A5002353467- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Radiomics and Machine Learning in Medical Imaging
- Systemic Sclerosis and Related Diseases
- Pleural and Pulmonary Diseases
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- COVID-19 diagnosis using AI
- Lung Cancer Treatments and Mutations
- Hepatocellular Carcinoma Treatment and Prognosis
- Respiratory Support and Mechanisms
- Advanced Radiotherapy Techniques
- Pulmonary Hypertension Research and Treatments
- Occupational and environmental lung diseases
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- CAR-T cell therapy research
- Transplantation: Methods and Outcomes
- Inflammatory Myopathies and Dermatomyositis
- Sarcoidosis and Beryllium Toxicity Research
- Management of metastatic bone disease
- vaccines and immunoinformatics approaches
- Cancer Genomics and Diagnostics
University of California, Los Angeles
2016-2025
APLA Health
2022
UCLA Health
2016-2021
Ronald Reagan UCLA Medical Center
2009-2021
Centre Léon Bérard
2021
University of Iowa
2020
UCLA Medical Center
2009-2019
UCLA Jonsson Comprehensive Cancer Center
2010
Harvard University Press
2010
Background The recent release of large language models (LLMs) for public use, such as ChatGPT and Google Bard, has opened up a multitude potential benefits well challenges. Purpose To evaluate compare the accuracy consistency responses generated by publicly available ChatGPT-3.5 Bard to non-expert questions related lung cancer prevention, screening, terminology commonly used in radiology reports based on recommendation Lung Imaging Reporting Data System (Lung-RADS) v2022 from American...
Abstract Purpose: A phase I study was conducted to determine safety, clinical efficacy, and antitumor immune responses in patients with advanced non–small cell lung carcinoma (NSCLC) following intratumoral administration of autologous dendritic cells (DC) transduced an adenoviral (Ad) vector expressing the CCL21 gene (Ad-CCL21-DC). We evaluated safety tumor antigen–specific situ vaccination (ClinicalTrials.gov: NCT01574222). Experimental Design: Sixteen stage IIIB/IV NSCLC subjects received...
Coronavirus disease 2019 (COVID-19), is an ongoing issue in certain populations, presenting rapidly worsening pneumonia and persistent symptoms. This study aimed to test the predictability of rapid progression using radiographic scores laboratory markers present longitudinal changes. retrospective included 218 COVID-19 patients admitted at Chungnam National University Hospital. Rapid was defined as respiratory failure requiring mechanical ventilation within one week hospitalization....
Abstract Objective Transforming growth factor β (TGFβ) and platelet‐derived (PDGF) may play a critical role in systemic sclerosis (SSc)–related interstitial lung disease (ILD), imatinib is potent inhibitor of TGFβ PDGF production. In this 1‐year, phase I/IIa open‐label pilot study patients with SSc‐related active ILD, our primary aim was to assess the safety imatinib; we also explored its efficacy. Methods We recruited 20 SSc forced vital capacity (FVC) <85% predicted, dyspnea on...
<h3>Introduction</h3> To assess the feasibility, safety and local tumor control of cryoablation for treatment pulmonary metastases. <h3>Materials Methods</h3> This Health Insurance Portability Accountability Act (HIPAA) compliant, IRB-approved, multicenter, prospective, single arm study included 40 patients with 60 lung metastases treated during 48 sessions, currently a minimum 12 months follow-up. Patients were enrolled according to following key inclusion criteria: 1 5 from extrapulmonary...
Background: The extent of lung involvement visualized by high-resolution computed tomography (HRCT) is a predictor decline in forced vital capacity (FVC) scleroderma-interstitial disease.Our objective was to evaluate the performance three different HRCT-defined staging systems Scleroderma Lung Study I (SLS I) over 1-year period. Methods:We assessed two visual semiquantitative scores: maximum fibrosis score (MaxFib, zone maximal involvement) and assessment total (TLI) as proposed Goh Wells.In...
Abstract Background and objective Endobronchial valve ( EBV ) therapy is optimized in patients who demonstrate little or no collateral ventilation CV ). The accuracy of the C hartis S ystem visual assessment high‐resolution computerized tomography HRCT fissure completeness by a core radiology laboratory for classifying status was compared evaluating relationship each method with target lobe volume reduction TLVR after placement. Methods Retrospective analysis study population underwent...
Consideration of lung transplantation in patients with systemic sclerosis (SSc) remains guarded, often due to the concern for esophageal dysfunction and associated potential allograft injury suboptimal post-lung outcomes.The purpose this study was systematically report our single-center experience regarding setting SSc, a particular focus on dysfunction.We retrospectively reviewed all transplants at center from January 1, 2000 through August 31, 2012 (n = 562), comparing SSc group 35)...
To assess the clinical effectiveness of cryoablation for palliation painful bone metastases.MOTION (Multicenter Study Cryoablation Palliation Painful Bone Metastases) (ClinicalTrials.gov NCT02511678) was a multicenter, prospective, single-arm study adults with metastatic disease who were not candidates or had benefited from standard therapy, that took place February 2016 to March 2018. At baseline, participants rated their pain using Brief Pain Inventory-Short Form (reference range 0 10...
Quantitative CT is becoming increasingly common for the characterisation of lung disease; however, its added potential as a clinical tool predicting severe exacerbations remains understudied. We aimed to develop and validate quantitative CT-based models chronic obstructive pulmonary disease (COPD) exacerbations.
Exercise-induced pulmonary hypertension (ePH) may represent an early, clinically relevant phase in the spectrum of vascular disease. The purpose this pilot study was to describe changes hemodynamics and exercise capacity patients with systemic sclerosis (SSc) spectrum-associated ePH treated open-label daily ambrisentan.Patients were ambrisentan, 5 mg or 10 once daily, for 24 weeks. At baseline weeks, SSc disorders exercised a supine position, on lower extremity cycle ergometer. All had...
<h3>Background</h3> Pulmonary hypertension (PH)-targeted therapy in the setting of pulmonary fibrosis (PF) is controversial; main clinical concern worsening systemic hypoxaemia. We sought to determine effects gentle initiation and chronic administration parenteral treprostinil on right heart function patients with PF associated an advanced PH phenotype. <h3>Methods</h3> Open-label, prospective analysis PF-PH referred for lung transplantation (LT). Advanced was defined as mean artery pressure...
Fibrosis is the end result of most inflammatory conditions, but its pathogenesis remains unclear. We demonstrate that, in animals and humans with systemic fibrosis, plasmacytoid DCs (pDCs) are unaffected or reduced systemically (spleen/peripheral blood), they increase affected organs (lungs/skin/bronchoalveolar lavage). A pivotal role pDCs was shown by depleting them vivo, which ameliorated skin and/or lung immune cell infiltration not spleen, expression genes proteins implicated chemotaxis,...
Chronic obstructive pulmonary disease (COPD) is a common lung disease, and quantitative CT-based bronchial phenotypes are of increasing interest as means exploring COPD sub-phenotypes, establishing progression, evaluating intervention outcomes. Reliable, fully automated, accurate segmentation airway trees critical to such exploration. We present novel approach multi-parametric freeze-and-grow (FG) propagation which starts with conservative parameter captures finer details through iterative...
IntroductionThe ECLIPSE study aimed to evaluate the feasibility and efficacy of cryoablation (CA) for local tumor control in patients with pulmonary metastatic disease 5 years follow-up.MethodsECLIPSE was a prospective, multicenter, single-arm that included treated CA if they had one five lung tumors, each diameter less than or equal 3.5 cm. Patients were followed up course years. The primary end point control, both per patient; secondary points cancer-specific survival, overall quality life...