A5033011383- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Transplantation: Methods and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Polyomavirus and related diseases
- Systemic Sclerosis and Related Diseases
- Pulmonary Hypertension Research and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Coronary Interventions and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Medical Imaging and Pathology Studies
- Heart Failure Treatment and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Renal Transplantation Outcomes and Treatments
- Lipoproteins and Cardiovascular Health
- Respiratory viral infections research
- Organ Transplantation Techniques and Outcomes
- Statistics Education and Methodologies
- Cardiac Imaging and Diagnostics
- Occupational and environmental lung diseases
- Health Systems, Economic Evaluations, Quality of Life
- Venous Thromboembolism Diagnosis and Management
- MicroRNA in disease regulation
- Tracheal and airway disorders
- Receptor Mechanisms and Signaling
Duke University
2016-2025
Duke Medical Center
2016-2025
Clinical Research Institute
2016-2025
Duke University Hospital
2013-2025
Canadian Respiratory Research Network
2023
RELX Group (United States)
2020
Weatherford College
2020
Boehringer Ingelheim (Australia)
2020
Roche (United States)
2020
University of Alabama at Birmingham
2014-2017
Background— Adoption of transradial percutaneous coronary intervention (TRI) in the United States is low and may be related to challenges learning technique. We examined relationships between operator TRI volume procedural metrics outcomes. Methods Results— used CathPCI Registry data from July 2009 December 2012 identify new radial operators, defined by an exclusively femoral approach for 6 months after their first database ≥15 total TRIs thereafter. Primary outcomes fluoroscopy time,...
The aim of this study was to determine whether biomarkers myocardial stress and fibrosis improve prediction the mode death in patients with chronic heart failure. 2 most common modes failure are pump sudden cardiac death. Prediction may facilitate treatment decisions. relationship between amino-terminal pro-brain natriuretic peptide (NT-proBNP), galectin-3, ST2, that reflect different pathogenic pathways (myocardial fibrosis), is unknown. HF-ACTION (Heart Failure: A Controlled Trial...
Background— ST2 is involved in cardioprotective signaling the myocardium and has been identified as a potentially promising biomarker heart failure (HF). We evaluated levels their association with functional capacity long-term clinical outcomes cohort of ambulatory patients HF enrolled Heart Failure: A Controlled Trial Investigating Outcomes Exercise Training (HF-ACTION) study—a multicenter, randomized study exercise training HF. Methods Results— HF-ACTION 2331 left ventricular ejection...
Rationale: Lung transplantation is an accepted and increasingly employed treatment for advanced lung diseases, but the anticipated survival benefit of poorly understood.Objectives: To determine whether which patients confers a in modern era U.S. allocation.Methods: Data on 13,040 adults listed between May 2005 September 2011 were obtained from United Network Organ Sharing. A structural nested accelerated failure time model was used to over time. The effects patient, donor, transplant center...
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease for which diagnosis and management remain challenging. Defining the circulating proteome in IPF may identify targets biomarker development. We sought to quantify IPF, determine differential protein expression between subjects with controls, examine relationships markers of severity. Methods This study involved 300 patients from IPF-PRO Registry 100 participants without known disease. Plasma collected at...
Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) play important roles in the turnover extracellular matrix pathogenesis idiopathic pulmonary fibrosis (IPF). This study aimed to determine utility circulating TIMPs distinguishing patients with IPF from controls explore associations between MMPs/TIMPs measures disease severity IPF.The cohort (n = 300) came IPF-PRO Registry, an observational multicenter registry that was diagnosed or confirmed at enrolling center past 6...
The degree to which outcomes following hospitalization for acute heart failure (HF) vary by racial and ethnic groups is poorly characterized. We sought compare 30-day 1-year rehospitalization mortality rates HF among 4 race/ethnic groups.Using the Get With Guidelines-HF registry linked with Medicare data, we compared between racial/ethnic using a multivariable Cox proportional hazards model adjusting clinical, hospital, socioeconomic status characteristics. analyzed 47 149 patients aged ≥65...
Background Cardiovascular clinical trials have traditionally incorporated separate time-to-first-event analyses for their primary efficacy and safety comparisons, but this framework has a number of limitations, including limited patient-centeredness traditional requirement central adjudication. Days alive out the hospital (DAOH) potential to provide additional insight. Methods Results TRILOGY ACS (Targeted Platelet Inhibition Clarify Optimal Strategy Medically Manage Acute Coronary...
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with variable clinical course and high mortality. We used data from large national US registry of patients IPF to investigate relationships between patient characteristics, including markers severity, mortality.The analysis cohort comprised enrolled in the IPF-PRO Registry its inception on 5 June 2014 26 October 2017. The primary criterion for inclusion this that must be diagnosed or confirmed at enrolling centre within 6 months....
Rationale: Acute rejection, manifesting as lymphocytic inflammation in a perivascular (acute rejection [AR]) or peribronchiolar (lymphocytic bronchiolitis [LB]) distribution, is common lung transplant recipients and increases the risk for chronic graft dysfunction.Objectives: To evaluate clinical factors associated with biopsy-proven acute during first post-transplant year present-day, five-center cohort.Methods: We analyzed prospective diagnoses of AR LB from over 2,000 biopsies 400 newly...
There are reported links between periodontal disease (PD) and cardiovascular (CV) risk but data lacking, especially from populations with established coronary heart (CHD). This study describes self-reported indicators of PD associations CV factors in a global stable CHD population.A total 15,828 participants the STABILITY trial underwent physical examination, blood sampling, completed lifestyle questionnaire. They remaining number teeth (none, 1-14, 15-20, 21-25 or 26-32 (all)) frequency gum...
We aimed to study the relationship of chronic kidney disease stages with long-term ischemic and bleeding outcomes in medically managed acute coronary syndrome patients influence more potent antiplatelet therapies on platelet reactivity by stage.We estimated creatinine clearance for 8953 enrolled Targeted Platelet Inhibition Clarify Optimal Strategy Medically Manage Acute Coronary Syndromes trial. Patients were classified stage: normal renal function/mild (creatinine >60 mL/min); moderate...
Rationale: Two antifibrotic medications, nintedanib and pirfenidone, have been approved for the treatment of idiopathic pulmonary fibrosis (IPF) in United States. Few data published on use these medications clinical practice.Objectives: To investigate patterns States.Methods: The Idiopathic Pulmonary Fibrosis Prospective Outcomes (IPF-PRO) Registry, a multicenter U.S. registry, has enrolled patients with IPF that was diagnosed or confirmed at enrolling center past 6 months. Data from June 5,...
Rationale: Lung transplant offers the potential to extend life for patients with idiopathic pulmonary fibrosis (IPF); yet, this therapeutic modality is only available a small proportion of patients. Objectives: To identify clinical characteristics and social determinants health that differentially associate lung compared death in IPF. Methods: We evaluated data from Idiopathic Pulmonary Fibrosis Prospective Outcomes (IPF-PRO) Registry, multicenter U.S. registry IPF was diagnosed or confirmed...
Abstract Background Idiopathic pulmonary fibrosis (IPF) is characterized by the accumulation of extracellular matrix in interstitium and progressive functional decline. We hypothesized that integration multi-omics data would identify clinically meaningful molecular endotypes IPF. Methods The IPF-PRO Registry a prospective registry patients with Proteomic transcriptomic (including total RNA [toRNA] microRNA [miRNA]) analyses were performed using blood collected at enrollment. Molecular...
Abstract Background The circulating metabolome, reflecting underlying cellular processes and disease biology, has not been fully characterized in patients with idiopathic pulmonary fibrosis (IPF). We evaluated whether levels of metabolites correlate the presence IPF, severity or risk clinically relevant outcomes among IPF. Methods analyzed enrollment plasma samples from 300 IPF IPF-PRO Registry 100 individuals without known lung using a set targeted metabolomics clinical analyte modules....
Background Prostasin is expressed in the lung epithelium where it regulates fluid and electrolyte balance via sodium channel proteolysis. We investigated whether circulating prostasin levels are associated with presence severity of IPF levels, or changes them, mortality. Methods Patients came from IPF-PRO Registry. Controls without disease had a similar age/sex distribution. was quantified plasma taken at enrollment and, cohort, approximately 6 months post-enrollment, by immunoassay. Linear...