A5026465125- vaccines and immunoinformatics approaches
- Pneumonia and Respiratory Infections
- Microbial infections and disease research
- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
- Vibrio bacteria research studies
- Influenza Virus Research Studies
- Computational Drug Discovery Methods
- Bacterial Genetics and Biotechnology
- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- Aquaculture disease management and microbiota
- Machine Learning in Bioinformatics
- Vector-borne infectious diseases
- Viral gastroenteritis research and epidemiology
- Contemporary Christian Leadership and Education
- Tuberculosis Research and Epidemiology
- RNA and protein synthesis mechanisms
- Biochemical and Structural Characterization
- Toxin Mechanisms and Immunotoxins
- Antibiotic Resistance in Bacteria
- T-cell and B-cell Immunology
- Chronic Lymphocytic Leukemia Research
- Bacterial Infections and Vaccines
- Probiotics and Fermented Foods
Universidade Federal de Minas Gerais
2021-2025
Universidade Federal do Triângulo Mineiro
2019
Pneumonia is an infectious disease caused by bacteria, viruses or fungi that results in millions of deaths globally. Despite the existence prophylactic methods against some major pathogens disease, there no efficient prophylaxis atypical agents such as Mycoplasma pneumoniae, a bacterium associated with cases community-acquired pneumonia. Because morphological peculiarity M. which leads to increased resistance antibiotics, studies prospectively investigate development vaccines and drug...
BACKGROUND Rickettsia is a genus of Gram-negative bacteria that causes various diseases, including epidemic typhus, Rocky Mountain spotted fever, and Mediterranean fever. Ticks transmit these diseases commonly found in developing regions with poor sanitation. As result, it difficult to estimate the number cases, making challenging create prevention diagnostic mechanisms. OBJECTIVES Thus, this study aimed develop an silico multi-epitope vaccine against Rickettsia. METHODS Eight proteins were...
Leprosy is caused by Mycobacterium leprae and lepromatosis. Most of the affected population lives in low-income countries may take up to 10 years show any clinical signs, which how physicians diagnose it. However, due progressive cell damage, early diagnosis very important. The best way confirm leprosy through bacilloscopic, only confirms has low accuracy or PCR, that requires specialized operators expensive. Since bacteria are fastidious do not grow culture media, therefore, diagnosing lab...
Syphilis, a sexually transmitted infection caused by the spirochete Treponema pallidum, has seen resurgence over past years. T. pallidum is capable of early dissemination and immune evasion, disease continues to be global healthcare burden. The purpose this study was design multi-epitope immunogen through an immunoinformatics-based approach. Multi-epitope immunogens constitute carefully selected epitopes belonging conserved essential bacterial proteins. Several physico-chemical...
The genus
The Gram-negative bacillus Serratia marcescens, a member of Enterobacteriaceae family, is an opportunistic nosocomial pathogen commonly found in hospital outbreaks that can cause infections the urinary tract, bloodstream, central nervous system and pneumonia. Because S. marcescens strains are resistant to several antibiotics, it critical need for effective treatments, including new drugs vaccines. Here, we applied reverse vaccinology subtractive genomic approaches silico prediction potential...
Pertussis is a highly contagious respiratory disease caused by Bordetella pertussis, Gram-negative bacterium described over century ago. Despite broad vaccine coverage and treatment options, the remerging as public health problem especially in infants older children. Recent data indicate re-emergence of related to bacterial resistance immune defences decreased effectiveness, which obviously suggests need new effective vaccines drugs. In an attempt contribute with solutions this great...
Vibriosis and cholera are serious diseases distributed worldwide caused by six marine bacteria of the Vibrio genus. Thousands deaths occur each year due to these illnesses, necessitating development new preventive measures. Presently, existing vaccine demonstrates an effectiveness approximately 60%. Here we describe a multi-epitope vaccine, 'vme-VAC/MST-1' based on targets identified reverse vaccinology epitopes predicted immunoinformatics, two currently effective tools for predicting...
The genus Rickettsia belongs to the Proteobacteria phylum and these bacteria infect animals humans causing a range of diseases worldwide. is divided into 4 groups despite public health threat knowledge accumulated so far, mandatory intracellular behaviour limitation for in vitro culture makes it difficult create new vaccines drug targets bacteria. In an attempt overcome limitations, pan-genomic approaches has used 47 genomes Rickettsia, order describe species similarities genomics islands....