A5017243514- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood groups and transfusion
- Heparin-Induced Thrombocytopenia and Thrombosis
- Chronic Myeloid Leukemia Treatments
- Lymphoma Diagnosis and Treatment
- Platelet Disorders and Treatments
- Acute Myeloid Leukemia Research
- Peripheral Neuropathies and Disorders
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- COVID-19 Impact on Reproduction
- Fungal Plant Pathogen Control
- SARS-CoV-2 and COVID-19 Research
- CNS Lymphoma Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Trace Elements in Health
- Neutropenia and Cancer Infections
- Chronic Lymphocytic Leukemia Research
- Infectious Diseases and Mycology
- COVID-19 and healthcare impacts
- Hemophilia Treatment and Research
- Hematopoietic Stem Cell Transplantation
- Parasitic Infections and Diagnostics
King Abdulaziz University
2021-2024
King Fahad Hospital Jeddah
2023
University of Jeddah
2023
King Abdul Aziz University Hospital
2021-2022
Université Clermont Auvergne
2017-2019
Centre Hospitalier Universitaire de Clermont-Ferrand
2019
Vincristine therapy can be effective in refractory Immune thrombocytopenia (ITP) following COVID-19 vaccination. Our case report highlights the need for further research to establish standard management guidelines COVID-19-vaccine-associated ITP.
Background: Iron deficiency anemia (IDA) is a global health problem affecting the quality of life more than 2 billion individuals. The current practice guidelines diagnose and monitor IDA via conventional hematological iron biomarkers, which take several months before they are corrected under an iron-treatment plan. Reticulocyte hemoglobin equivalent (Ret-He) used as marker in most new hematology analyzers to assess incorporation into erythrocyte directly. This study aims examine efficacy...
Studies assessing immune responses following Pfizer-BioNTech BNT162b2 mRNA COVID-19 (Pfizer) and ChAdOx1 nCoV-19 AZD1222 (AstraZeneca) vaccines in patients with hemoglobinopathy are non-existent the literature despite being thought at high risk of infection.Prospectively, we collected serum from hemoglobinopathies least 14 days post vaccine measured neutralizing antibodies (nAb) addition to binding using in-house assays.All 66 participants mounted a significant antibody response (100%), but...
The development of anti-platelet factor 4 (PF4) antibodies is linked to a rare thrombotic complication described now as vaccine-induced immune thrombocytopenia (VITT). This clinical syndrome with thrombosis and was reported after exposure the Oxford-AstraZeneca COVID-19 vaccine, ChAdOx1 nCoV-19 vaccine (AZD1222), Ad26.COV2.S (Janssen/Johnson & Johnson). In absence features, incidence positive anti-PF4 in asymptomatic individuals post-vaccination unclear.The aim this study evaluate 14-21 days...
Background: Sickle cell disease is an inherited blood disorder which can lead to severe complications, particularly in the cardiovascular and respiratory systems, potentially resulting arrhythmias, pulmonary hypertension (PH), cardiomegaly. This study aims investigate risk of PH arrhythmias adult SCD patients. Methods: Retrospective analysis medical records from King Abdulaziz University Hospital (KAUH) for patients with aged 15 above between 2009 2021. The included 517 patients,...
Lymphoma ranks fifth in prevalence among common cancer types worldwide. This lymphatic system arises from T or B cells. Diffuse large cell lymphomas (DLBCLs) are associated with most non-Hodgkin lymphomas. Non-coding microRNAs (miRNAs) greatly affect gene expression. A single miRNA can target numerous genes, thus largely influencing expression networks. MiRNAs act as oncogenes tumor suppressors controlling DLBCL progression. study investigated the roles of miRNAs patients through...
Invasive fungal infections are considered a threat to hematological malignancy patients (HM). We report here rare case of pulmonary aspergillosis in patient diagnosed with leukemia at King Abdulaziz University Hospital. The received three cycles chemotherapy and presented febrile neutropenia his culture was repeatedly negative while signs computed topography (CT) scan were evident. successfully recovered after 6 weeks voriconazole treatment.
β-thalassemia is an inherited blood disorder in which the body cannot produce hemoglobin normally. Since patients with this condition receive transfusions regularly, iron builds up primarily organs such as heart, liver and endocrine glands. Accumulation of necessitates chelation therapy. These must visit hospital frequently to assess follow on their health condition. Physician intervention required after each regular assessment adjust treatment. Lifelong healthcare support using a web-based...
Though patients with sickle cell disease (SCD) are at risk of developing venous thromboembolism (VTE), clear estimates its incidence and predisposing factors in hospitalized SCD not available. Therefore, this issue was addressed to facilitate an early diagnosis initiate appropriate prophylactic treatment strategies. A retrospective observational study conducted on who were admitted academic center Saudi Arabia over a 10-year period. We identified 1054 admissions 394 SCD. Of the 3% VTE, 50%...
The use of tyrosine kinase inhibitors (TKIs) and other targeted therapeutics plays a pivotal role in treatment management for individuals diagnosed with chronic myeloid leukemia (CML). However, some patients may experience fewer favorable outcomes resistance. Our work aims to whole transcriptome sequencing evaluate the variations gene expression patterns among CML based on their response TKI therapy.
BACKGROUND:Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by the presence of Philadelphia (Ph) chromosome, which results from fusion translocation ABL1 gene chromosome 9 to BCR located in 22, forming BCR-ABL on number accounts for approximately 95% CML cases. Complex involving other chromosomes can occur. CASE REPORT:We present rare case with variant Ph 16 was involved usual translocation. A 34-year-old woman presented history left upper quadrant pain and...
Protozoans are endemic in the Middle East and diarrhea workup post stem cell transplant should always include stool examination for ova parasites.
Hemophilia A (HA) is an X-linked recessive disorder that results from mutations in the factor VIII gene (FVIII). Most affected patients are males due to inheritance of FVIII their mothers. Females mostly found be carriers unless they inherited mutation both parents. Obligate HA mothers whose sons with HA, or daughters who inherit fathers. possible carrier could any female has one more relatives her family. (HACs) present similar symptoms patients, including low level, and risk bleeding...
Malignant lymphoma can cause peripheral neuropathy through various mechanisms.We report the case of 67-year-old man with chronic motor and sensory axonal demyelinating polyneuropathy associated anti-ganglioside GQ1b antibodies in serum cerebrospinal fl uid (CSF) as an initial presentation T-cell lymphoma, not otherwise specifi ed.The patient was treated chemotherapy for achieved complete remission.Motor function recovered completely improved.Neurological improvement concurrent disappearance...
Background: The JAK2 V617F mutation’s discovery has largely facilitated the comprehension of myeloproliferative neoplasms’(MPNs) pathogenesis. In recent times, calreticulin (CALR) mutations have been detected in patients with JAK2V617F negative primary myelofibrosis (PMF), and essential thrombocythemia (ET).
 Methods: This study analyzed impact JAK 2 Exon 12 CALR common 65 MPN from Jeddah region. An allele-specific polymerase chain reaction (PCR) method was used to screen four on direct...
Abstract Malignant myeloid sarcoma (chloroma) is a rare extramedullary solid tumor that consists of immature precursor cells, constantly associated with acute leukemia (AML). Here, we report the case 35-year-old male who developed an paraplegia secondary to paraspinal chloroma AML. A careful review patient’s history, blood smear, and bone marrow findings will decrease chance missing diagnosis.
Abstract BACKGROUND: Access of blood donors to banks among several other factors affected rates donation in many during COVID-19. Shortage supply occurred variable degrees countries, including Saudi Arabia. Rather than approaching new donate the time crisis, past constitute a pool potential that may be approached these times. The objective this study was evaluate attitude who donated before pandemic toward donating and identify any specific donor characteristics affect their attitude....
Antiphospholipid antibodies (aPLs) are directed against cell membrane components and can be associated with clinical features or asymptomatic. Testing interpreting these is many challenges pitfalls in practice. To review all antiphospholipid antibody testing describe the practices, indications for interpretation of results to infer local aPL subsequently address ways overcome those challenges. This a retrospective analysis done tertiary center between 2014 2018. Characteristics study...