A5027737351- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Polyomavirus and related diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Mechanical Circulatory Support Devices
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory viral infections research
- Mycobacterium research and diagnosis
- Antifungal resistance and susceptibility
- Cytomegalovirus and herpesvirus research
- Fungal Infections and Studies
- Tracheal and airway disorders
- Organ and Tissue Transplantation Research
- Dysphagia Assessment and Management
- Biomarkers in Disease Mechanisms
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Hepatitis B Virus Studies
- Hepatitis C virus research
- COVID-19 Impact on Reproduction
- Medical Research and Treatments
- Proteoglycans and glycosaminoglycans research
- SARS-CoV-2 and COVID-19 Research
- Family and Patient Care in Intensive Care Units
Duke University
2014-2025
University of Miami
2025
Duke Medical Center
2014-2024
Duke University Hospital
2013-2024
Alfred Health
2024
Trinity College Dublin
2021
St. James's Hospital
2021
Pulmonary and Allergy Associates
2014-2020
Clinical Research Institute
2019
Temple University Hospital
2019
Background: Cytomegalovirus (CMV) is the most prevalent opportunistic infection after lung transplantation. Current strategies do not prevent CMV in at-risk patients. Objective: To determine whether extending prophylaxis with oral valganciclovir from standard 3 months to 12 transplantation efficacious. Design: Randomized, clinical trial. Patients were randomly assigned by a central automated system treatment or placebo. and investigators blinded status. (ClinicalTrials.gov registration...
Rationale: Emerging evidence suggests a restrictive phenotype of chronic lung allograft dysfunction (CLAD) exists; however, the optimal approach to its diagnosis and clinical significance is uncertain.Objectives: To evaluate hypothesis that spirometric indices more suggestive ventilatory defect, such as loss FVC, identify patients with distinct clinical, radiographic, pathologic features, including worse survival.Methods: Retrospective, single-center analysis 566 consecutive first bilateral...
Nontuberculous mycobacteria (NTM) commonly colonize municipal water supplies and cause healthcare-associated outbreaks. We investigated a biphasic outbreak of Mycobacterium abscessus at tertiary care hospital.Case patients had recent hospital exposure laboratory-confirmed colonization or infection with M. from January 2013 through December 2015. conducted multidisciplinary epidemiologic, field, laboratory investigation.The incidence rate increased 0.7 cases per 10000 patient-days during the...
As HLAs antibody detection technology has evolved, there is now detailed HLA information available on prospective transplant recipients. Determining single antigen specificity allows for a calculated panel reactive antibodies (cPRA) value, providing an estimate of the effective donor pool. For broadly sensitized lung candidates (cPRA ≥ 80%), our center adopted pretransplant multi-modal desensitization protocol in effort to decrease cPRA and expand This included plasmapheresis, solumedrol,...
Abstract Background Lung transplant recipients commonly develop invasive fungal infections (IFIs), but the most effective strategies to prevent IFIs following lung transplantation are not known. Methods We prospectively collected clinical data on all patients who underwent at a tertiary care academic hospital from January 2007–October 2014. Standard antifungal prophylaxis consisted of aerosolized amphotericin B lipid complex during hospitalization. For first 180 days after transplant, we...
Rationale: Acute rejection, manifesting as lymphocytic inflammation in a perivascular (acute rejection [AR]) or peribronchiolar (lymphocytic bronchiolitis [LB]) distribution, is common lung transplant recipients and increases the risk for chronic graft dysfunction.Objectives: To evaluate clinical factors associated with biopsy-proven acute during first post-transplant year present-day, five-center cohort.Methods: We analyzed prospective diagnoses of AR LB from over 2,000 biopsies 400 newly...
Abstract Obliterative bronchiolitis (OB) post-lung transplantation involves IL-17–regulated autoimmunity to type V collagen and alloimmunity, which could be enhanced by complement activation. However, the specific role of activation in lung allograft pathology, IL-17 production, OB is unknown. The current study examines OB. Complement-regulatory protein (CRP) (CD55, CD46, receptor 1–related y/CD46) expression was downregulated human murine OB; C3a, a marker activation, upregulated locally....
Primary graft dysfunction (PGD) after lung transplantation may result from ischemia reperfusion injury (IRI). The innate immune response to IRI be mediated by Toll-like receptor and IL-1-induced long pentraxin-3 (PTX3) release. We hypothesized that elevated PTX3 levels were associated with PGD. performed a nested case control study of transplant recipients idiopathic pulmonary fibrosis (IPF) or chronic obstructive disease (COPD) the Lung Transplant Outcomes Group cohort. measured...
Neurocognitive impairments are associated with reduced quality of life and may adversely affect medical compliance, but their prevalence after lung transplantation has not been extensively studied.To examine the frequency neurocognitive impairment to perioperative factors affecting post-transplant function.We performed serial assessments function in a consecutive series 47 subjects who received transplants between March 2013 November (45% women; mean age, 53.5 ± 17.2 yr). was assessed using...
Background. Respiratory syncytial virus (RSV) infection in lung transplant recipients (LTRs) causes mortality rates of 10%–20% despite antiviral therapy. Ribavirin (RBV) has been used to treat RSV-infected LTRs with limited data. Methods. A retrospective study including all at Duke Hospital during January 2013–May 2017 positive RSV polymerase chain reaction respiratory specimens was performed. Results. Fifty-six 70 patients the oral RBV group and 29 32 inhaled had symptomatic infection. One...