A5101593731- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Malaria Research and Control
- Hepatitis Viruses Studies and Epidemiology
- Monoclonal and Polyclonal Antibodies Research
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Zoonotic diseases and public health
- COVID-19 Clinical Research Studies
- Viral Infections and Outbreaks Research
- Congenital Heart Disease Studies
- SARS-CoV-2 and COVID-19 Research
- Systemic Lupus Erythematosus Research
- Viral gastroenteritis research and epidemiology
- Virology and Viral Diseases
- interferon and immune responses
- Animal Virus Infections Studies
- vaccines and immunoinformatics approaches
- Helicobacter pylori-related gastroenterology studies
- Influenza Virus Research Studies
- IoT and Edge/Fog Computing
- Hematopoietic Stem Cell Transplantation
Centre of Excellence in Molecular Biology
2015-2025
University of the Punjab
2016-2025
COMSATS University Islamabad
2024
University of Swabi
2021-2024
University of Peshawar
2017-2024
University of Health Sciences Lahore
2022-2024
University Hospitals of Cleveland
2024
Beaumont Hospital
2024
University of Agriculture Faisalabad
2023
Hayatabad Medical Complex
2021-2023
Information regarding hepatitis C virus genotypes and subtypes circulating in Pakistan various risk factors for their transmission are not known well. The specific objective of this study was to find out the frequency HCV present well-characterized Pakistani isolates possible routes transmission. A total 3351 serum samples were tested by type-specific genotyping assay. Out RNA positive patients, 2039 males 1312 females. As regard as genotyped samples, 2165 belonged Punjab region, 823...
The Marburg virus (MARV) has a negative-sense single-stranded RNA genome, belongs to the family Filoviridae, and is responsible for several outbreaks of highly fatal hemorrhagic fever. Codon usage patterns viruses reflect series evolutionary changes that enable shape their survival rates fitness toward external environment and, most importantly, hosts. To understand evolution MARV at codon level, we report comprehensive analysis synonymous in genomes. Multiple approaches statistical methods...
Since the first reported outbreak of dengue hemorrhagic fever in Pakistan, several mini outbreaks have erupted region. Dengue virus serotype 3 (DEN-3) was documented 2005 Karachi. Reports show that is prevalent Lahore since 2008. Serotype 2 (DEN-2) major circulating Pakistan as it 1994. We conducted a detailed study three infection occurred years 2007, 2008 and 2009 by using molecular techniques such PCR nucleotide sequencing C-prM gene junction virus.Through analysis 114 serum samples...
To estimate the prevalence and spectrum of hepatitis C virus (HCV) infection in general population Pakistan.A total 6817 blood samples were collected randomly from apparently healthy people Punjab, Pakistan March 1999 to April 2001 September 2006 August 2007. Detailed socioeconomic information for each participant was recorded. All tested anti-HCV antibodies all seropositive further HCV RNA by polymerase chain reaction (PCR).Of serum tested, 998 (14.63%) positive antibodies. PCR detected 494...
AIM:To assess the association between chronic hepatitis C virus (HCV) infection and hepatocellular carcinoma (HCC) in Pakistan, genotype distribution among these HCC patients. METHODS:One hundred sixty-one subjects with were included this study.Liver biopsy was performed on 145 of patients; sixteen excluded because they failed to fulfill inclusion criteria.Qualitative polymerase chain reaction (PCR) for B HCV.Samples positive HCV RNA genotyped using genotypespecific PCR confirmed by 5'...
The aim of this study was to determine the rate sustained virological response (SVR) and various factors associated with rates in chronic hepatitis C infected patients treated interferon alpha ribavirin combination therapy. A retrospective review data collected at Centre from 2001 2007 performed. Out 731 consecutive 400 that fulfilled criteria were evaluated subsequently a 2b (3 MU subcutaneously three injections weekly) (800–1200 mg orally daily). Treatment administered for either 24 weeks...
Abstract Background H9N2 avian influenza A viruses have become panzootic in Eurasia over the last decade and caused several human infections Asia since 1998. To study their evolution zoonotic potential, we conducted an silico analysis of that infected humans between 1997 2009 identified potential novel reassortments. Results total 22 hemagglutinin (HA) neuraminidase (NA) nucleotide deduced amino acid sequences were retrieved from NCBI flu database. It was mature peptide HA genes isolated had...
Cloud Computing (CC) is a promising technology due to its pervasive features, such as online storage, high scalability, and seamless accessibility, in that it plays an important role reduction of the capital cost workforce, which attracts organizations conduct their businesses financial activities over cloud. Even though CC great innovation aspect computing with ease access, also has some drawbacks. With increase cloud usage, security issues are proportional increase. To address these, there...
Six major Hepatitis C virus (HCV) genotypes and hundreds of subtypes have been identified globally. All these are generally studied for epidemiology, their vaccine development clinical management. This article comments the frequency distribution various HCV circulate in different areas/districts Khyber Pakhtoonkhaw Province Pakistan. Sum 415 RNA PCR positive sera samples were tested by a molecular genotyping assay. Data analysis revealed that out patients 243 males 172 females. Distribution...
Abstract Hepatitis C Virus (HCV) genotype and viral load are two significant predictive variables knowledge of which might persuade treatment decisions. The objective the present study was to identify distribution different HCV genotypes circulating in area estimate chronically infected patients. Out total 305 positive patients, 177 (58%) were males 128 (42%) females. Frequency breakup patients 169, 69, 38 29 from Abbottabad, Mansehra, Haripur Battagram districts respectively. tested serum...
Dengue is the most important vector-borne disease in many different parts of world and expanding into other areas globe without hindrance. The morbidity mortality due to dengue complications are increasing globally at an alarming rate. Although transmission virus has been documented well-characterized Pakistan, its incidence Khyber Pakhtunkhawa not characterized. To address this issue we aimed determine seroprevalence (IgM IgG) antibodies symptoms population Pakhtunkhawa, investigate fever...
Emerging infectious diseases pose a serious threat to public health security; this is especially true in the underdeveloped world because of limited resources combat them. These emerging pathogens are characterized by novel mode pathogenesis and, some cases, broad host range. Over past few decades, Pakistan has suffered great deal from such as dengue, Crimean-Congo fever, hepatitis, measles, and polio. Changing climate conditions, environmental degradation, global warming, loss biodiversity,...
Cytokines are crucial in controlling inflammation during viral infection, particularly infection with the hepatitis C virus (HCV). Cytokine genetic polymorphisms can change how immune system responds to this infection. We investigated HCV treatment was affected by single nucleotide these genes. The goal of study examine any connections between cytokine gene for interleukins (IL)-22-binding protein rs6570136, as well IL-10 rs1800872 and rs1878672 Pakistani population responsiveness...