival forecasted by Kaplan-Meier Plotter database. impacts on...
Artificial Intelligence (AI) is mainly utilized to measure stress, anxiety, and overall mental well-being, but it still under evaluation. This review aims address some of the inadequacies current healthcare practices through utilization AI technology for monitoring, diagnosing, transforming health conditions. The application machine learning algorithms natural language processing techniques assess speech, physiological indicators, behavioral patterns essence approach. These AI-based enable...
The main purpose of the study is to establish Bioanalytical method development for enantiomeric divergence and Stereoselective Pharmacokinetic activity 1-(4-bromophenyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide(B06). Isoquinoline derivatives have various activities like anticancer, anti-convulsant etc. proposed project mainly focused on anti-cancer synthesized B-06 compound as it shown very good cytotoxicity MBA-MD-231 MCF-7 cell lines by using SRB assay. specified was...
Various 7-chloro-6-fluoro-2-arylidenylaminobenzo(1,3)thiazole (2a-h) have been synthesized by the condensation of 7-chloro-6-fluoro-2-aminobenzo(1,3)thiazole (1) with different aromatic aldehydes. The Schiff's bases on reaction acetyl chloride, chloroacetyl chloride and phenyl yielded 1-(7-chloro-6-fluorobenzothiazol-2-yl)-3,4-substituted-aryl-azetidin-2-ones (3a-x). Similarly, cyclization base thioglycolic acid furnished...
Cerebral malaria (CM), a severe neurological pathology caused by Plasmodium falciparum infection, poses significant global health threat and has high mortality rate. Conventional therapeutics cannot cross the blood-brain barrier (BBB) efficiently. Therefore, finding effective treatments remains challenging. The novelty of treatment proposed in this study lies feasibility intranasal (IN) delivery nanostructured lipid carrier system (NLC) combining microRNA (miRNA) artemether (ARM) to enhance...
In the present study, a series of coumarin derivatives were designed, synthesized and evaluated for their antioxidant cytotoxic properties.
The ability to address the cell cycle in cancer therapy brings up new medication development possibilities. Cyclin-dependent kinases are a group of proteins that control progression cycle. CDK/cyclin complexes activated when specific CDK sites phosphorylated. Because their non-selectivity and severe toxicity, most first-generation inhibitors (also known as pan-CDK inhibitors) have not been authorized for clinical usage. Despite this, significant progress has made allowing be employed...
Purpose: To develop a simple, sensitive and specific liquid chromatographic method with PDA detection for the simultaneous estimation of ciprofloxacin tinidazole in tablet dosage form.Methods: Separation was achieved an Agilent XDB C18, 250 × 4.60 mm 5 μ column, low pressure gradient mode ambient temperature mobile phase comprising acetonitrile water containing 0.1 % orthophosphoric (20:80). The flow rate 1 ml/min eluent monitored spectrophotometrically at 316 nm.Results: selected conditions...
Background:: Platinum derivatives are chemotherapeutic agents preferred for the treatment of cancers including breast cancer. Oxaliplatin is an anticancer drug that in phase II studies to treat metastatic However, its usage constrained by chemoresistance and dose-related side effects. Objective:: The objective this study examine combinatorial efficacy brusatol, Nrf2 blocker, with oxaliplatin (a proven FN3K blocker our study) mitigating cancer growth vitro. Methods:: We performed cytotoxicity...
Abstract: Previous studies described that asthma patients who received corticosteroid therapy have been constrained by the resistance subsequently fostered to severe refractory asthma. In this review, we discussed implications of TSLP, RXR, role STAT5-activating cytokines, and IL-33/NH-cell signaling pathways, recent clinical evidence on TSLP blockers in steroid-resistant We searched several public databases such as Pubmed, Scopus, Relemed obtained information pertinent blockers, IL-33....
Treating neurological illnesses is challenging because the blood-brain barrier hinders therapeutic medications from reaching brain. Recent advances in polymeric nanocarriers (PNCs), which improve medication permeability across barrier, may influence therapy strategies for diseases. PNCs have several ways to deliver nervous system. This review article provides a summary of parts and manufacturing methods involved making PNCs. Additionally, it highlights elements that result having enhanced...
Fructosamine-3-kinase (FN3K) is involved in the deglycation of Nrf2, a significant regulator oxidative stress cancer cells. However, intricate functional aspects FN3K and Nrf2 breast cancers have not been explored vividly. The objectives this study are to design human protein using homology modeling followed by screening several anticancer molecules examining their efficacy modulate activity, Nrf2-mediated antioxidant signalling. Methods pertinent modeling, virtual screening, molecular...