A5033836246- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Pituitary Gland Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Advanced biosensing and bioanalysis techniques
- Mitochondrial Function and Pathology
- Immune Cell Function and Interaction
- Ion Transport and Channel Regulation
- Trace Elements in Health
- Biochemical and Molecular Research
- Growth Hormone and Insulin-like Growth Factors
- Metabolism and Genetic Disorders
- Erythrocyte Function and Pathophysiology
- Assistive Technology in Communication and Mobility
- PARP inhibition in cancer therapy
- Adipose Tissue and Metabolism
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Hormonal Regulation and Hypertension
- DNA Repair Mechanisms
- Adrenal Hormones and Disorders
- Cancer, Lipids, and Metabolism
- Biochemical effects in animals
Université du Québec à Montréal
2021-2024
Universiti Putra Malaysia
2023
King Faisal Specialist Hospital & Research Centre
2018-2020
Jordan University of Science and Technology
2018
Dexamethasone (Dex) is a synthetic glucocorticoid that has anti-inflammatory and immunosuppressant effects used in several conditions such as asthma severe allergy. Patients receiving Dex, either at high dose or for long time, might develop side hyperglycemia, weight change, osteoporosis due to it vivo non-selectivity. Herein, we liquid chromatography-tandem mass spectrometry-based comprehensive targeted metabolomic profiling well radiographic imaging techniques study the of Dex treatment...
The relationship between lipid metabolism and bone mineral density (BMD) is still not fully elucidated. Despite the presence of investigations using osteoporotic animal models, clinical studies in humans are limited. In this work, untargeted lipidomics profiling liquid chromatography-mass spectrometry (LC-MS) analysis human serum samples was performed to identify profile associated with low (LBMD), a subsequent examination potential biomarkers related OP risk prediction or progression. A...
Dexamethasone (Dex) is a synthetic glucocorticoid (GC) drug commonly used clinically for the treatment of several inflammatory and immune-mediated diseases. Despite its broad range indications, long-term use Dex known to be associated with specific abnormalities in tissues organs. In this study, metabolomic effects on five different organs induced by chronic administration Sprague-Dawley rat model were investigated using chemical isotope labeling liquid chromatography-mass spectrometry (CIL...
Prolonged dexamethasone (Dex) administration leads to serious adverse and decrease brain heart size, muscular atrophy, hemorrhagic liver, presence of kidney cysts. Herein, we used an untargeted proteomic approach using liquid chromatography-tandem mass spectrometry (LC-MS/MS) for simultaneous identification changes in proteomes the major organs Sprague-Dawley (SD rats post Dex treatment. The comparative quantitative analysis brain, heart, muscle, tissues revealed differential expression...
Dexamethasone is a synthetic glucocorticoid medication vastly used to treat abnormal immune responses and inflammation. Although the well-established in medical community, prolonged treatment with high dosages of dexamethasone may lead severe adverse effects through mechanisms that are not yet well-known. Lipids large class hydrophobic molecules involved energy storage, signaling, modulation gene expression, membranes. Hence, untargeted lipidomics help unravel biochemical alterations...
T-cells play a significant role in the development of autoimmune diseases. The CD28-B7 costimulatory pathway is crucial for activating T-cells, and blocking this essential treating Therapeutic antibodies fusion proteins that target molecules like CD80, CD86, CTLA-4, CD28 have been developed to explore costimulation process as targeted treatments. To advance our understanding autoimmunity inhibition pathway, it an accurate, precise, direct method detecting quantifying soluble form these body...
According to studies, the microbiome may contribute emergence and spread of breast cancer. E. coli is one Enterobacteriaceae family recently found be present as part tissue microbiota. In this study, we focused on effect secretome free cells MCF-7 metabolism. Liquid chromatography–mass spectrometry (LC-MS) metabolomics was used study its role in intra- extracellular metabolites. A comparison made between secretome-exposed unexposed controls. Our analysis revealed significant alterations 31...
Extensive research developed assistive technologies (ATs) to improve mobility for people with vision impairment (PVI). However, a limited number of PVI rely on ATs mobility. One the factors contributing reliability and low acceptance is developers’ failure consider traits from target group’s perspective. Many developers researchers proposed solutions based their knowledge experiences, where have been excluded several studies except involvement in testing phases. Accordingly, this study aims...
RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to “Tissue Lipidomic Alterations Induced by Prolonged Dexamethasone Treatment”Adriana Zardini BuzattoAdriana BuzattoMore Adriana Buzattohttp://orcid.org/0000-0001-7977-4102, Abeer MalkawiAbeer MalkawiMore Malkawi, Essa M. SabiEssa SabiMore Sabi, Ahmed H. MujamammiAhmed MujamammiMore Mujamammi, Liang Li*Liang LiMore Lihttp://orcid.org/0000-0002-9347-2108, and Anas Abdel Rahman*Anas RahmanMore...