A5010665385- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- Bee Products Chemical Analysis
- Diverse Scientific Research Studies
- vaccines and immunoinformatics approaches
- COVID-19 Clinical Research Studies
- Synthesis and biological activity
- Toxin Mechanisms and Immunotoxins
- Pharmacogenetics and Drug Metabolism
- Essential Oils and Antimicrobial Activity
- Oral microbiology and periodontitis research
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Cholinesterase and Neurodegenerative Diseases
- Circular RNAs in diseases
- Pain Management and Placebo Effect
- Transgenic Plants and Applications
- Medicinal Plant Research
- Herbal Medicine Research Studies
- Immunotoxicology and immune responses
- Air Quality Monitoring and Forecasting
- Photodynamic Therapy Research Studies
- Wnt/β-catenin signaling in development and cancer
- Viral gastroenteritis research and epidemiology
- Scoliosis diagnosis and treatment
Taif University
2021-2024
SARS-CoV-2, an emerged strain of corona virus family became almost serious health concern worldwide. Despite vaccines availability, reports suggest the occurrence SARS-CoV-2 infection even in a vaccinated population. With frequent evolution and expected multiple COVID-19 waves, improved preventive, diagnostic, treatment measures are required. In recent times, phytochemicals have gained attention due to their therapeutic characteristics suggested as alternative complementary treatments for...
In spite of the availability vaccine, health burden associated with COVID-19 pandemic continues to increase. An estimated 5 million people have died SARS-CoV-2 infection. Analysis evolution and genomic diversity can provide sufficient information reduce pandemic. This study focused conduct worldwide surveillance. About 7.6 data were analyzed during 2019 2022. Multiple sequence alignment was conducted by using maximum likelihood method. Clade GK (52%) most predominant followed GRY (12%), GRA...
Glycogen synthase kinase-3 (GSK3β), a serine/threonine protein kinase, has been discovered as novel target for anticancer drugs. Although GSK3β is involved in multiple pathways linked to the etiology of various cancers, no specific inhibitor authorized cancer therapy. Most its inhibitors have toxicity effects therefore, there need develop safe and more potent inhibitors. In this study, library 4,222 anti-cancer compounds underwent rigorous computational screening identify potential...
The current study aimed to evaluate ochratoxin A oral mycotoxin and the dietary intake effects of four honey varieties ( Nigella sativa , moringa, sidr, pumpkin–coded as NS, MO, SI, PU respectively), on TNF- α immunology response, lactic acid bacteria microbial louds Lactobacilli Bifidobacteria ), β -glucuronidase enzyme activity, some hematological biochemical parameters mice. MO Honey Group + OTA Infection had highest value response at 445.17 pg/mL. It was followed by 360.88 pg/mL, while...
ABSTRACT Hyper-transmissibility with decreased disease severity are typical characteristics of Omicron variant. To understand this phenomenon, we used various bioinformatics approaches to analyze randomly selected genome sequences (one each) the Gamma, Delta, and variants submitted NCBI from 15 31 December 2021. We show that: (i) Pathogenicity SARS-CoV-2 decreases in order: Wuhan > Gamma Delta Omicron; however, antigenic property follows Delta. (ii) Spike RBD has lower pathogenicity but...
Scientific evidence shows a positive association in the etiopathogenesis of periodontitis and chronic kidney disease (CKD). Various confounding factors, such as obesity, diabetes, inflammation, also play significant role progression CKD, which remains unexplored. We hypothesise red complex bacteria with various factors associated disease. The study comprised total 120 participants categorised into 4 groups: control group (C), subjects without CKD (P), periodontally healthy (CKD), having both...
(1) Background: Odontogenic keratocysts (OKCs) are enigmatic developmental cysts that deserve special attention due to their heterogeneous appearance in histopathological characteristics and high recurrence rate. Despite several nomenclatures for classification, clinicians still confront challenges its diagnosis predicting recurrence. This paper proposes an ensemble deep-learning-based prognostic prediction algorithm, the of sporadic odontogenic keratocysts, on hematoxylin eosin stained...
The wild-type SARS-CoV-2 has continuously evolved into several variants with increased transmissibility and virulence. Delta variant which was initially identified in India created a devastating impact throughout the country during second wave. While efficacy of existing vaccines against latest remains unclear, extensive research is being carried out to develop potential antiviral drugs through approaches like silico screening drug-repurposing. This study aimed conduct docking-based virtual...
Vitamin C, (ascorbic acid), vitamin D (cholecalciferol) and zinc (zinc sulfate monohydrate) supplements are important in immunity against coronavirus disease-2019 (COVID-19). However, a limited number of studies have been conducted on the association vitamins with reduced risks COVID-19 infection. This study aims to evaluate as treatment options reduce severity COVID-19. Data were collected from 962 participants 13 December 2020 4 February 2021. The presence was confirmed by qRT-PCR....
Gastric cancer is the fifth most frequent and third major cause of mortality worldwide. Helicobacter pylori, a bacterial infection linked with GC, injects cytotoxin-associated antigen A (CagA; an oncoprotein) into host cells. When phosphorylated CagA protein enters cell, it attaches to other cellular components, interfering normal signaling pathways. plays important role in progression GC by interacting phosphatidylserine cell membrane. Therefore, disrupting CagA-phosphatidylserine...
Syphilis, a sexually transmitted infection caused by the spirochete Treponema pallidum, has seen resurgence over past years. T. pallidum is capable of early dissemination and immune evasion, disease continues to be global healthcare burden. The purpose this study was design multi-epitope immunogen through an immunoinformatics-based approach. Multi-epitope immunogens constitute carefully selected epitopes belonging conserved essential bacterial proteins. Several physico-chemical...
Pesticides kill neurons, but the mechanism leading to selective dopaminergic loss in Parkinson's disease (PD) is unknown. Understanding pesticide's effect on neurons (DA) can help screen and treat PD. The critical uptake of pesticides by membrane receptors at DA hypothesized activate a signaling cascade accelerate degeneration. Using MPTP as reference, we demonstrate mechanisms eleven crucial through molecular docking, protein networks, regulatory pathways, prioritization key...
Aspergillus fumigatus is a universal pathogenic mold. Invasive aspergillosis disease can affect persons with weakened immune systems. Natural immunostimulators are very important in improving the response contradiction to various diseases. In current study four varieties of honey samples (nigella, moringa, sidr, and pumpkin honey) which coded as NS, MO, SI, PU honey; were used evaluate diastase invertase enzyme activities. Eight groups mice fed varieties, after injecting half them invasive...
The perilous increase of Pseudomonas aeruginosa resistance and its great ability to produce several virulence factors is an emergent global health problem. Further investigation docking study were further performed predict the ideal identified compounds propolis ethanolic extract with high affinity interact some selected receptors. results showed that had a rich repertoire polyphenols, cynarin, ellagic acid, chrysin detected as major compounds. Furthermore, potent antioxidant activity....
Circulating long non-coding RNAs (lncRNA) are dysregulated in several diseases, especially cancers, e.g. non-small-cell lung cancer (NSCLC). Of specific notice this regard is growth arrest-specific 5 gene (lncRNA GAS5), which principally recognised as a tumor suppressor numerous cancers. Functionally, GAS5 involved arresting cellular and induction of apoptosis. We analysed plasma expression by qRT-PCR 100 patients with NSCLC before after tumour resection surgery. reported downregulation...
Breast cancer (BC) is among the most widespread malignant tumors in women. In current study, we evaluated role of miR-31 BC patients and its relation to different prognostic, clinical, pathological features.MiR-31 levels were determined by RT-PCR adjacent normal breast tissues from 100 patients. diagnosis was established through histopathological examinations. The expression estrogen receptor (ER), progesterone (PR), human epidermal growth factor 2 (HER2) all using...
Clinical pharmacology and toxicology are considered nowadays two complementary indispensable medical disciplines that allowed clinicians to achieve the optimal therapeutic effect of a several substance, but also characterize their toxicity threshold. The contribution bioinformatics tools databases in these fields has provided key elements, sometimes impossible explain during early clinical phases. In this context, some computational approaches were used work investigate molecular weight...
Cathepsin L (CTSL) expression is dysregulated in a variety of cancers. Extensive empirical evidence indicates their direct participation cancer growth, angiogenic processes, metastatic dissemination, and the development treatment resistance. Currently, no natural CTSL inhibitors are approved for clinical use. Consequently, novel inhibition strategies an urgent necessity. In this study, combined machine learning (ML) structure-based virtual screening strategy was employed to identify...
(1) Background: Dental pulp stem cells (DPSCs) are derived from tissue lodged within human teeth and mesenchymal in origin. These DPSCs have been demonstrated to dissociate into clusters of various cell lineages very easy isolate, culture, expand. Melatonin, a multifaceted molecule with spectrum effects the body, is known influence viability, proliferation, differentiation, but little about impact melatonin has on capacity differentiate adipocytes, osteocytes, chondrocytes. The primary...
Transmission and increase in cases fatalities of coronavirus disease-2019 (COVID-19) are significantly influenced by the parameters weather, human activities population factors. However, study gap on seasonality COVID-19 impact environmental factors pandemic Saudi Arabia is present. The main aim to evaluate environment pandemic. Data were analyzed from January 2020 July 2021. generalized estimating equation (GEE) was used determine effect variables longitudinal outcomes. Spearman's rank...
Clostridium histolyticum is a Gram-positive anaerobic bacterium belonging to the genus. It produces collagenase, an enzyme involved in breaking down collagen which key component of connective tissues. However, antimicrobial resistance (AMR) poses great challenge combating infections caused by this bacteria. The lengthy nature traditional drug development techniques has resulted shift computer-aided design and other modern discovery approaches. above method offers cost-effective means for...
Abstract Nowadays, the physiopathological and molecular mechanisms of multiple diseases have been identified, thus helping scientists to provide a clear answer, especially those ambiguities related chronic illnesses. This has accomplished in part through contribution key discipline known as bioinformatics. In this study, bioinformatics approach was applied on four compounds identified Centaurea tougourensis , using two axes research: an silico study predict characteristics, medicinal...