A5051428996- Natural Antidiabetic Agents Studies
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Retinal Diseases and Treatments
- SARS-CoV-2 and COVID-19 Research
- Ultrasound in Clinical Applications
- Nutrition and Health in Aging
- PARP inhibition in cancer therapy
- Global Cancer Incidence and Screening
- Cerebrovascular and genetic disorders
- Metabolism and Genetic Disorders
- Folate and B Vitamins Research
- Nanoparticles: synthesis and applications
- Botanical Studies and Applications
- Antioxidants, Aging, Portulaca oleracea
- Tea Polyphenols and Effects
- Ion Transport and Channel Regulation
- Retinal Imaging and Analysis
- Medicinal Plants and Bioactive Compounds
- Curcumin's Biomedical Applications
- Liver Disease Diagnosis and Treatment
- Influenza Virus Research Studies
- HIV-related health complications and treatments
- Hemostasis and retained surgical items
- Glaucoma and retinal disorders
King Saud University
2017-2024
University of Sheffield
2013-2022
King Saud Medical City
2017
Dexamethasone (Dex) is a synthetic glucocorticoid (GC) drug commonly used clinically for the treatment of several inflammatory and immune-mediated diseases. Despite its broad range indications, long-term use Dex known to be associated with specific abnormalities in tissues organs. In this study, metabolomic effects on five different organs induced by chronic administration Sprague-Dawley rat model were investigated using chemical isotope labeling liquid chromatography-mass spectrometry (CIL...
Objectives This cross-sectional analytical study aims to evaluate medical students' awareness and satisfaction regarding the utilization of simulation-based learning (SBL) as a method for clinical teaching at King Saud University (KSU) over past 12 months. It seeks understand how such methods enhance self-satisfaction skills, facilitate application learned knowledge, assess role instructors in providing ample practice opportunities skills laboratory. Furthermore, levels students both...
Background: Pneumonia is a ubiquitous health condition with severe outcomes. The advancement of ultrasonography techniques allows its application in evaluating pulmonary diseases, providing safer and accessible bedside therapeutic decisions compared to chest X-ray computed tomography (CT) scan. Because aforementioned benefits, we aimed confirm the diagnostic accuracy lung ultrasound (LUS) for pneumonia adults. Methods: A systematic literature search was performed Medline, Cochrane Crossref,...
The binding of vascular endothelial growth factor (VEGF) to VEGF receptor-2 (VEGFR-2) on the surface cells stimulates many steps in angiogenic pathway. Inhibition this interaction is proving value moderating neovascularization accompanying age-related macular degeneration and treatment cancer. Tissue inhibitor metalloproteinases-3 (TIMP-3) has been shown be a natural VEGFR-2 specific antagonist—an activity that independent its ability inhibit metalloproteinases. In investigation we localize...
Dexamethasone is a synthetic glucocorticoid medication vastly used to treat abnormal immune responses and inflammation. Although the well-established in medical community, prolonged treatment with high dosages of dexamethasone may lead severe adverse effects through mechanisms that are not yet well-known. Lipids large class hydrophobic molecules involved energy storage, signaling, modulation gene expression, membranes. Hence, untargeted lipidomics help unravel biochemical alterations...
Abstract Dithiocarbamate derivatives possess diverse biological activities. This work further expands their activity profile by identifying seven benzylamine‐containing dithiocarbamate with piperazine and piperidine substitutions at the main moiety, five piperazine‐containing dithiocarbamates various moiety as new inhibitors of α‐glucosidase. Compounds bearing benzylamine exhibited more potent inhibition enzyme than derivatives. Majority compounds non‐competitively inhibited α‐glucosidase...
Very-long-chain acyl-coenzyme A dehydrogenase (VLCAD) is a coenzyme encoded by ACADVL that converts very-long-chain fatty acids into energy. This process disrupted c.65C>A; p.Ser22* mutation. To clarify mechanisms which this mutation leads to VLCAD deficiency, we evaluated differences in molecular and cellular functions between mesenchymal stem cells with normal mutant VLCAD. Saudi Arabia have high incidence of form Stem were isolated from skin two patients. Metabolic activity proliferation...
Objectives Meningitis is a medical emergency with permanent disabilities and high mortality worldwide. We aimed to determine causative microorganisms potential markers for differentiation between bacterial viral meningitis. Methodology Adult patients acute meningitis were subjected lumber puncture. Cerebrospinal fluid (CSF) identified using Real-time PCR. PCT CRP levels, peripheral CSF-leucocyte count, CSF-protein CSF-glucose levels assessed. Results Out of 80 patients, infectious was...
Cystic renal disease (CRD) comprises a heterogeneous group of genetic and acquired disorders. The cystic lesions are detected through imaging, either incidentally or after symptoms develop, due to an underlying process. In this study, we aim study the metabolomic profiles CRD patients for potential disease-specific biomarkers using unlabeled labeled metabolomics low high-resolution mass spectrometry (MS), respectively. Dried-blood spot (DBS) serum samples, collected from healthy controls,...
To study the knowledge, attitude and practice level among young Saudi adults regarding osteoporosis.A cross-sectional was done in Riyadh Saudis, within age group (17-30 years old), with sample size (663). A validated questionnaire distributed paper electronic forms. The had five parts: first part demographic variables, second source of participant knowledge about disease, third assessed osteoporosis, fourth osteoporosis attitudes, fifth for prevention osteoporosis. collected data analysed by...
To assess awareness of diabetic retinopathy (DR) for Saudis with diabetes mellitus (DM) type 2 in Riyadh City.A cross-sectional study that used self-administered questionnaires conducted primary healthcare centers City between October and December 2019.There were 267 Saudi participants visiting clinics. (52.4%) aged 40 years or above at time diagnosis diabetes. (73%) had least 5 years. Most the have a good blood glucose control they do home measurements. In regard to DR, (64.4%) no...
To estimate the awareness level of Saudi adults about risk factors and warning signs cancer observe association different determinants with Knowledge in Riyadh city.A cross-sectional study carried out on 390 Saudis outpatient clinics King Khalid University Hospital (KKUH), Riyadh. Data was collected using a validated Arabic questionnaire. analyzed SPSS software.The overall participants limited, as mean score knowledge 49.2%. Most correctly answered questions were general not or warnings...
Irritable bowel syndrome is prevalent in the general population. This study investigates association between dietary intake and irritable medical college students at King Saud University besides its prevalence.This an analytical cross-sectional of 426 (271 males 155 females, age 21.21 ± 1.58 years) from 5 academic levels Medical College. A self-reported questionnaire for Rome IV criteria was completed by each participant. They also filled out a food frequency to assess their nutritional...
Hepatitis C is a common viral infection worldwide. Finding the most effective diagnostic methods with low cost always needed for laboratory improvement. In this study, we evaluated performance of quantitative chemiluminescent hepatitis virus core antigen (HCV cAg) test by comparing it HCV confirmatory antibody line immunoblot assay Ab-LIA) as well quantitate reverse transcription-polymerase chain reaction (qRT-PCR) test.A total 394 samples were enrolled in retrospective study. Of these, 225...
Abstract: Background: Hyperuricemia and inflammation are associated with the etiology pathogenesis of several metabolic diseases. Controlling elevated levels uric acid can be a potential therapeutic option for Aim: The current study examined anti-inflammatory anti-hyperuricemic properties Ficus benghalensis bark extract in vitro using murine macrophage RAW 246.7 cells. Materials Methods: Hydroalcoholic extracts were obtained. Cytotoxicity cell viability test was evaluated by MTT Trypan blue...
Background and Objectives: Folic acid (FA) is a necessary ingredient for numerous bodily activities including pregnancy. Because of this, women should have knowledge awareness the health benefits FA supplementation. Thus, we aimed to investigate level on importance determine associated factors among female college students at King Saud University in Riyadh, Saudi Arabia. Material Methods: We conducted cross-sectional study using questionnaire between January 2020 February 2021 aged 17 26...
Patients who need to be readmitted the hospital because of complications from infections or require long-term care and rehabilitation face substantial financial hardships. To ensure safety patients undergoing surgery, it is crucial implement measures that prevent wound before after procedure. Antibacterial dressings are essential during surgical procedures. There various types antibacterial available on market, such as silver-based dressings, hydrocolloid polyhexamethylene biguanide,...