A5062455082- RNA modifications and cancer
- Prostate Cancer Treatment and Research
- RNA and protein synthesis mechanisms
- Pregnancy and preeclampsia studies
- SARS-CoV-2 and COVID-19 Research
- Advanced Breast Cancer Therapies
- Cancer-related molecular mechanisms research
- Estrogen and related hormone effects
- Gestational Diabetes Research and Management
- Data-Driven Disease Surveillance
- COVID-19 diagnosis using AI
- Renal and related cancers
- ATP Synthase and ATPases Research
- Biological Research and Disease Studies
- Science and Climate Studies
- Birth, Development, and Health
- Philosophy and History of Science
- Long-Term Effects of COVID-19
- Ion Transport and Channel Regulation
- Pharmacogenetics and Drug Metabolism
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Energy and Environment Impacts
- Opioid Use Disorder Treatment
All India Institute of Medical Sciences
2022-2024
Indian Council of Medical Research
2022-2023
St. James's Hospital
2023
Trinity College Dublin
2023
Institute of Medical Sciences
2023
Next-generation sequencing (NGS) has transformed high-throughput DNA and RNA analysis, facilitating the rapid identification of clinically relevant genetic variants. Opioid Use Disorder (OUD), a chronic condition characterized by relapse remission cycles, poses significant challenges for genomic investigations. While whole-exome (WES) whole genome (WGS) serve as robust approaches variant detection, their high cost restricts widespread use. (RNA-Seq) presents viable alternative; however,...
The Androgen Receptor (AR) has emerged as an endocrine therapy target in Breast Cancer, exhibiting up to 80% expression clinical cases. AR-V7, a constitutively activated splice variant of AR with truncated ligand-binding domain (LBD), demonstrates ligand-independent transcriptional activity and resistance nonsteroidal antiandrogens like Bicalutamide or Enzalutamide, targeting the LBD. In metastatic prostate cancer, elevated AR-V7 levels lead therapeutic increased metastasis. this study, we...
<title>Abstract</title> Background: The Androgen Receptor (AR) has emerged as an endocrine therapy target in Breast Cancer, exhibiting up to 80% expression clinical cases. AR-V7, a constitutively activated splice variant of AR with truncated ligand-binding domain (LBD), demonstrates ligand-independent transcriptional activity and resistance nonsteroidal antiandrogens like Bicalutamide or Enzalutamide, targeting the LBD. In metastatic prostate cancer, elevated AR-V7 levels lead therapeutic...
Most viruses–including SARS-CoV-2, seem to have evolved over time. The lack of stringent proofreading mechanisms makes viral DNA/RNA replication error-prone. When a virus replicates, it sometimes changes little bit, which is called mutations. Any with one or more new mutations can be referred as “variant” the original virus. last 2 years witnessed emergence large number variants. Since pandemic’s beginning, SARS-CoV-2 coronavirus has mutated extensively, resulting in different variants One...
<title>Abstract</title> tsRNAs(tRNA derived small non-coding RNAs), including tRNA halves (tiRNAs), and fragments (tRFs) have been implicated in some viral infections like respiratory infections. However, their involvement SARS-CoV infection is completely unknown. The objective of this study to determine tsRNAs level a mouse infected with wild-type, attenuated, mock-infected strains. Gene Expression Omnibus (GEO) dataset at NCBI accession ID GSE90624 was used for study. After count matrix...
Most viruses–including SARS-CoV-2, seem to have evolved over time. The lack of stringent proofreading mechanisms makes viral DNA/RNA replication error-prone. When a virus replicates, it sometimes changes little bit, which is called mutations. Any with one or more new mutations can be referred as “variant” the original virus. last 2 years witnessed emergence large number variants. Since pandemic’s beginning, SARS-CoV-2 coronavirus has mutated extensively, resulting in different variants One...