A5060436489- Histone Deacetylase Inhibitors Research
- Immune Cell Function and Interaction
- Adenosine and Purinergic Signaling
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- NF-κB Signaling Pathways
- Phagocytosis and Immune Regulation
- Cytokine Signaling Pathways and Interactions
- Bioactive Compounds and Antitumor Agents
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Neuroblastoma Research and Treatments
- Immune Response and Inflammation
- Acute Myeloid Leukemia Research
- Sesquiterpenes and Asteraceae Studies
- RNA modifications and cancer
- Antimicrobial Peptides and Activities
University of California, San Diego
2021-2023
COMSATS University Islamabad
2021-2022
Abstract Pancreatic ductal adenocarcinoma (PDAC) is an insidious disease with a low 5-year survival rate. PDAC characterized by infiltration of abundant tumor-associated macrophages (TAM), which promote immune tolerance and immunotherapeutic resistance. Here we report that macrophage spleen tyrosine kinase (Syk) promotes growth metastasis. In orthotopic mouse models, genetic deletion myeloid Syk reprogrammed into immunostimulatory phenotype, increased the infiltration, proliferation,...
The reprogramming of energy metabolism is one the hallmarks cancer and crucial for tumor progression. Altered aerobic glycolysis a well-known characteristic cell metabolism. In present study, expression profiles key metabolic genes (HK2, PFKM, PKM2) were assessed in breast cohort Pakistan using quantitative polymerase chain reaction (qPCR) IHC. Expression patterns correlated with molecular subtypes clinical parameters patients. A significant upregulation glycolytic was observed samples...
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MDSCs are immune cells of myeloid lineage that plays a key role in promoting tumor growth. The expansion tumor-bearing hosts reduces the efficacy checkpoint inhibitors and CAR-T therapies, hence strategies deplete or block recruitment have shown benefit improving responses to immunotherapy various cancers, including NB. Ibrutinib, an irreversible molecular inhibitor BTK, has been widely studied B cell malignancies, recently, this drug is repurposed for treatment solid tumors. Herein we...
The epithelial cell adhesion molecule (EpCAM) is considered an essential proliferation signature in cancer. In the current research study, qPCR induced expression of EpCAM was noted acute lymphoblastic leukemia (ALL) cases. Costunolide, a sesquiterpene lactone found crepe ginger and lettuce, medicinal herb with anticancer properties. Expression its downstream target genes (Myc TERT) wasdownregulated upon treatment costunolide Jurkat cells. A significant change telomere length cells not at 72...
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