A5077754894- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
- Sirtuins and Resveratrol in Medicine
- Adipose Tissue and Metabolism
- Pharmacological Effects of Natural Compounds
- Diet and metabolism studies
- Dialysis and Renal Disease Management
- Asthma and respiratory diseases
- Lipid metabolism and disorders
- Chemotherapy-induced cardiotoxicity and mitigation
- Calcium signaling and nucleotide metabolism
- Biomedical Research and Pathophysiology
- Retinal Diseases and Treatments
- Polyamine Metabolism and Applications
- Viral Infections and Vectors
- Neurogenesis and neuroplasticity mechanisms
- Parasitic Diseases Research and Treatment
- Neonatal Respiratory Health Research
- Amino Acid Enzymes and Metabolism
- Infant Development and Preterm Care
- Environmental Toxicology and Ecotoxicology
- Cancer Treatment and Pharmacology
- Neurological and metabolic disorders
Tanta University
2011-2024
Abstract Background Chronic kidney disease (CKD) signifies a frequently life‐threatening condition influencing structure and function. Despite its irrefutable importance, exact pathogenesis is not completely clarified. However, CKD known to be associated with accumulated uremic toxins/metabolites, interstitial fibrosis, systemic inflammation. So we aimed investigate the role of microbiota‐dependent metabolite trimethylamine N ‐oxide (TMAO), transforming growth factor β (TGFβ)/SMAD signaling,...
Diabetic retinopathy (DR) signifies a frequent serious diabetic complication influencing retinal structure and function. Dysregulation of lncRNAs drives wide array human diseases especially diabetes; thus, we aimed to study lncRNA HIF1A-AS2 role its interplay with hypoxia, oxidative stress (OS), angiogenesis in DR.60 DM patients addition 15 healthy subjects. were enrolled. LncRNA mRNA relative gene expression was assessed. Hypoxia inducible factor 1-alpha (HIF-1α), vascular endothelial...
Ferroptosis is associated with oxidative stress (OS) and caused by iron-dependent lipid-peroxidative damage, but its role in PE unclear. The aim of this study to determine whether pannexin 1 (Panx1) toll-like receptor 4 (TLR4) are key regulators ferroptosis PE.The included 65 patients 25 healthy pregnant women. In normal placental tissues, OS markers, including Fe2+, malondialdehyde (MDA), reduced glutathione (GSH) levels, heme oxygenase-1 (HO-1) peroxidase (Gpx4) activity, were estimated....
Autism spectrum disorder (ASD) is characterized by pervasive impairments in social communication along with repetitive or stereotyped behaviors. Although its distinctive etiology isn`t completely understood, genetic and environmental risk factors were incriminated. Being a flavonoid of high biomedical value, baicalin was recently verified as an emerging medicinal herb numerous pharmacological activities. The objective this study to investigate the feasible effects on valproic acid...
Necroptosis is a tightly adjusted inflammatory necrotizing cell death signaling pathway that participates in pathogenesis of discrete diseases as rheumatoid arthritis (RA). Irisin myokine with immuno-modulatory effect. Evaluation irisin efficiency novel therapeutic agent experimentally induced RA via modulating immuno-inflammatory, necroptotic molecular and biochemical pathways.RA was 30 female Wister albino rats by single subcutaneous injection collagen-II incomplete Freund's adjuvant...
The cardiotoxic effect of chemotherapeutic agents as cisplatin has become a major issue recently. Interference with mitochondrial dynamics, biogenesis, redox status, and apoptosis are the most possible underlying mechanisms. Semaglutide is human glucagon-like peptide-1 receptor agonist (GLP-1R), which used primarily for treatment DM. Various recent studies have investigated (GLP-1R) role in cardiovascular diseases due to antiapoptotic antioxidant effects. current study aimed investigate...
Abstract Multiple sclerosis (MS) is considered to be an autoimmune disorder of the central nervous system (CNS) manifested by chronic inflammation. Although its etiology not completely understood, inflammation and apoptosis are known major players involved in pathogenesis. Luteolin, naturally occurring flavonoid, strong antioxidant anti‐inflammatory properties, yet research studies about therapeutic role MS still lacking. The study aimed provide insight into effects luteolin experimental...
A mechanistic understanding of the dynamic interactions between mitochondria and gut microbiome is thought to offer innovative explanations for many diseases thus provide management approaches, especially in GIT-related autoimmune diseases, such as ulcerative colitis (UC). β-Glucans, important components nutritious diets, including oats mushrooms, have been shown exhibit a variety biological anti-inflammatory immune-modulating actions. Our research study sought insight into function β-glucan...
Necrotizing enterocolitis (NEC) is a frequent serious disease of the digestive system in neonates. It considered as an important cause neonatal complication and death. Therefore, its early suspicion proper management are important.Early sensitive detection NEC through determination levels fecal calprotectin (FCP), serum procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), epithelial neutrophil activating peptide-78 (ENA-78), interleukin 18 (IL-18).This prospective case control...
Introduction. Vigabatrin (VGB) is an antiepileptic drug that acts to irreversibly inhibit the γ-aminobutyric acid (GABA) transaminase enzyme, elevating GABA levels. Broad studies have established long-term treatment and/or high doses of VGB lead variable visual defects. However, little attention has been paid its other side effects, especially those demonstrating cerebellar involvement. Sodium glucose-linked co-transporter 2 (SGLT2) inhibitors are antidiabetic agents with protective effects...
Abstract This study evaluated possible mitigating effect of adropin on lung injury in diabetic rats, targeting role Rho A/Rho‐associated kinase pathway. Rats were allocated into four groups: control, adropin, diabetic, and diabetic+adropin groups. At the termination experiment, serum fasting glucose, insulin levels resistance calculated. Wet/dry ratio, histopathological, immunohistochemical analyses, relative real time gene expression tissue was determined. Interleukin‐6, tumor necrosis...
Cisplatin (CP) is a cornerstone chemotherapeutic agent, however, its neurotoxicity chief cause of limited usage. Linagliptin, which dipeptidyl peptidase-4 enzyme inhibitor, has exhibited considerable neuroprotective potential. We aimed to evaluate the linagliptin modulatory effects on endoplasmic reticulum (ER) stress, redox status, and apoptosis in CP-induced neurotoxicity. Thirty mice were allocated equally into control group, Group II: CP III: treated group. All groups subjected...
Microbiome-Mitochondria interaction is gaining a significant attention; thus, studying its mechanism emerges as must to provide restorative lines in managing diseases. The aim study the mechanistic effects of β-Glucan and/or Celastrol oxazolone-induced ulcerative colitis (UC).75 Wistar rats were allocated into 5 equal groups. Group I: control group. II: UC group, III: β-Glucan-treated IV: Celastrol-treated group & V: mutual treatment All groups subjected detection free fatty acid receptor 2...
Background and aim Crocin is a pharmacologically active chemical found in the spice saffron from Crocus sativus L. It possesses antioxidant anti-radical properties that can minimize hepatic phospholipidosis triggered using tricyclic antidepressant desipramine. The of this study was to examine effect crocin on desipramine-induced targeting oxidative stress-related PI3K/Akt/mTOR signaling pathways.Forty adult male rats were divided into 4 groups (n =10): control group, group receiving...
Abstract Idiopathic Parkinson’s (IP) is a neurodegenerative disease that suspected to be due exposure infections during early life. Toxoplasmosishas been the only parasitic infection in IP (Celik et al., 2010). Recently, some non-central nervous system bacterial and viral have incriminated (Çamcı & Oğuz, 2016). So current study, we tried explore if systemic infl ammatory reactions triggered by helminths like Trichinella spiralis can induce Parkinsonian lesions brain, especially cerebral...
Abstract Normal gonadal function can be disrupted by hypothyroidism. Hypothyroidism disturbs testicular directly and centrally affecting the hypothalamic‐pituitary‐testicular axis with unclear mechanism. As nesfatin‐1 neurons co‐localized TRH GnRH in hypothalamus, it could play a role hypothyroidism induced dysfunction. Selenium (Se), thyroid iodide supply, relieve these disturbances. So, we aim to identify of as link between dysfunction through modulating MAPK/ERK pathway while discussing...
Background: The most prevalent endocrine disorder affecting women is PCOS. Programmed death of ovarian cells has yet to be elucidated. Ferroptosis a kind iron-dependent necrosis featured by significantly Fe+2-dependent lipid peroxidation. ongoing study aimed reinforce fertility combining therapy with AgNPs and (Zileuton) in PCOS rats' model.