A5012355092- Circular RNAs in diseases
- Hormonal Regulation and Hypertension
- Cancer-related molecular mechanisms research
- Rheumatoid Arthritis Research and Therapies
- Cardiac Imaging and Diagnostics
- MicroRNA in disease regulation
- Acute Myocardial Infarction Research
- Renin-Angiotensin System Studies
- Coronary Interventions and Diagnostics
- Lipoproteins and Cardiovascular Health
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Biomarkers in Disease Mechanisms
- Toxin Mechanisms and Immunotoxins
- Cancer, Lipids, and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Cytokine Signaling Pathways and Interactions
- Asthma and respiratory diseases
- Trace Elements in Health
- DNA Repair Mechanisms
- Ferroptosis and cancer prognosis
- Adipokines, Inflammation, and Metabolic Diseases
- Bone Metabolism and Diseases
- Diabetes and associated disorders
Zagazig University
2016-2025
The potential use of microRNAs (miRNAs) as ideal tumor markers has been the focus recent research.Our hypothesis was that circulating miRNAs are differentially expressed in pretherapeutic sera breast cancer patients compared to controls.Using real-time quantitative polymerase chain reaction (qPCR) analysis, levels 5 candidate (miR10b, miR34a, miR155, miR195 and miR16) were quantified control individuals.Levels preoperative showed significant upregulation 3.36 fold rise miR10b (p<0.001), a...
The early imbalances of trace elements in type 1 diabetes (T1D) may cause disturbance glucose metabolism and more oxidative stress that enhance the development insulin resistance diabetic complications. We aim to evaluate serum level selenium (Se), zinc (Zn), magnesium (Mg), copper (Cu), degree their relations glycemic control children with T1D.A case-control study which included 100 40 healthy age, sex, ethnicity-matched as a group. were divided into poor good controlled patients according...
Background: Long non-coding RNAs (NKILA and LINC00993) are downregulated in breast cancer (BC) can have potential use as a novel tumor biomarker. The Aim of the work is to investigate LncRNAs cytokines (NF-κB CXCL-1) biomarkers BC. Methods: This Cross-sectional study included sixty-four pairs surgically resected human tissues adjacent tissues. Expressions (NKILA, (NF-κB, CXCL1) were detected using real-time quantitative polymerase chain reaction (qPCR) analysis, Results: There was...
DNA methylation status is one of the most prevalent molecular alterations in human cancers. Identification powerful diagnostic and prognostic biomarkers for hepatocellular carcinoma (HCC) without a biopsy urgently required.The purpose this study was to determine RASSF1A SOCS-1genes as non-invasive biomarker HCC identification prognosis.Methylation specific-PCR technique performed recognize SOCS-1 genes 100 patients with HCC, liver cirrhosis (LC) but were considered cirrhotic control group...
Bone disease in rheumatoid arthritis (RA) is a complex phenomenon where genetic risk factors have been partially evaluated. In the present study, we aimed to evaluate relationship between polymorphisms of receptor activator nuclear factor kappa B (RANK) gene; ligand (RANKL) and RANKL levels with osteoporosis postmenopausal RA patients.One hundred seventy-two female patients 176 age- sex-matched controls were enrolled study. All subjects genotyped for presence RANK C575T (rs1805034) C290T...
Recently, MicroRNAs polymorphisms and their serum expression have been linked to increase risk of various cancers. The aim this study was elucidate the association between single nucleotide miR-146a miR-196a-2 lung cancer risk. One hundred twenty patients 120 health controls were included in study. Genotyping for performed using polymerase chain reaction (PCR)-restriction fragment length polymorphism quantitative real-time PCR. Individuals carrying CG CC genotypes had significantly increased...
Adipokines produced by adipose tissue are directly linked to obesity and may contribute the pathogenesis of cancer. We hypothesized that genetic epigenetic modifications in adiponectin (ADIPOQ) gene their impact on serum ADIPOQ levels participate increasing breast cancer (BC) risk. The present study aimed investigate +45 T/G polymorphism, methylation status at CpG sites -74 nucleotides (nt) -283 nt gene, BC obese women.Serum was measured an enzyme-linked immunosorbent assay. polymorphism...