The hepatocellular carcinoma (HCC) incident rate is gradually increasing yearly despite all the research and efforts taken by scientific communities governing bodies. Approximately 90% of liver cancer cases belong to HCC. Usually, HCC patients approach treatment in late stages this malignancy which becomes primary cause high mortality rate. knowledge about molecular pathogenesis limited needs more attention from researchers identify driver genes miRNAs, causes translate information into...

Precision oncology is an absolute need today due to the emergence of treatment resistance and heterogeneity among cancerous profiles. Target-propelled cancer therapy one treasures precision which has come together with substantial medical accomplishment. Prostate most common cancers in males, tremendous biological molecular clinical behavior. The spectrum abnormalities varying patterns prostate suggest different To identify novel therapeutic targets precise biomarkers implicated cancer, we...

Background/Aims Health-impairing lifestyle during adolescence is an important marker for poor health. An unhealthy may lead to physical and psychological problems in adulthood. Most of the prior researches were done among adult population. Therefore, we assessed chronotype pattern correlation health-impairing lifestyles with sleep quality according circadian typology medical students. Material Methods In this cross-sectional research, a total 203 subjects enrolled. All divided into definite...

Acute respiratory distress syndrome (ARDS) is an outcome of accelerated immune response that starts initially as a defensive measure, however, due to non-canonical signaling, it later proves be fatal not only the affected tissue but whole organ system. microRNAs are known for playing decisive role in regulating expression genes involved diverse functions such lung development, repair, and inflammation. In-silico analyses clinical data microRNA databases predicted probable interaction between...

Striking similarity exists between metabolic changes associated with embryogenesis and tumorigenesis. Chromobox proteins-CBX2/4/6/7/8, core components of canonical polycomb repressor complex 1, play essential roles in embryonic development aberrantly expressed breast cancer. Understanding how altered CBX expression relates to reprogramming cancer may reveal vulnerabilities therapeutic pertinence. Using transcriptomic metabolomic data from patients (N > 3000 combined), we performed...

Macrophage polarization and infiltration to the tumor microenvironment (TME) is a critical determining factor for progression. Macrophages are polarized into two states—M1 (pro-inflammatory, anti-tumorigenic stimulated by LPS or IFN-γ) M2 (anti-inflammatory pro-tumorigenic IL-4) phenotypes. Specifically, macrophages enhance cell growth survival. Recent evidences suggest pivotal role of microRNAs in macrophage during development Non-small lung cancer (NSCLC), thus proposing new therapeutic...

Lung cancer is the leading cause of mortality from worldwide. adenocarcinoma (LUAD) a type non-small cell lung (NSCLC) with highest prevalence. Kinesins class motor proteins are shown to be involved in carcinogenesis. We conducted expression, stage plot and survival analyses on kinesin superfamily (KIF) scrutinized key prognostic kinesins. Genomic alterations these kinesins were studied thereafter via cBioPortal. A protein-protein interaction network (PPIN) selected 50 closest altering genes...

Head and neck squamous cell carcinoma (HNSC) is one of the most common malignant tumors worldwide with a high rate morbidity mortality, 90% predilections occurring for oral (OSCC). Cancers mouth account 40% head cancers, including carcinomas tongue, floor mouth, buccal mucosa, lips, hard soft palate, gingival. OSCC devastating commonly malignancy, mortality 500,000 deaths per year. This has imposed strong necessity to discover driver genes responsible its progression malignancy. In present...

Lung cancer has the lowest survival rate spread globally resulting in a large number of deaths. This is attributed to insufficient measures such as lack early detection and chemoresistance patients. It can be subdivided into two histological groups: Non-Small-Cell Cancer (NSCLC), which most prevalent (85% all lung cancers) but less destructive; Small-Cell (SCLC), intermittently metastatic (15% cancers). The present study deals with analysis gene expression subtypes identify Differentially...

Lung cancer is a prime cause of worldwide deaths, with non-small cell lung (NSCLC) as frequent subtype. Surgical resection, chemotherapy are the currently used treatment methods. Delayed detection, poor prognosis, tumor heterogeneity, and chemoresistance make them relatively ineffective. Genomic medicine budding aspect therapeutics, where miRNAs impressively involved. short ncRNAs that bind to 3'UTR target mRNA, causing its degradation or translational repression regulate gene expression....

Buprenorphine is a semi-synthetic derivative of thebaine; its low concentration sufficient to provide effective pain relief.To evaluate the efficacy transdermal buprenorphine patch in postoperative management.After ethical approval and taking informed consent from patients, they were randomized into three groups (n=30 each group) using computer generated random number table. Group A: placebo patch; B: (10mg) C: (20mg) patch. Haemodynamic analgesic effects compared by analysis variance...

The hepatitis E virus (HEV) is a long-ignored that has spread globally with time. It ranked 6th among the top risk-ranking viruses high zoonotic spillover potential; thus, considering its viral threats pressing priority. molecular pathophysiology of HEV infection or underlying cause limited. Therefore, we incorporated an unbiased, systematic methodology to get insights into biological heterogeneity associated HEV. Our study fetched 93 and 2016 differentially expressed genes (DEGs) from...

Abstract COVID‐19 is a sneaking deadly disease caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). The rapid increase in the number of infected patients worldwide enhances exigency for medicines. However, precise therapeutic drugs are not available COVID‐19; thus, exhaustive research critically required to unscramble pathogenic tools and probable targets development effective therapy. This study utilizes chemogenomics strategy, including computational identification...

Abstract Sepsis has affected millions of populations all age groups, locations, and sexes worldwide. Immune systems, either innate or adaptive are dysregulated due to the infection. Various biomarkers present date, still sepsis is a primary cause mortality. Globally, post-operative body infections can septic shock in ICU. Abnormal antigen presentation T-cells leads immune system. miRNAs sparkly evolved as their high sensitivity efficiency. In this work, we analyzed high-throughput mRNA data...

Abstract Background Hepatocellular carcinoma (HCC) is the most common primary liver cancer. It has sixth incident cases with poor prognosis. Adipokines are known to have been linked oncogenesis and progression of HCC. Methods We extracted TCGA-HCC data identified differentially expressed genes (DEGs) using R. Genes adipokines adipogenesis family were scrutinized from DEGs expression in normal versus tumor patients was studied. Prognostic stage plot analyses performed, key selected. Pathway...

Extensive metabolic heterogeneity in breast cancers has limited the deployment of therapies. To enable patient stratification, we studied landscape (∼3000 patients combined) and identified three subtypes with increasing degrees deregulation. Subtype M1 was found to be dependent on bile-acid biosynthesis, whereas M2 showed reliance methionine pathway, M3 engaged fatty-acid, nucleotide, glucose metabolism. The extent alterations correlated strongly tumor aggressiveness outcome. This pattern...

Interleukin-18 (IL-18) is one of the immunomodulatory cytokines that plays an important role in cellular functions against tumor development and progression. IL-18 (-607) C/A (-0137) G/C gene promoter polymorphisms their haplotypes variants are associated with risk various cancers. We evaluated a possible association (-137) susceptibility to oral squamous cell carcinoma (OSCC). A total number 272 patients OSCC 185 healthy volunteers were genotyped for polymorphism. Polymorphism examined by...