A5046394839- Platelet Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer-related molecular mechanisms research
- Ovarian function and disorders
- Advanced Glycation End Products research
- Immunodeficiency and Autoimmune Disorders
- Immune Response and Inflammation
- Flavonoids in Medical Research
- Reproductive Biology and Fertility
- Clusterin in disease pathology
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects of Natural Compounds
- Iron Metabolism and Disorders
- Hepatitis C virus research
- Inflammasome and immune disorders
- Blood groups and transfusion
- Biomarkers in Disease Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Pregnancy and preeclampsia studies
- Neurological Disease Mechanisms and Treatments
- Adipose Tissue and Metabolism
- Angiogenesis and VEGF in Cancer
- Diabetic Foot Ulcer Assessment and Management
- Drug-Induced Ocular Toxicity
Tanta University
2020-2024
Polycystic ovary syndrome (PCOS) has a series of reproductive and metabolic consequences. Although the link between PCOS, IR, obesity, their impact on pathogenesis PCOS yet to be determined. Dysfunction PI3K/AKT pathway been reported as main cause IR in PCOS. This study purposed explore effects selenium nanoparticles (SeNPs) alone combined with metformin (MET) PCOS-IR rat model.After 3 weeks treatment SeNPs and/or MET, biochemical analysis glycemic & lipid profiles, serum hormones was...
Ferroptosis is associated with oxidative stress (OS) and caused by iron-dependent lipid-peroxidative damage, but its role in PE unclear. The aim of this study to determine whether pannexin 1 (Panx1) toll-like receptor 4 (TLR4) are key regulators ferroptosis PE.The included 65 patients 25 healthy pregnant women. In normal placental tissues, OS markers, including Fe2+, malondialdehyde (MDA), reduced glutathione (GSH) levels, heme oxygenase-1 (HO-1) peroxidase (Gpx4) activity, were estimated....
Colorectal cancer is one of the most common cancers worldwide and a major cause cancer-related death. Thus molecular biomarkers for colorectal have been proposed. The role long non-coding RNA EGFR-AS1 in still unclear. We aimed to evaluate its expression different stages determine any possible regulating miR‑133b/EGFR/STAT3 signalling pathway.The relative miR‑133b were evaluated by quantitative real-time RT-transcription PCR 130 samples 30 normal tissues. EGFR was assessed using...
Necroptosis is a tightly adjusted inflammatory necrotizing cell death signaling pathway that participates in pathogenesis of discrete diseases as rheumatoid arthritis (RA). Irisin myokine with immuno-modulatory effect. Evaluation irisin efficiency novel therapeutic agent experimentally induced RA via modulating immuno-inflammatory, necroptotic molecular and biochemical pathways.RA was 30 female Wister albino rats by single subcutaneous injection collagen-II incomplete Freund's adjuvant...
Children with β-thalassemia major (β-TM) suffer from tubular dysfunction even before the onset of any renal impairment symptoms and/or clinical signs. Therefore, identifying innovative biomarkers allowing early damage detection has focused attention.This study aims to preliminary assess Netrin-1(NTN-1) and clusterin (CLU) in β-TM children explore their possible roles as surrogate noninvasive dysfunction.In this study, 40 30 healthy were enrolled. Routine serum urinary biochemical variables...
This study aimed to assess the possible association between two single nucleotide polymorphisms (SNPs) of autoimmune regulator (AIRE) gene (rs2075876 G/A and rs760426 A/G) with risk primary immune thrombocytopenia (ITP), as well AIRE serum levels, in Egyptian population. In this case-control study, 96 cases ITP 100 healthy subjects were included. Two SNPs genotyped via Taqman allele discrimination real-time polymerase chain reaction (PCR). Additionally, levels measured using enzyme-linked...
Abstract Nonsteroidal anti-inflammatory drug (NSAID)-induced kidney injury is one of the most common causes renal failure. The exact pathogenesis NSAID induced not fully known and treatment still challenging. Artemisinin (ART) gains more attention by its potent biological activities in addition to antimalarial effect. In our research, we evaluated preventive therapeutic effects ART Diclofenac (DIC) through effect on mitochondria regulation sirtuin 3 (SIRT3). Thirty adult male Sprague Dawley...
Background: Gastric ulcer is one of the most ubiquitous gastrointestinal tract disorders, causing high morbidity.The goal this study was to explore at mechanistic effects Baicalein (BA) and/or Empagliflozin (EMP) treatment on gastric caused by indomethacin and prednisolone, with an emphasis role HO-1/SIRT1 / HMGB1 signaling pathway.Material methods: Fifty adult albino rats were allocated into 5 equal groups: control, (Prednisolone 10mg/kg for 6 days followed as single oral dose 30 mg/kg), BA...
Background/aim Occult hepatitis C virus infection (OCI) may be present in resolved (HCV) after direct-acting antivirals (DAAs). DAAs improve thrombocytopenia achieving sustained virological response (SVR), but some patients manifested with SVR. The aim of our study was to evaluate the presence OCI peripheral blood mononuclear cells (PBMCs) thrombocytopenic SVR DAAs. Patients and methods This cross-sectional included 32 who achieved HCV-infected without as a control group. All were...