A5048310014- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Parkinson's Disease Mechanisms and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Drug-Induced Hepatotoxicity and Protection
- Sirtuins and Resveratrol in Medicine
- Selenium in Biological Systems
- Antioxidants, Aging, Portulaca oleracea
- Neuroscience and Neuropharmacology Research
- Ion Channels and Receptors
- Genetics, Aging, and Longevity in Model Organisms
- Menopause: Health Impacts and Treatments
- Advanced Glycation End Products research
- Ion Transport and Channel Regulation
- Caveolin-1 and cellular processes
- Medicinal Plants and Neuroprotection
- Metabolism, Diabetes, and Cancer
- Reproductive Biology and Fertility
- Neonatal Health and Biochemistry
- Paraoxonase enzyme and polymorphisms
- Berberine and alkaloids research
- Lipid metabolism and disorders
- Sphingolipid Metabolism and Signaling
- Medicinal Plants and Bioactive Compounds
Tanta University
2015-2025
Ibn Sina National College for Medical Studies
2024-2025
Czech Academy of Sciences, Institute of Physiology
2023
Zagazig University
2020
Autophagy is necessary for neuronal homeostasis and its dysfunction has been implicated in Parkinson's disease (PD) as it can exacerbate endoplasmic reticulum (ER) stress ER stress-induced apoptosis. Quercetin a flavonoid known neuroprotective antioxidant effects. The present study investigated the protective, autophagy-modulating effects of quercetin rotenone rat model PD. Rotenone was intraperitoneally injected at dose 2 ml/kg/day 4 weeks. Simultaneous intraperitoneal injection given 50...
Doxorubicin (DOX) is an anticancer antibiotic which has various effects in human cancers. It one of the commonly known causes drug-induced nephrotoxicity, results acute renal injury. Adrenomedullin (ADM), a vasodilator peptide, widely distributed many tissues and potent protective effects. Therefore, current study aimed to examine potential mechanisms ADM against DOX-induced nephrotoxicity. A total 28 male Wistar rats were randomized into four groups: control group, doxorubicin group (15...
ABSTRACT Cyclophosphamide (CYP) is an effective chemotherapeutic and immunosuppressive agent; however, its clinical application limited by a variety of toxic side effects. Mitochondrial dysfunction has been associated with the pathogenesis chemotherapy‐induced cardiotoxicity. This work aimed to evaluate possible protective effect galangin (Gal) on CYP‐induced cardiotoxicity, pointing ability promote mitochondrial biogenesis. Thirty two male rats were allocated equally into four groups:...
Varicocele is a leading cause of male infertility. Melatonin highly pleiotropic neurohormone. We aimed to characterize the melatonin epigenetic potential in varicocele and involved molecular mechanisms.Fifty-two albino rats were randomly divided into four groups (13 each): control (I), (II), (III) treated (IV) groups. Left was induced by partial left renal vein ligation. Reproductive hormones, epididymal sperm functional parameters, testicular 3/17 β-hydroxysteroid dehydrogenases,...
Abstract Geraniol (GE), an important ingredient in several essential oils, displayed pleiotropic biological activities through targeting multiple signaling cascades. In the current study, we aimed to examine protective effect of GE on d -galactose ( -gal) induced cognitive impairment and explore underlying mechanisms. Forty male Wistar rats (8 weeks old) were randomly categorized into 4 groups; Group I (saline + vehicle [edible oil]), group II geraniol) (100 mg/kg/day orally), III...
Abstract The prevalence of obesity and its associated metabolic disorders, along with their healthcare costs, is rising exponentially. Irisin, an adipomyokine, may serve as a critical cross-organ messenger, linking skeletal muscle adipose tissue the liver to integrate energy homeostasis under diet-induced obesity. We aimed explore putative role irisin in protection against postmenopausal rat model by modulating expenditure (EE). Bilateral ovariectomy (OVX) was performed. After 3 weeks...
Diabetic nephropathy (DN) is one of the most common microvascular diabetic complications. This study was designed to evaluate possible protective effect and underlying mechanisms HO-1 induction in streptozotocin (STZ)-induced early DN rats. The rats were divided into three groups: STZ-diabetic, cobalt protoporphyrin (CoPP)-treated diabetic, zinc IX (ZnPP)-treated groups. Compared STZ-diabetic group, CoPP-induced upregulation improved state renal functional parameters, suppressed...
Alcoholic liver disease (ALD) encompasses a variety of injuries with various underlying mechanisms but still no effective treatment. So we aimed to monitor the influence simvastatin on alcohol-induced injury and elucidate its cytoprotective effect. Thirty male albino rats were randomly divided into five equal groups. Group 1 (control): received standard diet; group 2: (10 mg kg-1 day -1 ) once orally for 8 weeks; 3: 20% ethanol (7.9 g kg daily 4: along same dose 5: weeks then next weeks....
Parkinson's disease (PD) is the second most common neurodegenerative disease, frequently associated with a gastric ulcer. We aimed to investigate adropin neuroprotective/gastroprotective potential in indomethacin (IND)-induced ulcer rotenone-induced PD model. Rats were randomly divided into four groups: normal control group, rotenone/IND treated (PD /Ulcer) PD/Ulcer and l-dopa/omeprazole (Om) group. There ten rats selected for Striatal dopamine (DA), apoptosis/redox status, motor/behavioral...
ObjectiveTo evaluate the potential apelin effect on hepatic injury in caerulein (Cn) -induced AP rats.
Epilepsy is one of the most widespread neurological disease worldwide. Status epilepticus (SE) a life-threatening neurologic disorder. Neuroprotective approaches are increasingly to discover promising therapy manage epileptic disorders. This study aimed assess impact berberine on some epigenetic, transcription regulation & inflammatory biomarkers in mice model epilepsy.This work was performed on; Group I: (control), II: berberine-treated control,Group III: epilepsy group, IV: epilepsy....
Chronic glucocorticoids therapy is commonly complicated by steroid diabetes, although the underlying mechanisms are still elusive. Liraglutide, a glucagon-like peptide-1, was initially found to induce glycemic control and recently it have many pleotropic effects; however, its role in pancreas remains unknown. The present study aims estimate protective of liraglutide on dexamethasone-induced pancreatic cytotoxicity hyperglycemia, highlighting possible biochemical, molecular, cellular...
Polycystic ovarian syndrome (PCOS) is a multifaceted metabolic and hormonal disorder in females of reproductive age, frequently associated with cardiac disturbances. This research aimed to explore the protective potential adropin and/or tirzepatide (Tirze) on cardiometabolic aberrations letrozole-induced PCOS model. Female Wistar non-pregnant rats were allotted into five groups: CON; PCOS; + adropin; Tirze; adropin+ Tirze. The serum sex hormones, glucose, lipid profiles securitized. Cardiac...
Background: Wound healing is a complex process necessary for repairing damaged tissues and preventing infection. Selenium nanoparticles (Se NPs) were known due to their antioxidant antimicrobial effects, also niacin has angiogenesis effects that are important in wound healing. Objective: The present study was conducted investigate the effect of Se NPs reducing accelerating time mice. Methods: A simple wet chemical method been modified synthesize order on 80 adult female albino mice (250 mm2...
ObjectiveTo evaluate the potential role of sphingosine-1-phosphate receptor agonist, fingolimod (FTY-720), in rat I/R induced testicular injury and its possible underlying protective mechanisms.Experimental protocolThirty male albino rats were categorized into three groups, 10 each: sham operated control group, Ischemia/Reperfusion (I/R) group: underwent torsion/detorsion procedures left testes FTY720 treated (I/R+FTY720) received single injection (at a dose 4 mg/kg i.p) 30 min. before...
IntroductionThe decreased ovarian estrogen production that occurs at menopause, results in osteoporosis and climacteric manifestations, decreases women's quality of life. The hormone replacement therapy (HRT) is the primary treatment options but has been associated with increased oncogenic potential. tissue selective complex (TSEC) a novel therapy, partnering receptor modulator (SERM) one or more estrogens.
Background/Aim: : Nephrotic syndrome (NS) is a potentially life-threatening state characterized by heavy proteinuria, hypoalbuminemia and edema.The underlying pathological mechanisms are diverse have not been fully elucidated.Several molecular processes implicated in its pathophysiology including the Rho-GTPases renin-angiotensin (RAS) systems.We evaluated whether ROCK inhibition , through fasudil RAS interfering Mas agonist, AVE 0991 could renoprotective effect, it comparable to well...
Background: Diabetic nephropathy (DN) is one of the most common and severe microvascular complications diabetes mellitus (DM) leading cause end-stage renal disease.Although hemoxygenase (HO) cytoprotective, potential renoprotective mechanisms HO-1 induction remain to be explored.Aim: The aim this study evaluate possible protective effect HO on streptozotocin (STZ)-induced early DN various underlie in rats.Materials & methods: Single intraperitoneal (i.p.) injection STZ(60mg/kg) was...