A5011685116- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Nail Diseases and Treatments
- Plant Pathogens and Fungal Diseases
- COVID-19 Clinical Research Studies
- vaccines and immunoinformatics approaches
- Antimicrobial Peptides and Activities
- Dermatological and COVID-19 studies
- Cytomegalovirus and herpesvirus research
- Yeasts and Rust Fungi Studies
- Women's cancer prevention and management
- Tuberculosis Research and Epidemiology
- Long-Term Effects of COVID-19
- Metal and Thin Film Mechanics
- Parasitic Infections and Diagnostics
- Pediatric health and respiratory diseases
- Cutaneous lymphoproliferative disorders research
- Science and Education Research
- Inflammasome and immune disorders
- Insects and Parasite Interactions
- Mycobacterium research and diagnosis
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
- Research on Leishmaniasis Studies
- Parasites and Host Interactions
Universidade Federal do Triângulo Mineiro
2015-2024
Hospital for Tropical Diseases
2010
Cryptococcosis is an important fungal infection in immunocompromised individuals, especially those infected with HIV. In Brazil, despite the free availability of antiretroviral therapy (ART) public health system, mortality rate due to Cryptococcus neoformans meningitis still high. To obtain a more detailed picture population genetic structure this species southeast we studied 108 clinical isolates from 101 patients and 35 environmental isolates. Among patients, 59% had fatal outcome mainly...
Cryptococcal infections are mainly caused by members of the Cryptococcus neoformans species complex (molecular types VNI, VNII, VNB, VNIV and AD hybrid VNIII). PCR mating type loci MLST typing using ISHAM-MLST consensus scheme were used to evaluate genetic relationship 102 (63 clinical 39 environmental) C. isolates from Uberaba, Brazil correlate obtained genotypes with clinical, antifungal susceptibility virulence factor data. All alpha. identified 12 known five new sequence (ST). Fourteen...
Cryptococcal meningitis (CM) remains as common life-threatening AIDS-defining illness mainly in resource-limited settings. Previous reports suggested that baseline cytokine profiles can be associated to fungal burden and clinical outcome. This study aimed evaluate the AIDS patients with CM its relation outcome at weeks 2 10. Thirty diagnosed by cerebrospinal fluid (CSF) Cryptococcus neoformans positive culture, India ink stain cryptococcal antigen test were prospectively evaluated. As...
This study aimed to characterize the immobilization of novel JIChis-2 peptide on Ti-6Al-4V alloy, widely used in biomedical sector. The antimicrobial activity was evaluated Gram-negative bacterium E. coli. Its occurred by inducing formation covalent bonds between N-terminus peptides and surface previously submitted acrylic acid polymerization via PECVD technique. Coated uncoated surfaces were characterized FTIR, AFM, SEM EDX. Studies global localized corrosion carried out, seeking explore...
Cryptococcus neoformans and C. gattii are the etiologic agents of cryptococcosis, a life-threatening disease in both immunocompromised immunocompetent hosts. Antifungal resistance has been evaluated using different methods, breakpoints, sizes test populations it is an emerging as significant issue worldwide. A total 176 (95 clinical 81 environmental) eight isolates were to determine minimal inhibitory concentration (MIC) according Clinical Laboratory Standards Institute method. 10.5%...
Paracoccidioidomycosis (PCM) is endemic to Latin America, where 10 million people may be infected with Paracoccidioides brasiliensis/Paracoccidioides lutzii and 1,600,000 individuals live human immunodeficiency virus (HIV) infection. An epidemiological overlapping of these infections occurred early in acquired syndrome era nearly 180 published cases. This study presents epidemiological, clinical, outcome profiles for 31 PCM patients HIV infection diagnosed a teaching hospital Brazil,...
This paper presents the case of a 75-year-old Brazilian man who developed inflammatory skin lesions with nodules and ulcerations on right forearm after an injury caused by handling barbed-wire Eucalyptus spp. logs. Histopathological assessment showed granulomatous processes yeasts similar to Cryptococcus Tissue fragments yielded when cultured that were identified as gattii VGII through biochemical reactions URA5-RFLP genotype. No evidence systemic involvement or any underlying...
Background Although Cryptococcus laurentii has been considered saprophytic and its taxonomy is still being described, several cases of human infections have already reported. This study aimed to evaluate molecular aspects C. isolates from Brazil, Botswana, Canada, the United States. Methods In this study, 100 phenotypically identified were evaluated by sequencing 18S nuclear ribosomal small subunit rRNA gene (18S-SSU), D1/D2 region 28S large (28S-LSU), internal transcribed spacer (ITS)...
Abstract Among Cryptococcus gattii genotypes, VGII has gained pivotal relevance in epidemiological, clinical and genetic contexts due to its association with several outbreaks temperate regions the high variability of this genotype. The aim study was compare 25 isolates C. from Southeast region Brazil previously described other country around world. isolates, 24 were one VGI. All them newly identified. Three new allele types (AT) (AT47 for URA5 locus, AT56 LAC1 AT96 IGS1 region) also...
Leprosy is caused by Mycobacterium leprae and lepromatosis. Most of the affected population lives in low-income countries may take up to 10 years show any clinical signs, which how physicians diagnose it. However, due progressive cell damage, early diagnosis very important. The best way confirm leprosy through bacilloscopic, only confirms has low accuracy or PCR, that requires specialized operators expensive. Since bacteria are fastidious do not grow culture media, therefore, diagnosing lab...
In recent decades, emerging fungal infections have changed the clinical mycology scenario as a consequence of advances in medical diagnostics and therapeutic procedures, long hospitalization times, growing number individuals with debilitating chronic diseases impaired immune systems. This report presents 19 months old Brazilian female patient who developed severe sepsis by an uncommon yeast. She was admitted at intensive care unit pneumonia, bronchopulmonary dysplasia, weight-for-age z score...
Cryptococcal meningitis (CM) is a life-threatening infection in HIV-infected patients, especially resource-limited settings. Cytokine patterns the cerebrospinal fluid (CSF) and sera may be related to clinical outcomes. This study aimed evaluate cytokine CSF of patients with CM as well cytokines produced by peripheral blood mononuclear cells (PBMCs) when stimulated LPS cryptococcal GXM. serum levels IL-2, IL-4, IL-8, IL-10, IL-12p40, IL-17A, INF-γ, TNF-α CXCL-10 were measured (CM+ HIV+) at...
Mycobacterium leprae and lepromatosis are gram-positive bacterial pathogens the causative agents of leprosy in humans across world. The elimination cannot be achieved by multidrug therapy alone, highlights need for new tools drugs to prevent emergence resistant strains.In this study, our contribution includes prediction vaccine targets putative against leprosy, using reverse vaccinology subtractive genomics. Six strains (4 2 strains, respectively) were used comparison taking strain TN as...
Statins are used as cholesterol-lowering drugs and may also have direct antimicrobial effects.To evaluate synergic interactions between simvastatin both amphotericin B fluconazole, against environmental strains of Cryptococcus neoformans isolated from captive birds' droppings.Experimental study conducted at Federal University Piauí, Parnaíba, in collaboration with Triângulo Mineiro, Uberaba, Brazil.Statin susceptibility tests samples were performed prescribed standards. Interactions...
Dermatomycoses are a group of diseases worldwide distributed and affect skin, hair nails. Several fungal species can be envolved keratinophilic fungi belonging to the genera Trichophyton, Microsporum Epidermophyton very common. These infections globally their incidence has progressively increased. Despite high incidence, few studies have been carried out in HIV-infected patients, regarding frequency, clinical presentations, identification. This study aimed evaluate some epidemiological...
<title>Abstract</title> Diabetes could be a risk factor for cryptococcal meningitis in immunocompetent individuals. A model frequently used to understand cellular changes diabetes consists of exposure high concentrations glucose vitro. In the airways, epithelial cells are crucial establishment <italic>cryptococcosis</italic>. We evaluated effects combination <italic>Cryptococcus neoformans</italic> and (at 5mM or 15mM) on human bronchial (BEAS-2B) 24h. No cytotoxic effect was observed...
Background/Objectives: Cytokine storm in severe COVID-19 is responsible for irreversible tissue damage and death. Soluble mediators from the TNF superfamily, their correlation with clinical outcome, use of receptors as a potent predictor outcome were evaluated. Methods: Severe patients had levels soluble superfamily quantified categorized according to (death versus survival). Statistical modeling was performed predict outcomes. Results: have elevated serum superfamily. Regardless sex age,...