Neutrophils (PMNs) and cytokines have a critical role to play in host defense systemic inflammatory response syndrome (SIRS). Neutrophil extracellular traps (NETs) been shown extracellularly kill pathogens, potential of NETs has shown. Microbial killing inside the phagosomes or by is mediated reactive oxygen nitrogen species (ROS/RNS). The present study was undertaken assess circulating contents frequency generation isolated PMNs from SIRS patients. These patients displayed significant...

Abstract Background Bloodstream infections (BSIs) are an emerging cause of significant morbidity and mortality in severe Coronavirus disease 2019 (COVID-19). We aimed to assess the prevalence, clinical profile outcome BSIs critically ill COVID-19 patients. Methods This was a single-centre retrospective study conducted at tertiary care hospital Western India. All patients (age > 18 years) with reverse-transcription polymerase chain reaction (RT-PCR) confirmed admitted intensive unit (ICU)...

This study aimed to assess the influence of early administration methylene blue (MB) and vasopressin on dose noradrenaline required manage septic shock. was a parallel, randomized, controlled trial including 74 adult patients with shock admitted intensive care unit (ICU). Once requirement exceeded 0.2 µg/kg/min, were randomly allotted group M V. Group received an intravenous 1 mg/kg bolus MB over 30 minutes, then infusion 0.5 6 hours. V at rate 0.04 units/min for The primary outcome this...

Background: Acute hypoxemic respiratory failure is among the more commonly occurring complications in postoperative patients.Supplemental oxygen and addressing primary etiology form basis of its treatment. Materials methods:We conducted an open-labeled randomized control trial with 90 adult patients compared three delivery vehicles (ODV), i.e., noninvasive ventilation (NIV), high-flow nasal cannula (HFNC), venturi mask (VM) patients.The outcome variable was a change P/F ratio after 2 hours...

Although the efficacy of high-flow nasal oxygen therapy in delaying or avoiding intubation patients with hypoxemic respiratory failure has been studied, its potential for facilitating early weaning from invasive mechanical ventilation remains unexplored. In this randomized controlled trial, 80 adults acute requiring > 48 hours were enrolled and divided into two groups: conventional via oxygen. group, spontaneous breathing trial was performed after PaO2/FiO2 ratio ≥ 200, whereas conducted...

Abstract Background Candidemia has become one of the commonest nosocomial blood stream infection (BSI) secondary to infected central venous catheters or surgical site infections. Prompt diagnosis followed by early treatment is needed reduce high mortality associated with it. Hence this study was conducted analyse epidemiology, clinical characteristics, species distribution, resistance profile, outcome and factors related in candidemia. Methods It a retrospective observational analysis done...

Abstract Background Pseudomonas aeruginosa is a leading pathogen causing widespread hospital acquired infections worldwide. As WHO has also designated Carbapenem resistant as one of three Critical Priority Pathogen, we decided to conduct study on the isolates find out presence carbapenemase genes using RT-PCR and relation between phenotypic assessment carbapenem resistance with genotypic detection genes. Methods Total 41 patients were included in this prospective observational done for 6...

Purpose The aim of this study is to identify Clostridioides difficile associated diarrhoea (CDAD) in patients admitted acute care units the hospital. It also examines different detection methods, including anaerobic culture, GDH assay, and Toxin A/B ELISA, while exploring how infection relates patient risk factors clinical features. Materials Method Cross sectional conducted Department microbiology over 2 years. Patients >1 year age, who were passing atleast 3 unformed stool 24 hours,...

Sonia M, Kaur S, Kothari N. Author Response: The Range of Nonpharmacological Measures to Prevent Delirium on Intensive Care Units is Broader than Assumed. Indian J Crit Med 2025;29(3):280-281.

Sepsis stands as a significant contributor to mortality in ICU settings worldwide. Early diagnosis and appropriate treatment are therefore essential reduce mortality. We planned this study investigate the diagnostic significance of prokineticin-2 (PK-2) patients with sepsis. Adult sepsis who were admitted our intensive care unit (ICU) included prospective observational study. On day admission 7th stay, levels procalcitonin (PCT) PK-2 assessed. Patients' was observed for 28 days. This...

Abstract Despite extensive work done in the field of sepsis biomarkers; still, there is no consensus on which parameter could be considered as an ideal biomarker for diagnosis. This review aims to look into existing biomarkers clinical utility are currently being used diagnostics along with their advantages and disadvantages. We also provide insight usefulness a multi-marker approach diagnosing what future direction. A literature was conducted four search engines such PubMed, Scopus, Google...

Objective: COVID-19 has emerged as a multi-system disease with the potential for endocrine dysfunction. We aimed to study hormonal profile of hospitalized patients at tertiary care referral hospital Jodhpur, India. Design: A hospital-based clinical conducted from 15 th May 30 June 2020 after ethical approval. Measurements: Fasting blood samples free thyroxine (T4), tri-iodothyronine (T3), thyroid stimulating Hormone (TSH), serum prolactin; basal and 1 h post-intramuscular adrenocorticotropic...

Carbapenem-resistant Enterobacterales (CRE) are a global health problem with growing prevalence. India has high prevalence of CRE. CRE infections difficult to treat, and associated significant morbidity mortality. Colonisation is generally prerequisite for infection the prevention colonisation key infection.To determine subsequent in an adult intensive care unit (ICU) India.We conducted prospective observational study which perirectal swabs were obtained along relevant clinical details...

Aims and Context: The objective of the present study was to evaluate analgesic adverse effects intrathecal clonidine with hyperbaric bupivacaine in spinal anesthesia. Settings Design : Randomized single blind trial. Methods: 210 ASA I-II pregnant females undergoing emergency cesarean section were randomized a single-blind fashion one three groups. In group I (n=70) patients received 12.5 mg 0.5% intrathecally. II mixture (8 mg) 50 μg. III , (10 intrathecally along μg clonidine. Statistical...

Purpose: To compare norepinephrine and terlipressin vs alone for management of septic shock.Materials methods: In this prospective, randomized control trial, 50 adult patients with shock were into two groups.Group I received a combination injection 0.02 µg/kg/min (fixed dose) infusion 0.01 group II alone.Dose noradrenaline in both the groups was titrated to achieve target MAP 65-70 mm Hg.The data collected dose required maintain an above 65 Hg, urine output, serum lactate, procalcitonin...

Purpose: Nosocomial bloodstream infections with multidrug-resistant microorganisms have become a common health threat in intensive care settings worldwide. Understanding antimicrobial resistance and the outcomes of these is crucial for addressing this issue. This study aimed to investigate burden, resistance, 28-day nosocomial unit. Materials Methods: retrospective was conducted multispecialty unit at tertiary hospital western India. Adult patients aged ≥18 years acquired after 48 h...

Delirium is a syndrome commonly seen in intensive care unit (ICU) patients. It characterized by acute changes mental status, inattention, disorganized thinking, and altered level of consciousness. Due to its higher prevalence mechanically ventilated ICU patients, it crucial recognize early implement standardized evidence-based protocols for preventing regular practice. To identify the benefits effectiveness nonpharmacological interventions delirium among critically ill patients admitted ICU....

This study examined the role of interleukin (IL)-1 receptor-associated kinase (IRAK) and protein C (PKC) in oxidized LDL (Ox-LDL)-induced monocyte IL-1β production. In THP1 cells, Ox-LDL induced time-dependent secretory IRAK1 activity; IRAK4, IRAK3, CD36 expression; PKCδ-JNK1 phosphorylation; AP-1 activation. IRAK1/4 siRNA inhibitor (INH)-attenuated secreted pro-IL-1β mRNA mature expression, respectively. Diphenyleneiodonium chloride (NADPH oxidase INH) N-acetylcysteine (free radical...

Hypokalemic periodic paralysis is a rare genetic disorder characterized by recurrent attacks of skeletal muscle weakness with associated hypokalemia which precipitated stress, cold, carbohydrate load, infection, glucose infusion, hypothermia, metabolic alkalosis, anesthesia, and steroids. We encountered one such incidence prolonged recovery after general on further evaluation revealed case hypokalemic paralysis. The key to successful management patient was vigilant pre-operative evaluation,...

Post-spinal anesthesia hypotension is of common occurrence, and it hampers tissue perfusion. Several preoperative factors determine patient susceptibility to hypotension. This study aimed assess the effectiveness Inferior Vena Cava Collapsibility Index (IVCCI) for predicting intraoperative hypotension.One hundred twenty-nine adult patients who were scheduled elective surgical procedures after administration spinal (intrathecal) included in study. Ultrasound evaluation (IVC) was done area,...

Tracheostomy is a weaning technique in patients requiring prolonged ventilation. During this period, complications like tube blockage, fracture of the tracheostomy tube, or cuff rupture can occur. Fracture result distal end being dislodged further down trachea, leading to airway obstruction and hypoxia. We report which was removed, using inflation line pilot balloon pull out broken tube.