A5069745918- Phytochemistry and Biological Activities
- Computational Drug Discovery Methods
- Sesquiterpenes and Asteraceae Studies
- Phytochemicals and Antioxidant Activities
- Natural Antidiabetic Agents Studies
- Essential Oils and Antimicrobial Activity
- Pharmacogenetics and Drug Metabolism
- Date Palm Research Studies
- Cholinesterase and Neurodegenerative Diseases
- Synthesis and biological activity
- Plant chemical constituents analysis
- Plant Toxicity and Pharmacological Properties
- Bee Products Chemical Analysis
- Genetics, Bioinformatics, and Biomedical Research
- Diverse Scientific Research Studies
- Muscle metabolism and nutrition
- Silymarin and Mushroom Poisoning
- Immunotoxicology and immune responses
- Postharvest Quality and Shelf Life Management
- Analytical Methods in Pharmaceuticals
- Enzyme Catalysis and Immobilization
- Pharmacological Effects of Natural Compounds
- Neurological Disorders and Treatments
- Algal biology and biofuel production
- Microbial Metabolic Engineering and Bioproduction
University of Batna 1
2021-2024
Laboratoire des Biomolécules
2022
Laboratoire de Chémo-biologie synthétique et thérapeutique
2022
Nowadays, plants bioactive compounds are considered as a new source of therapy, especially for the elaboration process more effective drugs. 80% actual drug substances purely natural and originate from plants, representing hope, treatment chronic illnesses. The aim this study is to characterize phytochemical composition C. tougourensis via gas chromatography-mass spectrometry (GC-MS) approach. This method allowed identification 45 in n-butanol extract (n-BuOH), which 12 were majority,...
The effect of three doses UV-C radiation (1, 3 and 6 kJ m−2) on conservation potential after harvest the Deglet-Nour date for five months storage at 10 °C was studied. Contents water, total sugar, carotenoids, proteins, polyphenols, flavonoids condensed tannins, as well browning index, enzyme activities polyphenoloxidase peroxidase antioxidant capacity samples were monitored during using standard methods. Doses 1 m−2 significantly slowed water loss until second month storage, with 17.68%...
Purpose: To determine the anti-inflammatory and anti-ulcer properties of aerial parts Centaurea tougourensis Boiss. & Reut.
 Methods: The effects n-butanol (n-BuOH) extract part on carrageenan-induced paw edema ethanol-induced gastric mucosal damage were determined at 2 doses (200 400 mg/kg, po) in a mouse model. For each test, animals randomly divided into negative positive control groups, as well extract-treated groups. mice observed for any sign inflammation period 24h.
...
Summary Introduction Traditional medicine has an important place in human history and this since antiquity. Indeed, during Egyptian Chinese civilization era, many detailed manuscripts, describing the therapeutic effect of plants, were found which suggest that folk is basis actual medicine. Objective To investigate phytochemical pharmacological properties n-butanol (n-BuOH) ethyl acetate (EA) extracts aerial part Centaurea tougourensis . Methods The evaluation was done based on HPLC-DAD...
Context: More than 500 Centaurea species compose the Asteraceae family, and most of recent studies made on this genus proved their pharmacological potential, especially to treat chronic illnesses. Aims: To evaluate for first time antioxidant, anti-inflammatory, neuroprotective anti-microbial properties n-butanol (n-BuOH) ethyl acetate (EA) extracts aerial part tougourensis. Methods: The antioxidant activity was determined by ABTS, galvinoxyl radical, phenanthroline, reducing power assays,...
Plants are considered an inestimable source of therapy, and one the oldest. The structural elucidation phytocompounds allowed scientific community to elaborate on new effective drugs, which has considerably enriched international pharmacopoeia society overcome several epidemic pandemic situations. Centaurea species demonstrated over years a remarkable capacity treat illnesses related inflammation, oxidative stress even cancer. This study aimed evaluate wound healing n-butanol (n-BuOH)...
The perennial aromatic plant Ruta tuberculata Forssk (Rutaceae) has been traditionally used by Mediterranean peoples as folk medicine against several types of disease to treat diverse illness. objective this work is evaluate the in vitro and vivo pharmacological activities aqueous (RAE) methanolic (MeOH) 80% (RME) extracts Algerian R. aerial parts. Antioxidant potential, neuro-protective anti-arthritic were investigated using six antioxidant approaches determining acetyl-cholinesterase...
Clinical pharmacology and toxicology are considered nowadays two complementary indispensable medical disciplines that allowed clinicians to achieve the optimal therapeutic effect of a several substance, but also characterize their toxicity threshold. The contribution bioinformatics tools databases in these fields has provided key elements, sometimes impossible explain during early clinical phases. In this context, some computational approaches were used work investigate molecular weight...
Centaurea species are widely used in traditional medicine to treat several illnesses, especially by Mediterranean populations due their pharmacological properties. The present study aimed evaluate for the first time some vivo activities of n-butanol (n-BuOH) extract aerial part tougourensis. For this approach; antidiabetic (streptozotocin-induced diabetes), hepatoprotective (paracetamol induced hepatotoxicity), anti-inflammatory (croton oil ear edema assay) and antipyretic plant were tested....
Among the Mediterranean aromatic plants, Ruta tuberculata Forssk. (Rutaceae) has been widely used as a traditional natural remedy against various disorders resulting from its divers’ pharmacological virtues. The aim of this study is to characterize for first time phenolic profile ethyl acetate (EtOAcE) and acetonic (AcE) extracts screen their in vitro antioxidant, antidiabetic, neuroprotective activities. Phenolic content was determined using spectrophotometric cLC-DAD analysis....
Bioinformatics as a newly emerging discipline is considered nowadays reference to characterize the physicochemical and pharmacological properties of actual biocompounds contained in plants, which has helped pharmaceutical industry lot drug development process. In this study, bioinformatics approach known silico was performed predict, for first time, properties, ADMET profile, capacities, cytotoxicity, nervous system macromolecular targets, well gene expression profiles, four compounds...
The date palm (Phoenix dactylifera L.) is one of the most important crops in arid and semi-arid zones. Date fruit occupies a good place traditional medicine among Saharan residents, due to its therapeutic virtues; although there may be several virtues yet discovered. aim this study was investigate phytochemical pharmacological properties hexanic (EHx), chloroformic (ECh), ethyl acetate (EAc) aqueous (EAq) extracts Tanteboucht pulp. characterization estimation phenolic compounds were done...
Nowadays, phyto-medicine is considered the best form of modern, scientific herbal medicine, relying on research and highest professional standards to find effective remedies for diseases including diabetes, since this disease principally linked impaired insulin function. The work aimed evaluate inhibitory capacity Moringa oleifera LAM (MEMO) (Moringaceae). Methanol extract plant was prepared delivered rats revealed a remarkable decrease in glycaemia state (vs. Glibenclamide, 5 mg/kg). Noting...
Abstract Nowadays, the physiopathological and molecular mechanisms of multiple diseases have been identified, thus helping scientists to provide a clear answer, especially those ambiguities related chronic illnesses. This has accomplished in part through contribution key discipline known as bioinformatics. In this study, bioinformatics approach was applied on four compounds identified Centaurea tougourensis , using two axes research: an silico study predict characteristics, medicinal...
Since antiquity, phytomedicine played a crucial role and many comprehensive texts documenting the medicinal impact of plants were discovered during civilization eras, suggesting folk medicine is foundation modern medicine. This work look into phytochemical composition, as well pharmacological properties, Tamarix Africana stems organic fractions. The study was carried out using screening method while phenolic, flavonoids, condensed hydrolysable tannins contents by spectrophotometric approach....
Date fruit is a functional food endowed with several pharmacological properties resulting from its diversified composition of nutrients and secondary metabolites. It often stored for long periods after harvest; however initial nutritional organoleptic are not always preserved. This study aimed to test the effect three doses γ radiations (0.6, 1.3, 2 kGy) on some Deglet Nour Ghars dates during ten months. pH, titratable acidity, contents total polyphenols, flavonoids ascorbate as well...