A5093643755- Viral Infections and Outbreaks Research
- Enzyme Catalysis and Immobilization
- Listeria monocytogenes in Food Safety
- Natural Antidiabetic Agents Studies
- Synthesis and Biological Evaluation
- Bacillus and Francisella bacterial research
- Atherosclerosis and Cardiovascular Diseases
- Aquaculture disease management and microbiota
- Identification and Quantification in Food
- Peptidase Inhibition and Analysis
- Computational Drug Discovery Methods
- SARS-CoV-2 and COVID-19 Research
- Synthesis and biological activity
- Drug Transport and Resistance Mechanisms
- Heat shock proteins research
- Enzyme Structure and Function
- Diet, Metabolism, and Disease
- vaccines and immunoinformatics approaches
- Probiotics and Fermented Foods
Shaqra University
2024-2025
, a gram-negative coccobacillus bacterium, can cause various infections in humans, including septic arthritis, diarrhea (traveler's diarrhea), gastroenteritis, skin and wound infections, meningitis, fulminating septicemia, enterocolitis, peritonitis, endocarditis. It frequently occurs aquatic environments readily contacts leading to high infection rates. This bacterium has exhibited resistance numerous commercial antibiotics, no vaccine yet been developed. Aiming combat the alarmingly rate,...
The Marburg virus (MBV), a deadly pathogen, poses serious threat to world health due the lack of effective treatments, calling for an immediate search targeted and efficient treatments. In this study, we focused on compounds originating from marine fungi in order identify possible inhibitory against (MBV) VP35-RNA binding domain (VP35-RBD) using computational approach. We started with virtual screening procedure Lipinski filter as guide. Based their docking scores, 42 potential candidates...
Diabetes, affecting over 10.5% of the global population, leads to severe health complications and economic burdens, highlighting urgent need for effective therapeutic approaches. Current treatments are often insufficient, prompting exploration novel agents delivery mechanisms. This study addresses this gap by investigating roles L-arginine (identified as a target drug candidate through network pharmacology) in diabetes management, while also evaluating lipid nanocarriers synthesized from...
Cervical cancer presents a significant healthcare challenge due to recurrent disease and drug resistance, highlighting the urgent need for novel therapeutic strategies. Network pharmacology facilitates repurposing by elucidating multi-target mechanisms of action. Adefovir, an acyclic nucleotide analog, has shown promising potential in cervical treatment, particularly HeLa cells. In vitro studies have demonstrated that adefovir inhibits cell proliferation enhancing apoptosis while maintaining...
Neurosyphilis, a severe neurological complication of syphilitic infection caused by the gram-negative spirochete Treponema pallidum poses significant challenges in treatment due to its irregular physiology and lack efficacy present therapeutic strategies. Here, we report new approach developing drug that targets enzyme phosphoglycerate kinase (PGK), an essential component T. glycolytic pathway. Therefore, ligand was designed involving common neuroprotectant elements reported from literature...
Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, emphasizing the need for improved prognostic biomarkers. Recent studies have identified mRNA-modifying METTL3 oncogene as potential biomarker in CRC progression. This study aimed to investigate expression patterns CRC, assess its association with clinical outcomes, identify interacting proteins and biological pathways, explore correlation immune cell infiltration. Comprehensive analyses were conducted using...
Programmed cell death ligand 1 (PD-L1) is a crucial target for cancer therapy. Here, an in silico study investigates PD-L1 to inhibit its interaction with PD1, thereby promoting immune response eliminate cells. The employed machine learning (ML) -based QSAR detect PDL1 inhibitors. Morgan's fingerprint docking score showed 0.83 correlation the experimental IC50, enabling screening of 3200 natural compounds. top three compounds, considered 2819, 2821 and 3188, were selected from ML-based...
The bacterial cell wall, being a vital component for viability, is regarded as promising drug target. L, D-Transpeptidase YcbB enzyme has been implicated significant role in wall polymers cross linking during typhoid toxin release, β-lactam resistance and outer membrane defect rescue. These observations have recorded different pathogens such Salmonella Typhimurium, Citrobacter rodentium, typhi. In this work, we shown structure based virtual screening of diverse natural synthetic libraries...