A5021390128- Mesenchymal stem cell research
- Asthma and respiratory diseases
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Rheumatoid Arthritis Research and Therapies
- Dermatology and Skin Diseases
- IL-33, ST2, and ILC Pathways
- RNA modifications and cancer
- Tissue Engineering and Regenerative Medicine
- Hepatitis C virus research
- Allergic Rhinitis and Sensitization
- Urinary and Genital Oncology Studies
- Neonatal Respiratory Health Research
- Bladder and Urothelial Cancer Treatments
- Estrogen and related hormone effects
- Nerve injury and regeneration
- Pediatric health and respiratory diseases
- Bone Metabolism and Diseases
- Neurogenesis and neuroplasticity mechanisms
- Ovarian function and disorders
- Psoriasis: Treatment and Pathogenesis
- Liver Disease Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
- Urticaria and Related Conditions
Zagazig University
2014-2024
Bridge University
2021
Abstract Irisin is an exercise‐regulated myokine inducing browning of white adipose tissue and has gained interest as a potential new strategy to combat obesity its associated disorders, such type 2 diabetes mellitus (T2DM). The aim this study evaluate the circulating serum irisin levels in T2DM also elucidate possible relationships between with anthropometric metabolic parameters T2DM. One hundred fifty newly diagnosed patients well 150 nondiabetic control subjects were enrolled study....
Early diagnosis of non-small cell lung cancer (NSCLC) is essential for patient treatment and prognosis. Long noncoding RNA (lncRNA) have potential roles in tumor initiation differentiation. The objective this study was to investigate whether the circulating lncRNA, growth arrest-specific transcript 5 (GAS5) SOX2 overlapping (SOX2OT), could be used as noninvasive biomarkers NSCLC diagnosis. Moreover, we aimed at evaluating association between lncRNA clinicopathological features order predict...
In clinical practice, there is still a need for novel biomarkers, which can reliably rule in or out acute coronary syndrome (ACS) immediately on admission. This of particular interest patients with unstable angina (UA) and non-ST-segment elevation myocardial infarction (NSTEMI) whom diagnostic uncertainty high. The aim the present study to evaluate potential role miRNA-499 miRNA-210 as molecular biomarkers early diagnosis UA NSTEMI suspected presented at emergency unit. A total 110...
The matrix metalloproteinases 1 and 3 (MMP1 MMP3) are thought to be important in destructive joint changes seen rheumatoid arthritis (RA) osteoarthritis (OA) diseases. aim of this study was analyze whether functional polymorphisms the promoter region MMP1 MMP3 genes were associated with RA OA. (-1607 1G/2G) (-1171 5A/6A) screened by polymerase chain reaction-restriction fragment length polymorphism 100 patients (RA), (OA), controls. Serum levels measured enzyme-linked immunosorbent assay....
Endothelial dysfunction plays an important role in the pathogenesis of diabetic vascular disease, including nephropathy (DN). nitric oxide synthase (eNOS) gene polymorphisms that affect eNOS activity are associated with endothelial dysfunction. The aim this study was to evaluate association three (894G>T, -786T>C, and 27-bp-VNTR) risk DN among type 2 patients. A total 400 patients were enrolled study. group comprised 200 patients; diabetics without another Genetic analysis for done all...
Background: The potential involvement of type 2 diabetes mellitus (T2DM) as a risk factor for colon cancer (CC) has been previously reported. Epigenetic changes, such deregulation long non-coding RNA (lncRNA) and microRNA (miR), have linked to the advancement CC; however, effects high glucose levels on their and, in turn, remain unexplored. Methods: Fifty patients had dual diagnosis CC T2DM, 60 with without were included study. qRT-PCR was used examine expression lncRNA ANRIL miR-186-5p...
We examined the effect of placenta-derived MSCs (PDMSCs) injection intraregionally and intraperitoneally on healing induced full thickness mice skin wounds; moreover, mechanisms by which exert their effects were also studied. Sixty female divided into three groups after induction wound; untreated group, wounded injected with derived from human placenta or intraregionally. Skin biopsies obtained 7 12 days wound incision for histological examinations, detection vascular endothelial growth...
A growing interest to understand the signaling pathways mediating obesity-induced muscle atrophy is given. Metformin (Met) was reported possess positive effects on preventing damage and promoting mass maintenance. The aim of present study investigate involved in Met effect obesity induced atrophy.Thirty adult male albino rats were assigned into two groups: normal chew diet fed group as control (C; n = 10) high-fat-diet (HFD) ( 20). After 16 weeks, HFD-fed animals subdivided groups; HFD...