A5071562211- Transplantation: Methods and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Organ Transplantation Techniques and Outcomes
- Respiratory viral infections research
- Polyomavirus and related diseases
- Renal Transplantation Outcomes and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral Infections and Immunology Research
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Pulmonary Hypertension Research and Treatments
- RNA Interference and Gene Delivery
- Lymphatic Disorders and Treatments
- Intraperitoneal and Appendiceal Malignancies
- Neurological diseases and metabolism
- Coronary Artery Anomalies
- Intestinal Malrotation and Obstruction Disorders
- Parkinson's Disease Mechanisms and Treatments
- Myasthenia Gravis and Thymoma
- Inflammatory Myopathies and Dermatomyositis
- Extracellular vesicles in disease
- Kawasaki Disease and Coronary Complications
- Neuroblastoma Research and Treatments
- Vascular Malformations and Hemangiomas
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
University of California, Los Angeles
2013-2024
Westwood College
2020
Genetic Analysis (Norway)
2016
Cystic Fibrosis Foundation
2016
Pulmonary and Critical Care Associates
2016
Pulmonary and Allergy Associates
2015
Stanford University
2010
Aspergillus colonization after lung transplantation may increase the risk for bronchiolitis obliterans syndrome (BOS), a disease of small airways. We hypothesized that with conidia species would be associated greater BOS, based upon an increased likelihood deposition in studied adult primary recipients from two large centers; 298 at University California, Los Angeles and 482 Duke Medical Center. grouped by diameter≤3.5 μm. assessed relationship outcomes Cox models. Pre-BOS species, but not...
In Brief Background Community-acquired respiratory virus (CARV) infections occur frequently after lung transplantation and may adversely impact outcomes. We hypothesized that while asymptomatic carriage would not increase the risk of chronic allograft dysfunction (CLAD) graft loss, severe infection would. Methods All transplant cases between January 2000 July 2013 performed at our center were reviewed for viral samples. Each isolation was classified according to clinical level severity:...
The mechanism by which acute allograft rejection leads to chronic remains poorly understood despite its common occurrence. Exosomes, membrane vesicles released from cells within the lung allograft, contain a diverse array of biomolecules that closely reflect biologic state cell and tissue they are released. Exosome transcriptomes may provide better understanding process. Furthermore, biomarkers originating this transcriptome could timely sensitive detection cellular (AR), reducing incidence...
Rationale: Acute rejection, manifesting as lymphocytic inflammation in a perivascular (acute rejection [AR]) or peribronchiolar (lymphocytic bronchiolitis [LB]) distribution, is common lung transplant recipients and increases the risk for chronic graft dysfunction.Objectives: To evaluate clinical factors associated with biopsy-proven acute during first post-transplant year present-day, five-center cohort.Methods: We analyzed prospective diagnoses of AR LB from over 2,000 biopsies 400 newly...
Rationale: The clinical course of chronic lung allograft dysfunction (CLAD) is heterogeneous. Forced vital capacity (FVC) loss at onset, which may suggest a restrictive phenotype, was associated with worse survival for bilateral transplant recipients in one previously published single-center study.Objectives: We sought to replicate the significance FVC an independent, retrospectively identified cohort and investigate extended application this approach single recipients.Methods: other...
Primary graft dysfunction (PGD) is a possible risk factor for bronchiolitis obliterans syndrome (BOS) following lung transplantation; however, the mechanism any such association poorly understood. Based on of TGF-β with acute and chronic inflammatory disorders, we hypothesized that it might play role in continuum between PGD BOS. Thus, BOS was assessed single-center cohort transplant recipients. Bronchoalveolar lavage fluid concentrations procollagen collected within 24 h transplantation...
Background Chronic Lung Allograft Dysfunction (CLAD) is the main limitation to long-term survival after lung transplantation. Although CLAD usually not responsive treatment, earlier identification may improve treatment prospects. Methods In a nested case control study, 1-year post transplant surveillance bronchoalveolar lavage (BAL) fluid samples were obtained from incipient (n = 9) and free 8) recipients. Incipient cases diagnosed with within 2 years, while controls for at least 4 years...
Histopathologic lung allograft injuries are putative harbingers for chronic dysfunction (CLAD). However, the mechanisms responsible not well understood. CXCL9 and CXCL10 potent chemoattractants of mononuclear cells potential propagators injury. We hypothesized that these chemokines would be quantifiable in plasma, associate with subsequent CLAD development. In this prospective multicenter study, we evaluated 721 plasma samples CXCL9/CXCL10 levels from 184 participants at time transbronchial...
Abstract To assess the familial aggregation of Parkinson's disease (PD), we compared cumulative incidence PD among first‐degree relatives cases and controls. We identified newly diagnosed patients with (n = 573) during 1994 to 1995 within Kaiser Permanente Medical Care Program Northern California recruited 496 (87%) for case‐control study. Of 720 eligible controls matched by birth year sex cases, 541 (75%) agreed participate. Information on family history other neurodegenerative diseases was...
We determined prognostic implications of acute lung injury (ALI) and organizing pneumonia (OP), including timing relative to transplantation, in a multicenter recipient cohort. sought understand clinical risks that contribute development ALI/OP. analyzed prospective, histologic diagnoses ALI OP 4786 biopsies from 803 adult recipients. Univariable Cox regression was used evaluate the impact early (≤90 days) or late (>90 posttransplant on risk for chronic allograft dysfunction (CLAD)...
Aspergillus colonization after lung transplant is associated with an increased risk of chronic allograft dysfunction (CLAD). We hypothesized that gene expression during could provide clues to CLAD pathogenesis.We examined transcriptional profiles in 3- or 6-month surveillance bronchoalveolar lavage fluid cell pellets from recipients fumigatus (n = 12) and without 10). Among the colonized, we also explored those who developed 6) remained CLAD-free 6). Transcription were assayed HG-U133 Plus...
Since the initial report in 1963 several small case series described an association between neurofibromatosis (NF) and interstitial lung disease. To date, more than 60 cases of disease associated with NF have been reported, but relatively few reports included high-resolution computed tomographic (HRCT) scans. Typical findings on HRCT include upper lobe predominant cystic bullous disease, ground-glass opacification, basilar reticular abnormalities. We present a 34-year-old male smoker diffuse...
Rationale: Chronic lung allograft dysfunction (CLAD) hinders transplant success. A 2019 consensus refined CLAD diagnosis, introducing probable or definite based on persistence of function decline. Outcomes and risks for remain uncertain. Objectives: We sought to determine the prognosis clinical in a prospective multicenter cohort. Methods: Clinical Trials Organ Transplantation-20 included 745 CLAD-eligible adult recipients at five centers applied rigorous methods prospectively adjudicate...
Background. Chronic lung allograft dysfunction (CLAD) phenotype determines prognosis and may have therapeutic implications. Despite the clarity achieved by recent consensus statement definitions, their reliance on radiologic interpretation introduces subjectivity. The Center for Computer Vision Imaging Biomarkers at University of California, Los Angeles (UCLA) has established protocols chest high-resolution computed tomography (HRCT)-based computer-aided quantification both interstitial...
The long term clinical significance of respiratory infections after lung transplantation remains uncertain.In this retrospective single-center cohort study 441 transplant recipients, we formally evaluate the association between infection and chronic allograft dysfunction (CLAD). We furthermore hypothesized that bronchoalveolar lavage fluid (BALF) CXCL9 concentrations are augmented during infections, episodes with elevated BALF associated greater CLAD risk.In univariable multivariable models...
The association of autoimmune disease (AI) with transplant‐free survival in the setting severe Group 3 pulmonary hypertension and extensive fibrosis remains unclear. We report cases (mean artery pressure ≥35 mmHg right ventricular dysfunction) after arterial hypertension‐specific therapy. used multivariate regression to determine clinical variables associated survival. Of 286 screened patients, 55 demonstrated were treated parenteral prostacyclin (+)AI subgroup (n = 34), when compared (–)AI...
The histopathologic diagnosis of acute allograft injury is prognostically important in lung transplantation with evidence demonstrating a strong and consistent association between rejection (AR), (ALI), the subsequent development chronic dysfunction (CLAD). pathogenesis these injuries, however, remains poorly understood. CXCL9 CXCL10 are CXC chemokines induced by interferon-γ act as potent chemoattractants mononuclear cells. We hypothesized that involved cell recruitment associated AR ALI....
Primary graft dysfunction (PGD) is a complication of lung transplantation that continues to cause significant morbidity. The Th2 immune response has been shown counteract tissue-damaging inflammation. We hypothesized cytokines/chemokines in blood would be associated with protection from PGD. Utilizing pretransplant sera the multicenter clinical trials organ study, we evaluated 211 patients. Increased concentrations cytokines were freedom PGD, namely IL-4 (odds ratio [OR] 0.66 [95% confidence...
Higher-dose mRNA booster vaccines have not been well studied for transplant recipients. This study evaluated the safety, reactogenicity and immunogenicity of higher dose mRNA-1273 among lung recipients (LTRs). phase 1/2 open-label randomized clinical trial higher-dose vaccination enrolled nineteen adult LTRs into 50 ug (n=8) vs. 100 (n=11) groups before enrollment was terminated due to availability bivalent mRNA-1273.222 vaccine. Local systemic predominantly mild or moderate in severity both...
Sweet’s Syndrome (SS), also known as acute febrile neutrophilic dermatosis, is one of several cutaneous inflammatory disorders classified dermatoses. Respiratory complications are described in <50 cases the literature,1Cohen P.R. Sweet's syndrome: a comprehensive review an dermatosis.Orphanet J Rare Dis. 2007; 2: 34Crossref PubMed Scopus (538) Google Scholar without prior report lung transplantation (LT). This article explains clinical course first patient to receive LT for pulmonary SS and...