A5019031041- Head and Neck Cancer Studies
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer Risks and Factors
- MicroRNA in disease regulation
- Inflammatory mediators and NSAID effects
- Estrogen and related hormone effects
- Circular RNAs in diseases
- Peptidase Inhibition and Analysis
- DNA Repair Mechanisms
- Lung Cancer Research Studies
- Immunotherapy and Immune Responses
- BRCA gene mutations in cancer
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Management of metastatic bone disease
- Genetic factors in colorectal cancer
- Glycosylation and Glycoproteins Research
- Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Multiple Myeloma Research and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Vitamin D Research Studies
- Brain Metastases and Treatment
Zagazig University
2011-2024
Taif University
2023
Jouf University
2023
Cairo University
2007
Abstract Background: Laryngeal squamous cell carcinoma (LSCC) is a challenging malignancy, and identifying effective treatment strategies reliable biomarkers crucial. This study aimed to evaluate the impact of combined neoadjuvant chemotherapy chemoradiotherapy on outcomes, as well assess potential SIK-1 diagnostic prognostic biomarker in LSCC. Methods: A total 108 patients with locally advanced LSCC were treated induction followed by definitive radiotherapy. Treatment responses assessed,...
<h3>Abstract</h3> Background/Aim: DNA methylation is the most studied epigenetic modification in cancer. Ten-eleven translocation enzymes (TET) catalyze oxidation of 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) DNA. In current research, we aimed evaluate role 5-hmC and TET non-small cell lung cancer (NSCLC) patients their possible association with outcomes. Patients Methods: ELISA was used measure levels genomic qRT-PCR TET1, TET2, TET3 mRNAs expression NSCLC tissues paired...
Malignant pleural mesothelioma (MPM) is a malignant tumor of the mesothelial lining thorax. It has been related to frequent exposure asbestos. Diagnosis considered criticizing problem for clinicians. Early diagnosis and sufficient surgical excision MPM are cornerstone success factors management early MPM. Glutathione peroxidase-1 (GPX1) an intracellular protein found be extensively distributed in all cells, it belongs GPX group. In current study, we included ninety-eight patients with that...
Squamous cell carcinoma of the head and neck (HNSCC) is a globally prevalent form cancer with significant morbidity mortality rates. The present study examines relationship serum pro-inflammatory cytokines leptin levels effectiveness therapy in individuals HNSCC their potential role as biomarkers for treatment response toxicity. Induction chemotherapy concomitant chemoradiotherapy were evaluated efficacy safety 52 HNSCC. Both toxicity evaluated, Interlukin-1 beta (IL-1β), Interlukin-2...
Background/Objectives: Laryngeal squamous cell carcinoma (LSCC) is the most prevalent form, accounting for nearly 95% of laryngeal cancer. This study evaluates effectiveness chemotherapy and radiation therapy combined treating LSCC, along with exploring miR-449a as a potential biomarker predicting treatment response prognosis in LSCC patients. Patients Methods: The had 81 patients advanced cancer 50 healthy controls. Chemotherapy was given two cycles, followed by an evaluation response....
Cancerous inhibitor of protein phosphatase 2A (CIP2A) has been identified as one the most commonly altered proteins in human cancers.It blocks tumor-suppressive action (PP2A) complex and enhances malignancy.Thirty-five patients with squamous cell carcinoma oral cavity underwent surgical resection tumor.CIP2A was assessed by quantitative real-time PCR resected tumor tissues their adjacent normal tissues.CIP2A found to be overexpressed all (OSCC) specimens comparison surrounding tissue.CIP2A...
Circulating long non-coding RNAs (lncRNA) are dysregulated in several diseases, especially cancers, e.g. non-small-cell lung cancer (NSCLC). Of specific notice this regard is growth arrest-specific 5 gene (lncRNA GAS5), which principally recognised as a tumor suppressor numerous cancers. Functionally, GAS5 involved arresting cellular and induction of apoptosis. We analysed plasma expression by qRT-PCR 100 patients with NSCLC before after tumour resection surgery. reported downregulation...
Breast cancer (BC) is among the most widespread malignant tumors in women. In current study, we evaluated role of miR-31 BC patients and its relation to different prognostic, clinical, pathological features.MiR-31 levels were determined by RT-PCR adjacent normal breast tissues from 100 patients. diagnosis was established through histopathological examinations. The expression estrogen receptor (ER), progesterone (PR), human epidermal growth factor 2 (HER2) all using...
Breast cancer is the leading cause of cancer-related death among women in Saudi Arabia. Many studies have suggested a strong correlation between vitamin D and multiple types cancer. This study included 100 female patients with early or locally advanced breast Patients were recruited from King Faisal Hospital Taif City, Arabia, January 2020 to September 2020. We aimed association serum D, calcium, interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α) chemerin progression. The control...
Abstract Background Ovarian cancer is the most common gynecological malignancy. In patients with advanced ovarian cancer, some biological parameters have prognostic implementations. P27 kip1 an inhibitor of a cycline-dependent kinase, its loss, can contribute to tumor progression. Objective This study aimed examine importance KIP1 protein in predicting prognosis and response neoadjuvant chemotherapy epithelial compare outcomes immunohistochemistry Quantitative Real-time PCR. Patients methods...
Abstract Lung cancer, primarily nonsmall cell lung cancer (NSCLC), is a leading cause of cancer-related fatalities globally. Due to late detection, the 5-year survival rate for NSCLC remains low. Therefore, current research aimed assess diagnostic and prognostic value serum exosomal miR-874 levels in patients. This study involved 161 patients 80 control subjects. Blood samples were collected from all participants, MiR-874 quantified using quantitative reverse transcription-polymerase chain...
Background and objective Head neck squamous cell carcinoma (HNSCC) is a prevalent cancer type that affects the mucosal lining of upper aerodigestive tract. Soluble programmed death-ligand 1 (sPD-L1) significant factor in hindering T cells' function, which prevents cells from being detected by immune system. This means sPD-L1 an essential component evasion cancer. study aimed to explore potential as prognostic biomarker for patients with HNSCC undergoing concurrent chemotherapy radiation...
17500 Background: Caspase-3 activation is an essential step in programmed cell death (apoptosis) and cytotoxic drug-induced apoptosis mediated by caspase-2 caspase-3. The following study was designed to evaluate the correlation between clinical outcome patients with diffuse large B-cell lymphoma. Methods: determined both immunohistochemistry quantitative reverse-transcription PCR 49 previously untreated Results: positive 69.4% of immunostaining Tumor cells displayed a cytosolic expression...
The genes involved in DNA repair system play a crucial role the protection against mutations .It has been hypothesized that functional deficiencies highly conserved processes resulting from polymorphic variation may increase genetic susceptibility to breast cancer.There are multiple pathways different types of damage and maintain genomic integrity among them is nucleotide excision (NER) base (BER) pathways.Aim & methods:The aim present study was examine relation between gene polymorphisms...
Breast cancer (BC) is one of the leading causes mortality in women. Glutathione S-transferase (GSTT1) involved activation detoxification reactions and catalysis chemicals conjugation with glutathione. GSTT1 genotype a limiting factor for some environmental diseases. Epigenetic changes have an essential role BC through inappropriate interaction between genomic risk factors.This study was directed to explore association genetic variations its methylation status Egyptian women.This included 100...
Background: There is a relation between the severity of pain and common symptoms in patients with metastatic cancer.Aim: This study was done to explore this among Egyptian advanced cancer.Methods: The included 120 adult cancer from two centers Cairo Sharkia, Egypt.Pain other were assessed using Arabic version Edmonton Symptom Assessment System (ESAS).The Eastern Cooperative Oncology Group (ECOG) performance scale used assess status.Results: prevalence ESAS high (tiredness, 94%; drowsiness,...
Introduction:Adjuvant radiotherapy is considered one of treatment options for locally advanced breast cancer.Thyroid gland not an organ at risk in supraclavicular (SC) nodal radiation therapy (RT) cancer.Objectives: Comparison the impact 2 different RT techniques on thyroid gland; group (I) conventional two-dimensional SC node and Group (II) three-dimensional conformal (3DCRT) planning node.Method: Twenty (20) patients with cancer received RT, evaluation functions both groups, including...