A5069946213- Pharmacological Effects of Natural Compounds
- Nanoparticles: synthesis and applications
- Cholinesterase and Neurodegenerative Diseases
- Liver Disease Diagnosis and Treatment
- Medicinal Plants and Neuroprotection
- Moringa oleifera research and applications
- Air Quality and Health Impacts
- Heavy Metal Exposure and Toxicity
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis C virus research
- Natural Antidiabetic Agents Studies
- Carcinogens and Genotoxicity Assessment
- Click Chemistry and Applications
- Tea Polyphenols and Effects
- Hepatitis B Virus Studies
- Free Radicals and Antioxidants
- Neurological Disorders and Treatments
- Pesticide Exposure and Toxicity
- Salmonella and Campylobacter epidemiology
- Plant biochemistry and biosynthesis
- Natural product bioactivities and synthesis
- Synthesis and pharmacology of benzodiazepine derivatives
- Vitamin D Research Studies
- Bacterial biofilms and quorum sensing
- Diet and metabolism studies
Shaqra University
2018-2024
Hydroxytyrosol (HYT) is one of the main alcoholic compounds olive leaves extract (OLE), which known for its beneficial effects. This study aimed to investigate effectiveness standardized with 25% hydroxytyrosol (OLES-25%HYT) in treatment induced ulcerative colitis. Three groups albino rats, were divided as following, group 1 (normal control), 2 (induced colitis and untreated) 3 treated OLES-25%HYT). Colonic tissue samples collected from all studied groups, antioxidant activity...
Surface-growing antibiotic-resistant pathogenic bacteria such as Escherichia coli and Staphylococcus aureus are emerging a global health challenge due to dilemmas in clinical treatment. Furthermore, their pathogenesis, including increasingly serious antimicrobial resistance biofilm formation, makes them challenging treat by conventional therapy. Therefore, the development of novel antivirulence strategies will undoubtedly provide path forward combatting these resistant bacterial infections....
In the present study, we utilized Stevia rebaudiana L. (SRLe) extract to in situ biosynthesize nanoscale alpha hematite (α-Fe2O3) nanoparticles (NPs) with potent antioxidant, antimicrobial, and anticancer properties. SRLe-α-Fe2O3 was characterized using physiochemical analyses, including UV/Vis, FTIR, XRD, DLS, EDX, SEM, TEM studies. Among tested solvents, CHCl3/MeOH (2:1 v/v) SRL (least polar solvent) contained highest EY, TPC, antioxidant capacity of ~3.5%, ~75 mg GAE/g extract, IC50 =...
inhalation of benzene vapours promote various and dangerous health problems. Fuel station workers are most susceptible to toxicity. Samples were collected twice, at beginning the study 6 months later from 40 fuel different egyptian governorates 10 control healthy volunteers. sub divided into four groups according years working in station. All them exposed exhausts during their duties, work shifts 8 hrs./day. Results indicated that; exposure induced significant increasing serum Lead Cadmium...
Oleuropein is one of the main phenolic secoiridoid olive leaf extract, which known for its antioxidant and anti-inflammatory effects. The objective present study was to investigate effectiveness oleuropein in ulcerative colitis treatment. An experimental designed on rats, were divided into three groups, group 1 (normal control), 2 (induced untreated), 3 treated with oleuropein). Colonic tissue samples collected from all studied groups oxidative stress activity assessed by evaluating...
Chronic hepatitis is major health problem that affect liver function with high morbidity and mortality in developing countries. Macerated liquorice root used since several decades as one of traditional drink Egypt. We aimed this study to evaluate the hepatoprotective effect extract versus silymarin chronic rat model explain possible mechanism hepatoprotection such disease. To achieve our aim fifty male albino rats were divided into 5 equal groups, control group, group protected extract,...
Pyrethroid esters are widely used as insecticides worldwide. In this study, we aimed to evaluate the harmful effect of deltamethrin on male reproductive system through assessment hormones, inflammatory markers, and testicular function. To achieve our aim, eighty 7-9-week-old, Wistar rats were taken, weighed, divided into four experimental groups. The first group was kept a control group, other three groups given orally at different concentrations (0.87, 8.7, 17.4 mg/kg body weight) for nine...
Discovering a cure for Alzheimer's disease remains an intricate endeavor.Acetylcholinesterase enzyme (AChE) inhibitors, such as donepezil, hold crucial position in therapy.Our present study focused on the innovative design and synthesis of new analogues employing click chemistry approach.We characterized molecular structures these synthesized compounds through combination elemental analysis various spectroscopic techniques, including FT-IR, 1 H NMR, 13 C NMR methods.These substances...
Abstract This investigation delves into the integration of Capparis spinosa extract (CSLe) onto manganese dioxide nanoparticles (MnO2NPs) and chitosan derived from honeybees (CSH) in a nanostructured configuration. The resultant nanocomposites, namely CSLe@MnO2NPs CSH/CSLe@MnO2NPs, underwent thorough characterization through various analytical techniques. UV-Vis spectroscopy unveiled distinctive features, such as ligand-to-metal charge transfer photoluminescence, affirming successful...
The cure from Alzheimer's disease is a challenging mission. Acetylcholinesterase enzyme (AChE) inhibitors, including donepezil, are considered the most important line for therapy. In current study, we aimed at designing and synthesizing new donepezil analogues through click chemistry approach. molecular structures of synthesized compounds were illustrated by spectroscopic elemental analysis FT-IR, 1H NMR, 13C NMR. These have been screened their inhibitory activity against acetyl...
Hepatitis C virus is a major cause of inflammation liver tissue. In serious cases the disease can progressed to cirrhosis, fibrosis, hepatocellular carcinoma and end stage disease. The research was designed monitoring iron, lipid profiles in hepatitis patients before during treatment with sofosbuvir antiviral drug. To achieve this aim, study conducted on 22 infection 9 control normal volunteers after taking their consent. done through biochemical determination serum ferritin, transferrin as...
Monitoring of exposure to chemical matters is seriously needed for evaluating health hazards resulted from its inhalation. The present study was carried out determine the biochemical, immunological and oxidative stress parameters as well possible histological effects benzene vapours in male albino rats. Results indicated that; Benzene induced significant increasing Myeloperoxidase (MPO) enzyme levels. This goes with marked immunologic changes presented by decreases immunoglobulins; IgA IgG,...
Kombucha tea is highly fermented beverage popularly consumed in many countries. The aim was to evaluate the possible protective effects of usage as natural agent against stressful resulted from administration high sucrose diet male rabbits through determination some biochemical parameters. results demonstrated that pretreatment with stressed rabbit significantly improve lipid profile and antioxidant system meanwhile significant reduction glucose, urea, creatinine, cupper non change...
Obesity is the most prevalent nutritional disorder. Healthy diets helps people maintain and improve their general health. This study aimed to assessment of low very calorie through determination its effect on lipid metabolism, iron profile kidney function in obese male rats. To achieve our aim forty five albino rats were used divided into 4 groups: control group, group with 75 calories diet, 60 diet 45 diet. Our result showed significant disturbance lipid, supplementation improvement or The...
Zoledronic acid is a long-acting compound of bisphosphonate class, and it has many health medical benefits, among which are its effects in treatment bone disorders accordingly decrease the incidence osteoporosis. Besides, vitamin D recognized as one fat-soluble vitamins that affect absorption major minerals digestive system. The aim this study was to verify influence on biochemical effect zoledronic acid. To achieve study, experiment conducted ninety-six male Wistar rats were divided into...