A5024785322- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Nausea and vomiting management
- HIV/AIDS drug development and treatment
- Tuberculosis Research and Epidemiology
- Oral and gingival health research
- Anesthesia and Neurotoxicity Research
- Oxidative Organic Chemistry Reactions
- Biochemical and Molecular Research
- Oral Health Pathology and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Immune Response and Inflammation
- Adenosine and Purinergic Signaling
- Fluorine in Organic Chemistry
- Airway Management and Intubation Techniques
- Photochromic and Fluorescence Chemistry
- Soil Moisture and Remote Sensing
- Luminescence and Fluorescent Materials
- Asymmetric Synthesis and Catalysis
- Dental Anxiety and Anesthesia Techniques
- NF-κB Signaling Pathways
- Pain Management and Opioid Use
- Drug-Induced Adverse Reactions
- Synthesis and Biological Evaluation
- Geophysical Methods and Applications
Central University of South Bihar
2015-2024
Amrita Vishwa Vidyapeetham
2024
Seoul National University
2015-2023
King George's Medical University
2009-2019
M.S. Ramaiah Medical College
2014-2018
Post Graduate Institute of Medical Education and Research
2017
Bangalore Medical College and Research Institute
2017
Ewha Womans University
2010-2014
Indian Institute of Horticultural Research
2013
Ewha Womans University Medical Center
2012
Objectives: To evaluate and compare the efficacy safety of Intranasal (IN) Dexmedetomidine, Midazolam Ketamine in producing moderate sedation among uncooperative pediatric dental patients. Study Design: This randomized triple blind comparative study comprises eighty four ASA grade I children both sexes aged 4-14 years, who were could not be managed by conventional behavior management techniques. All to receive one drug groups Dexmedetomidine 1?g/ kg (D1), 1.5μg/kg (D2), 0.2mg/kg (M1) 5mg/kg...
For treatment of intra and postoperative pain, no drug has yet been identified that specifically inhibits nociception without associated side effects. Magnesium antinociceptive effects in animal human models pain. The current prospective randomised double-blind study was undertaken to establish the effect addition magnesium or clonidine, as adjuvant, epidural bupivacaine lower abdominal limb surgeries. A total 90 American Society Anesthesiology (ASA) grade I II patients undergoing surgeries...
On the basis of potent biological activity cyclopentenyl-pyrimidines, fluorocyclopentenyl-pyrimidines were designed and synthesized from d-ribose. Among these, cytosine derivative 5a showed highly antigrowth effects in a broad range tumor cell lines very antitumor nude mouse xenograft model implanted with A549 human lung cancer cells. However, its 2′-deoxycytidine 5b did not show any effects, indicating that 2′-hydroxyl group is essential for activity.
Fibroadenoma is a generally common benign, non-cancerous lump that appears suddenly and can be very difficult to distinguish from cancer. The exact cause of fibroadenomas unknown. About 10% women worldwide are estimated experience it once in their lifetime. It affect female at any age, even though more the age group 20–30. In this case report, we presented 29-year-old patient who had huge fibroadenoma her left breast, measuring 10 × 8 cm. underwent lumpectomy was recovering well. general,...
Abstract Hydroxy azo‐benzenes are very well known for their rapid trans ⇆ cis photoisomerization under polar solvents. In contrast, we synthesized two hydroxymethylated‐ hydroxyazobenzene derivatives and investigated light‐triggered stability The result showed just opposite behavior slow isomerization was observed (minutes‐days). Thus, the UV‐vis spectrum revealed a low decrease in absorbance of π–π* transition. Surprisingly, process became faster with addition ionic species. Here, attempted...
Objective: The objective of this study was to compare and evaluate the efficacy safety drops atomized administration intranasal ketamine (INK) in terms behavioral response for agent acceptance during sedation young uncooperative pediatric dental patients. Study design: Thirty Four ASA grade-1 children, requiring treatment were randomly assigned receive INK as spray one subsequent visit. This a two stage cross-over trial each child received by both modes administration. vital signs monitored...
Truncated N(6)-substituted-4'-oxo- and 4'-thioadenosine derivatives with C2 or C8 substitution were studied as dual acting A(2A) A(3) adenosine receptor (AR) ligands. The lithiation-mediated stannyl transfer palladium-catalyzed cross-coupling reactions utilized for functionalization of the position 6-chloropurine nucleosides. An unsubstituted 6-amino group a hydrophobic substituent required high affinity at hA(2A)AR, but abolished binding hA(2A)AR. However, most synthesized compounds...
Summary Background Use of sedative agents for difficult to manage children during dental procedures has been indicated years, but neither the agent nor route found be ideal. Objectives The aim study was evaluate and compare efficacy safety oral dexmedetomidine (D) ketamine (K) in producing moderate sedation among uncooperative pediatric patients. Methods This prospective, triple‐blind, randomized comparative included 112 ASA grade I both sexes aged 3–10 who satisfied all inclusion criteria....
On the basis of potent inhibitory activity neplanocin A (1) against S-adenosylhomocysteine (AdoHcy) hydrolase, we analyzed comprehensive structure-activity relationships by modifying adenine and carbasugar moiety 1 to find pharmacophore in active site enzyme. The introduction 7-deazaadenine instead eliminated AdoHcy while 3-deazaadenine maintained enzyme, indicating that N-7 is essential for its role as a hydrogen bonding acceptor. substitution at 6'-position with fluorine increased...
Postoperative pain after thoracotomy is being considered one of the most severe and if not treated well, can result in various respiratory other complications.Present study was conducted with aim to compare continuous thoracic epidural infusion paravertebral for postoperative using Visual Analogue Scale (VAS) score four point observer ranking. The secondary outcomes measured were pulmonary functions any complication like hypotension, bradycardia, nausea, vomiting, urinary retention...
The first synthesis of 4′-selenothymidine (1), a novel DNA building block, and 4′-seleno-AZT (2) was accomplished from 2-deoxy-d-ribose via stereoselective formation 2-deoxy-4-seleno-d-furanose 17 Pummerer-type base condensation as key steps. 4′-Selenothymidine (1) discovered to adopt the same 2′-endo/3′-exo conformation thymidine, which is unusual in that 4′-selenouridine has opposite uridine.
Introduction: In 2007, Ministry of Women and Child Welfare, supported by United Nations Children's Fund, save the children Prayas conducted a study to understand magnitude child abuse in India, they found that 53.22% faced one or more forms sexual abuse; among them, number boys abused was 52.94%. Aim: The aim this explore barriers for seeking psychiatric help qualitative analysis stake holders male victims abuse. Materials Methods: All statements made stakeholders regarding assessment...
Background: The pro-inflammatory cytokines play an essential role in immune response and are involved a variety of inflammatory infectious disease. Tumor necrosis factor alpha (TNF-α) gene polymorphism has been potential determinant susce
Truncated N(6)-substituted-(N)-methanocarba-adenosine derivatives with 2-hexynyl substitution were synthesized to examine parallels corresponding 4'-thioadenosines. Hydrophobic N(6) and/or C2 substituents tolerated in A3AR binding, but only an unsubstituted 6-amino group a C2-hexynyl promoted high hA2AAR affinity. A small hydrophobic alkyl (4b and 4c) or N(6)-cycloalkyl (4d) showed excellent binding affinity at the hA3AR was better than free amino (4a). affinities of 3-halobenzylamine 4f-4i...