A5006158698- Hemoglobinopathies and Related Disorders
- Nanoparticles: synthesis and applications
- MicroRNA in disease regulation
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
- Synthesis and biological activity
- Circular RNAs in diseases
- vaccines and immunoinformatics approaches
- Extracellular vesicles in disease
- Vitamin D Research Studies
- Cancer therapeutics and mechanisms
- Cancer Immunotherapy and Biomarkers
- Bacteriophages and microbial interactions
- Adipokines, Inflammation, and Metabolic Diseases
- Computational Drug Discovery Methods
- Cancer-related molecular mechanisms research
- Moringa oleifera research and applications
- Cancer Risks and Factors
- Retinoids in leukemia and cellular processes
- Antibiotic Use and Resistance
- Ferroptosis and cancer prognosis
- Graphene and Nanomaterials Applications
- Research on Leishmaniasis Studies
- Nanomaterials for catalytic reactions
- Child Nutrition and Water Access
Taif University
2022-2024
Zagazig University
2023
Jouf University
2023
University of Nottingham
2020
In the present study, we utilized Stevia rebaudiana L. (SRLe) extract to in situ biosynthesize nanoscale alpha hematite (α-Fe2O3) nanoparticles (NPs) with potent antioxidant, antimicrobial, and anticancer properties. SRLe-α-Fe2O3 was characterized using physiochemical analyses, including UV/Vis, FTIR, XRD, DLS, EDX, SEM, TEM studies. Among tested solvents, CHCl3/MeOH (2:1 v/v) SRL (least polar solvent) contained highest EY, TPC, antioxidant capacity of ~3.5%, ~75 mg GAE/g extract, IC50 =...
Nanoparticles are materials whose size is less than 100 nm. Because of their distinctive physical and chemical characteristics, nanoparticles have drawn considerable interest in a variety fields. Biosynthesis green environmentally friendly technology, which requires fewer reagents, precursors, catalysts. There various types nanomaterials, out trimetallic receiving recent years. Trimetallic possess unique catalytic, biomedical, antimicrobial, active food packaging, sensing applications as...
In this study, we report one-pot, single step synthesis of silver nanoparticles stabilized by using arbutin. The concentration reducing agent (NaBH4) used in the preparation was kept at double, and arbutin as a stabilizing agent. confirmation prepared done color change UV-Vis surface plasmon resonance peak 435 nm spectrum. Size dispersion carried out Dynamic Light Scattering (DLS) charge on nanoparticles. Stability analyzed Zeta potential. A strong negative indicated that are well throughout...
Cancer and different types of tumors are still the most resistant diseases to available therapeutic agents. Finding a highly effective anticancer drug is first target concern thousands designers. In our attempts address this concern, new pyrazine derivative, 1-(5-bromopyrazin-2-yl)-1-[3-(trifluoromethyl)benzyl]urea (BPU), was designed via structural optimization synthesized investigate its anticancer/antitumor potential. The in-vitro properties BPU were evaluated by MTT assay using selected...
In the current study,
The green synthesis of nanoparticles (NPs) is attracting enormous attention as a new area study that encompasses the development and discovery agents for their utilization in different fields, such pharmaceuticals food. Nowadays, use plants, particularly medicinal creation NPs has emerged safe, ecofriendly, rapid, simple approach. Therefore, present aimed to Saudi mint plant silver (AgNPs) evaluate antimicrobial antioxidant activities AgNPs compared extract (ME). A phenolic flavonoid...
<h3>Abstract</h3> Background/Aim: DNA methylation is the most studied epigenetic modification in cancer. Ten-eleven translocation enzymes (TET) catalyze oxidation of 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) DNA. In current research, we aimed evaluate role 5-hmC and TET non-small cell lung cancer (NSCLC) patients their possible association with outcomes. Patients Methods: ELISA was used measure levels genomic qRT-PCR TET1, TET2, TET3 mRNAs expression NSCLC tissues paired...
Hepatitis C virus (HCV) chronic infection is a major causative factor for several liver diseases, including cirrhosis, cell failure, and hepatocellular carcinoma. The HCV has seven genotypes. Genotype 4 the most prevalent genotype in Middle East, Saudi Arabia, followed by 1. affects response to different treatments progression of disease. Currently, combinations direct-acting antiviral drugs (DAAs) approved treatment achieve high cure rates with minimal adverse effects. Because real-world...
Cancer is a deadly disease characterized by abnormal cell proliferation. Chemotherapy one technique of cancer treatment. Cyclophosphamide (CYP) the most powerful chemotherapy medication, yet it has serious adverse effects. It an antimitotic medicine that regulates proliferation and primarily targets quickly dividing cells, been related to varying levels infertility in humans. In current study, we assessed biochemical, histological, microscopic evaluations testicular damage following...
Acute myeloid leukemia (AML) is a heterogenous hematological malignancy with poor long-term survival. New drugs which improve the outcome of AML patients are urgently required. In this work, activity and mechanism action cytotoxic indole alkaloid Jerantinine B (JB), was examined in cells. We used combination proliferation apoptosis assays to assess effect JB on cell lines patient samples, BH3 profiling being performed identify early effects drug (4 h). Phosphokinase arrays were adopted...
Alpha-thalassemia (α-thalassemia) is one of the most common monogenic diseases in Saudi Arabia and associated with significant morbidity. Premarital testing programs reduce burden hemoglobinopathy disorders, ongoing monitoring required. We aimed to explore molecular nature α-globin genes identify genotypes regions a high risk α-thalassemia Arabia.This retrospective study was conducted between January 2021 December 2022. Six hundred twenty-five samples from patients microcytic hypochromic...
Breast cancer is the leading cause of cancer-related death among women in Saudi Arabia. Many studies have suggested a strong correlation between vitamin D and multiple types cancer. This study included 100 female patients with early or locally advanced breast Patients were recruited from King Faisal Hospital Taif City, Arabia, January 2020 to September 2020. We aimed association serum D, calcium, interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α) chemerin progression. The control...
Background: The major obstacle to stem cell transplantation (SCT) therapy is finding a matching family donor. In Saudi Arabia, 60% of pediatrics and 30% adult patients cannot find donor in their family. Little evidence has been published worldwide assess women’s acceptance SCT, so this research analyzed awareness SCT the refusal rates for donation among females.
 Methods: A cross-sectional study was conducted with females living Arabia. Voluntary questionnaires 20 multiple-choice...
In the present study, formation of a heterodimer involving both epidermal growth factor receptor (EGFR) and human 2 (HER2) has been explored as potential therapeutic mechanism to inhibit progression breast cancer. Virtual screening using molecular docking resulted in three hit compounds (ZINC08382411, ZINC08382438, ZINC08382292) with minimum binding scores commonly receptors. Further, MD simulation analysis these complexes illustrated high stability EGFR HER2. RMSD showed that ZINC08382411...
One of the viral diseases that affect millions people around world, particularly in developing countries, is Japanese encephalitis (JE). In this study, conserved protein virus, is, non-structural 5 (NS5), was used as a target for and compound library 749 antiviral molecules screened against NS5. The current study employed machine learning-based virtual screening combined with molecular docking. Here, three hits (24360, 123519051 213039) had lower binding energies (< −8 kcal/mol) than...
Leukemia is the fifth most common cancer in Saudi Arabia. The aim of this study was to assess various patterns leukemia associated with age, gender, and nationality region.
A prevalent food-borne pathogen,
Background: Hyperglycemic patients are at a high risk of COVID-19 severity. Neutrophils have been considered critical effector cells in development. Vitamin D deficiency is prevalent hyperglycemic and was found to adversely associate with the neutrophil count. Aim: The goal this work evaluate characteristics diabetic pre-diabetic discovered changes neutrophils their correlation, if any, disease clinical presentation. Patients Methods: study included total (514) Covid-19 positive confirmed by...