A5075343899- Venomous Animal Envenomation and Studies
- Drug-Induced Hepatotoxicity and Protection
- Adipokines, Inflammation, and Metabolic Diseases
- Reproductive System and Pregnancy
- Nigella sativa pharmacological applications
- Synthesis and biological activity
- Phytochemicals and Medicinal Plants
- Alcoholism and Thiamine Deficiency
- Biochemical effects in animals
- Pharmacological Effects and Toxicity Studies
- Pharmacology and Nanomedicine Research
- Ion channel regulation and function
- Fatty Acid Research and Health
- Biochemical Acid Research Studies
- Diverse Scientific Research Studies
- Natural Antidiabetic Agents Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Natural Compounds in Disease Treatment
- Folate and B Vitamins Research
- Prenatal Substance Exposure Effects
- Selenium in Biological Systems
- Livestock Management and Performance Improvement
- Enzyme function and inhibition
- GABA and Rice Research
- Leech Biology and Applications
Suez University
2013-2024
Suez Canal University
2016-2022
Rheumatoid arthritis (RA) is a systemic autoimmune disorder characterized by polyarticular symmetrical arthritis. The prevalence of RA consistent worldwide, affecting about 0.5%-1.0% the population. aim this study was to investigate whether Saussurea lappa (costus) could ameliorate adjuvant (AA) in rat for 21 days.Animals were divided into eight groups (n=5/group). Group 1 acted as control, group 2 presented AA rats (positive control), and 3, 4, 5 treated with different doses S. (200, 400,...
Abstract This experiment aimed to investigate the effect of dietary Nigella sativa on cell-mediated immune response. Eighteen male Wistar rats were divided equally into a control group and treated groups that received black seeds at rates 30 50 g/kg in diet (Sa30 Sa50 groups, respectively, for days. The weight gain, feed intake, conversion ratio (FCR), response monitored after injection 0.1 mL 10% phytohemagglutinin (PHA). intumesce index, serum total antioxidant capacity (TAC), catalase...
Varicocele is a leading cause of male infertility. Melatonin highly pleiotropic neurohormone. We aimed to characterize the melatonin epigenetic potential in varicocele and involved molecular mechanisms.Fifty-two albino rats were randomly divided into four groups (13 each): control (I), (II), (III) treated (IV) groups. Left was induced by partial left renal vein ligation. Reproductive hormones, epididymal sperm functional parameters, testicular 3/17 β-hydroxysteroid dehydrogenases,...
Abstract The prevalence of obesity and its associated metabolic disorders, along with their healthcare costs, is rising exponentially. Irisin, an adipomyokine, may serve as a critical cross-organ messenger, linking skeletal muscle adipose tissue the liver to integrate energy homeostasis under diet-induced obesity. We aimed explore putative role irisin in protection against postmenopausal rat model by modulating expenditure (EE). Bilateral ovariectomy (OVX) was performed. After 3 weeks...
Introduction Many foods and phytochemicals are considered to have therapeutic or health-promoting properties. Among these compounds; phytoestrogens received much attention nowadays. They ubiquitous within the plant kingdom they estrogen-like activity.1 a phenolic group
L-Cysteine has protective efficacy in cases of oxidative tissue injury. Sodium valproate is widely used as an anticonvulsant and antidepressant spite hepatotoxicity side effect. The aim this study was to evaluate the role L-cysteine liver toxicity induced by sodium overdose. Release hepatic enzymes, aspartate aminotransferase alanine aminotransferase, levels lipid profiles, well oxidative, enzymatic, non-enzymatic antioxidant were assessed. Liver damage judged histologically. decreased...
The venom apparatus of the scorpion Androctonus amoreuxi has been identified histologically and histochemically in present study. results showed that this composed a pair glands stinger located terminal segment called telson. studied by light microscope SEM. stinger, at end section telson, is sickle-shaped. ejected through pores on its subterminal portion. Both ducts extend along without contact with each other since they are separated connective tissue cells. covered cuticle spines. Each...
This study aimed to examine the protective effect of celastrol on testicular dysfunction in diabetic rats and potential underlying mechanisms. All included were divided into four groups: a control group treated with sodium citrate buffer vehicle), celastrol-treated group, streptozotocin (STZ)-induced following insulin resistance, group. Serum glucose, triglyceride, total cholesterol, high-density lipoprotein interleukin (IL)-1β, tumor necrosis factor-alpha, testosterone levels measured. In...
Background: colorectal cancer is considered to be the third most common cause of deaths in both men and women. The incidence cases has been rising at an alarming rate. In cases, colon treatment involves chemotherapy. However, toxicity tumor cell drug resistance are outstanding obstacles this treatment. Scientific studies suggested that combining certain chemotherapy treatments with specific antioxidants defined dosages can improve efficacy or may reduce side effects severity.5-Fluorouracil,...
In Ayurvedic medicine, the Withania somnifera, known as Ashwagandha, is a common medicinal herb. The purpose of this research was to investigate efficacy Ashwagandha extract an anti-arthritic agent in animal model. Treatment rats with adjuvant-induced arthritis (AIA) extract, well standard drug (Diclofenac Potassium) (10 mg/kg), orally started on day 2 after administration complete Freund's adjuvant and continued until 21st experiment. Animals were divided into ten groups (n=5). Group 1...
Background and Objective: Sodium Valproate (SV) is a medicine that used to treat epilepsy prevent headache.In this study, L-cysteine (LC) was decrease the stress biochemical variations induced by SV treatment.The present study investigated defensive actions of LC vs, testicular impairment.Materials Methods: The rats were split into six groups (n = 10) as following: 1st control animals saline-treated, 2nd 3rd administrated two doses (100 500 mg kgG 1 b.wt.) presenting low high doses,...
Background and Objective: Dimethylnitrosamine (DMN) is a representative chemical of family N-nitroso compounds has been found in processed meats industrial products.Alpha Lipoic Acid (ALA) naturally plants animals involved many different antioxidant functions all body tissues.So, the study was designed to find out efficacy ALA reducing DMN-toxicity male mice by measuring some biomarkers liver as well oxidative stress parameters histopathological changes.Materials Methods: Animals were...
Background: A very high rate of morbidity and mortality is linked to the condition known as rheumatoid arthritis (RA). Objective: The current study has aimed examine impact daily delivery Withania somnifera (W. somnifera) or Ashwagandha extract (ASHE) standard drug (Diclofenac potassium) on oxidative stress inflammatory biomarker in adjuvant-induced (AIA) male albino rats. Materials methods: Animals were divided into ten groups (n=5). Group 1 acted control, group 2 presented RA rats 3, 4, 5...
A total of 78 adult male Albino mice were divided into thirteen groups (6 in each). One served as a control group and the other twelve venom treated groups. The injected with 0.1 ml saline solution which particular amount scorpion venom. first 6 subcutaneously 1/2 LD50 (0.05 microg/g body weight), while 1/4 LD 50 (0.025 weight) by same route. animals from each anesthetized ethyl ether sacrificed at different time intervals (3, 6, 9, 12 hrs, 4 & 7days post toxin administration). microscopic...
A series of 2-(arylidenehydrazono)-5-(2-oxo-2-arylethyl)thiazolidin-4-one derivatives was synthesized, characterized by spectral analyses and evaluated for their in vitro antitumor activity. The IC 50 determination compounds investigated on the human breast cancer cell line MCF-7. Among series, 3, 6, 10, 16, 17, 24 showed remarkable anticancer activity with mean values 2.34, 0.73, 2.69, 3.40, 1.18, 1.76 µg/mL, respectively, against MCF-7 cells. Compound 16 enhanced concentration caspase-9,...
The evaluation of hepatoprotective effect Mustard seed (MS) extract was assessed against paracetamol induced hepatic injury in albino rats. Animals were divided into 4 groups, each 5 Group I served as control group; group II treated with ethanolic from at a dose level 500 mg/kg body weight orally once for 10 days. III represents liver animals using single (PCT). IV combined treatment MS and PCT. Elevated serum marker enzymes such ALT, AST, ALP, GGT LDH observed due to treatment. Combined...
Introduction Cisplatin is a potent well known chemotherapy agent used to treat broad spectrum of malignancies (Sonoda et al., 2019). It was the first FDA-approved platinum compound for cancer treatment in 1978 (Kelland, 2007). has been various cancers including